Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
EN

Melanotan 1

Wróć do opisu substancji

Prace naukowe

BadaniaRodzaj badaniaRok
Afamelanotide for Erythropoietic Protoporphyria.N Engl J MedZ losowaniem grup2015
Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: a randomized multicenter trial.JAMA DermatolZ losowaniem grup2015
Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.Arch DermatolZ losowaniem grup2004
Skin pigmentation and pharmacokinetics of melanotan-I in humans.Biopharm Drug DisposZ losowaniem grup1997
A feasibility and safety study of afamelanotide in acute stroke patients - an open label, proof of concept, phase iia clinical trial.BMC NeurolBez losowania grup2023
Evaluation of the immunogenicity of the synthetic α-melanocyte-stimulating hormone (α-MSH) analogue afamelanotide ([Nle4-D-Phe7]-α-MSH, Scenesse®) in erythropoietic protoporphyria patients by ELISA detecting both anti-afamelanotide and anti-α-MSH antibodies.Skin Pharmacol PhysiolBez losowania grup2015
Efficacy of the melanocortin analogue Nle4-D-Phe7-α-melanocyte-stimulating hormone in the treatment of patients with Hailey-Hailey disease.Clin Exp DermatolBez losowania grup2014
Beneficial effects of the melanocortin analogue Nle4-D-Phe7-α-MSH in acne vulgaris.J Eur Acad Dermatol VenereolBez losowania grup2014
Systemic photoprotection in solar urticaria with α-melanocyte-stimulating hormone analogue [Nle4-D-Phe7]-α-MSH.Br J DermatolBez losowania grup2011
Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of alpha-melanocyte stimulating hormone.Photochem PhotobiolBez losowania grup2009
Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans.Photochem PhotobiolBez losowania grup2000
German Cohort Observational Study to Investigate the Short- and Long-Term Safety and Clinical Effectiveness of Afamelanotide 16 mg (SCENESSE) in Patients With Erythropoietic Protoporphyria (EPP).Photodermatol Photoimmunol PhotomedObserwacja grupy2025
The effects of cholecalciferol and afamelanotide on vitamin D levels in erythropoietic protoporphyria: a multicentre cohort study.Br J DermatolObserwacja grupy2024
Increased phototoxic burn tolerance time and quality of life in patients with erythropoietic protoporphyria treated with afamelanotide - a three years observational study.Orphanet J Rare DisObserwacja grupy2020
A glimpse into the underground market of melanotan.Dermatol Online JObserwacja grupy2018
Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria.Br J DermatolObserwacja grupy2015
Congenital Erythropoietic Porphyria with Persistent Severe Biochemical Abnormalities and a Non-Mutilating Clinical Course: A Case Report.Reports (MDPI)Opisy przypadków2026
From darkness to light: Case report on afamelanotide-treatment in a 9-year-old child with erythropoietic protoporphyria.JAAD Case RepOpisy przypadków2026
Erythropoietic protoporphyria in childhood: clinical clues, missed diagnoses and emerging therapy.Eur J PediatrOpisy przypadków2025
Updates on the diagnosis and management of the most common hereditary porphyrias: AIP and EPP.Hematology Am Soc Hematol Educ ProgramOpisy przypadków2020
The efficacy of afamelanotide and narrowband UV-B phototherapy for repigmentation of vitiligo.JAMA DermatolOpisy przypadków2013
Melanotan II injection resulting in systemic toxicity and rhabdomyolysis.Clin Toxicol (Phila)Opisy przypadków2012
A Review of Randomized Controlled Trials for Vitiligo Therapies Published Between 2013 and 2023.CureusPrzegląd badań2026
New and currently investigated pharmacotherapies for the erythropoietic protoporphyrias: spotlight on dersimelagon and bitopertin.Expert Opin PharmacotherPrzegląd badań2026
Insights into Tanning Biology and Tanning Products.J Clin Aesthet DermatolPrzegląd badań2026
[Hormones and skin pigmentation: fundamentals and clinical relevance].Dermatologie (Heidelb)Przegląd badań2026
Polymorphism of Melanocortin Receptor Genes-Association with Inflammatory Traits and Diseases.DiseasesPrzegląd badań2025
Treatment Advances in Vitiligo: An Updated Review.Dermatol Pract ConceptPrzegląd badań2025
Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management.Liver IntPrzegląd badań2025
Afamelanotide in protoporphyria and other skin diseases: a review.Postepy Dermatol AlergolPrzegląd badań2024
A systematic review of case series and clinical trials investigating systemic oral or injectable therapies for the treatment of vitiligo.Skin Res TechnolPrzegląd badań2024
Bridging Molecular Mechanism and Clinical Practice in Vitiligo Treatment: An Updated Review.DermatologyPrzegląd badań2024
Vitiligo: Pathogenesis and New and Emerging Treatments.Int J Mol SciPrzegląd badań2023
Targeting the central melanocortin system for the treatment of metabolic disorders.Nat Rev EndocrinolPrzegląd badań2023
Etiopathogenesis and Emerging Methods for Treatment of Vitiligo.Int J Mol SciPrzegląd badań2023
Vitiligo, from Pathogenesis to Therapeutic Advances: State of the Art.Int J Mol SciPrzegląd badań2023
Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic review.Biomed PharmacotherPrzegląd badań2023
Immunopathogenesis and management of polymorphic light eruption.Dermatol TherPrzegląd badań2021
Porphyrias in the Age of Targeted Therapies.Diagnostics (Basel)Przegląd badań2021
Afamelanotide: An Orphan Drug with Potential for Broad Dermatologic Applications.J Drugs DermatolPrzegląd badań2021
Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria.Expert Rev Clin PharmacolPrzegląd badań2021
[Melanocortin peptides : Fundamentals, translational research, clinical dermatology, and future perspectives].HautarztPrzegląd badań2020
2019 FDA TIDES (Peptides and Oligonucleotides) Harvest.Pharmaceuticals (Basel)Przegląd badań2020
Emerging drugs for the treatment of vitiligo.Expert Opin Emerg DrugsPrzegląd badań2020
Phototherapy for Vitiligo.Dermatol ClinPrzegląd badań2020
Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management.Mol Genet MetabPrzegląd badań2019
From pathogenesis of acne vulgaris to anti-acne agents.Arch Dermatol ResPrzegląd badań2019
[Porphyrias-what is verified?].Internist (Berl)Przegląd badań2018
An overview of the cutaneous porphyrias.F1000ResPrzegląd badań2017
Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review.Int J DermatolPrzegląd badań2017
The injecting use of image and performance-enhancing drugs (IPED) in the general population: a systematic review.Health Soc Care CommunityPrzegląd badań2017
Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders.Clin PharmacokinetPrzegląd badań2017
Current and emerging treatments for vitiligo.J Am Acad DermatolPrzegląd badań2017
Interventional treatments for Hailey-Hailey disease.J Am Acad DermatolPrzegląd badań2017
Advances in the management of erythropoietic protoporphyria - role of afamelanotide.Appl Clin GenetPrzegląd badań2016
Afamelanotide: A Review in Erythropoietic Protoporphyria.Am J Clin DermatolPrzegląd badań2016
[Erythropoietic protoporphyria : Clinical manifestations, diagnosis and new therapeutic possibilities].HautarztPrzegląd badań2016
[Undesirable pigmentation].HautarztPrzegląd badań2015
Afamelanotide (CUV1647) in dermal phototoxicity of erythropoietic protoporphyria.Expert Rev Clin PharmacolPrzegląd badań2015
Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies.Expert Opin Investig DrugsPrzegląd badań2014
A review and update on melanocyte stimulating hormone therapy: afamelanotide.J Drugs DermatolPrzegląd badań2013
Afamelanotide, an agonistic analog of α-melanocyte-stimulating hormone, in dermal phototoxicity of erythropoietic protoporphyria.Expert Opin Investig DrugsPrzegląd badań2010
Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'?Br J DermatolPrzegląd badań2010
Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.PeptidesPrzegląd badań2006
Discovery and development of novel melanogenic drugs. Melanotan-I and -II.Pharm BiotechnolPrzegląd badań1998
A gel-forming α-MSH analog promotes lasting melanogenesis.Eur J PharmacolNa zwierzętach2023
Effects of the central melanocortin system on feed intake, metabolic hormones and insulin action in the sheep.J Anim SciNa zwierzętach2023
Pharmacologic response of a controlled-release PLGA formulation for the alpha-melanocyte stimulating hormone analog, Melanotan-I.Pharm ResNa zwierzętach2000
Controlled-release delivery system for the alpha-MSH analog melanotan-I using poloxamer 407.J Pharm SciNa zwierzętach1996
Acute impact of afamelanotide on UVR erythemal and melanogenic responses in healthy humans in vivo: an exploratory study.Photochem Photobiol SciInna praca2026
Heterochiral co-assembly of β-strands and hairpins affords stereocomplexed peptide hydrogels for drug delivery.J Control ReleaseInna praca2026
Investigation of the stability profile of therapeutic α-MSH analogue: Insights from liquid chromatography-high resolution mass spectrometry analysis of afamelanotide.J Pharm Biomed AnalInna praca2026
Afamelanotide improves quality of life and light tolerance in Austrian erythropoietic protoporphyria patients.J Dtsch Dermatol GesInna praca2026
New pharmacotherapies for the erythropoietic protoporphyrias: an analysis of trial protocols from a patient perspective.Orphanet J Rare DisInna praca2025
Burden of illness and unmet needs in patients with erythropoietic protoporphyria and X-linked protoporphyria: A large US nationwide claims analysis.J Manag Care Spec PharmInna praca2025
Afamelanotide in managing cutaneous phototoxicity in erythropoietic protoporphyria: a Scottish perspective.Clin Exp DermatolInna praca2025
Silica-Assisted Solid-Phase Peptide Synthesis (SiPPS).J Pept SciInna praca2025
A single-centre, prospective, qualitative analysis of knowledge, attitudes and behaviour of sunbed use among patients attending a pigmented lesion clinic in a tertiary referral centre.Skin Health DisInna praca2025
The Impact of Minimal Sunlight Exposure on Bone Health: Insights From a Cohort Study in Erythropoietic Protoporphyria.J Clin Endocrinol MetabInna praca2025
Discovery of MT-7117 (Dersimelagon Phosphoric Acid): A Novel, Potent, Selective, and Nonpeptidic Orally Available Melanocortin 1 Receptor Agonist.J Med ChemInna praca2024
Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for In Vitro Release Testing: Development and Validation.ACS Appl Bio MaterInna praca2024
Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).ACS Pharmacol Transl SciInna praca2024
When the diagnosis is written in the DNA: a case of erythropoietic protoporphyria in a patient with a chromosome-18 deletion.Dermatol ReportsInna praca2024
Afamelanotide for Treatment of the Protoporphyrias: Impact on Quality of Life and Laboratory Parameters in a US Cohort.Life (Basel)Inna praca2024
Fair Funding Decisions: Consistency of the Time Horizons Used in the Calculation of Quality-Adjusted Life Years for Therapies for Very Rare Diseases by the National Institute for Health and Care Excellence in England.Int J Environ Res Public HealthInna praca2024
Erythropoietic protoporphyria and afamelanotide: a patient's perspective.Clin Exp DermatolInna praca2024
Into the Light: Afamelanotide and the Treatment of Erythropoietic Protoporphyria in the United States.J Drugs DermatolInna praca2023
Afamelanotide Is Associated with Dose-Dependent Protective Effect from Liver Damage Related to Erythropoietic Protoporphyria.Life (Basel)Inna praca2023
Erythropoietic protoporphyria in the Netherlands: Clinical features, psychosocial impact and the effect of afamelanotide.J DermatolInna praca2023
Association of quality of life measures with afamelanotide treatment in patients with erythropoietic protoporphyria and x-linked protoporphyria: A retrospective cohort study.J Am Acad DermatolInna praca2023
Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance Gene mecA in Methicillin-Resistant Staphylococcus aureus (MRSA) Strains.BioTech (Basel)Inna praca2023
Quality-Adjusted Life Years in Erythropoietic Protoporphyria and Other Rare Diseases: A Patient-Initiated EQ-5D Feasibility Study.Int J Environ Res Public HealthInna praca2023
Implementation of a high-impact medication therapy subcommittee within a large academic medical center.Am J Health Syst PharmInna praca2023
Discovery of novel N-(1-benzyl-1H-imidazol-2-yl)amide derivatives as melanocortin 1 receptor agonists.Bioorg Med Chem LettInna praca2022
Objective light exposure measurements and circadian rhythm in patients with erythropoietic protoporphyria: A case-control study.Mol Genet MetabInna praca2022
Beyond pigmentation: signs of liver protection during afamelanotide treatment in Swiss patients with erythropoietic protoporphyria, an observational study.Ther Adv Rare DisInna praca2021
Structural insights into ligand recognition and activation of the melanocortin-4 receptor.Cell ResInna praca2021
Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor.Cell ResInna praca2021
Erythropoietic protoporphyria: time to prodrome, the warning signal to exit sun exposure without pain-a patient-reported outcome efficacy measure.Genet MedInna praca2021
Clinical and dermoscopic changes of acquired melanocytic nevi of patients treated with afamelanotide.Photochem Photobiol SciInna praca2021
Association of Afamelanotide With Improved Outcomes in Patients With Erythropoietic Protoporphyria in Clinical Practice.JAMA DermatolInna praca2020
[Medicaments and oral healthcare. Hyperpigmentation of oral soft tissues due to afamelanotide].Ned Tijdschr TandheelkdInna praca2020
Afamelanotide in the Treatment of Dermatologic Disease.Skin Therapy LettInna praca2018
Current challenges in photoprotection.J Am Acad DermatolInna praca2017
Photoprotection: part I. Photoprotection by naturally occurring, physical, and systemic agents.J Am Acad DermatolInna praca2013
A bioassay for the detection of neutralizing antibodies against the α-melanocyte stimulating hormone analog afamelanotide in patients with erythropoietic protoporphyria.J Pharm Biomed AnalInna praca2013
Patient-recorded outcome to assess therapeutic efficacy in protoporphyria-induced dermal phototoxicity: a proposal.Health Qual Life OutcomesInna praca2010
Nonsurgical innovations in the treatment of nonmelanoma skin cancer.J Clin Aesthet DermatolInna praca2010
Gateways to clinical trials.Methods Find Exp Clin PharmacolInna praca2009
Gateways to clinical trials.Methods Find Exp Clin PharmacolInna praca2007
High-performance liquid chromatographic assay for Melanotan-1 ([Nle4-DPhe7]alpha-melanocyte-stimulating hormone) in biological matrices.J Chromatogr B Biomed ApplInna praca1995

Te prace znaleźliśmy automatycznie w bazie PubMed. Redakcja jeszcze ich nie przeczytała i nie wpływają na żadną ocenę. Tytuły są w oryginale. W każdej grupie pokazujemy najnowsze prace do ustalonego limitu. Pełną listę ma PubMed.

Otwórz w PubMed

Zarejestrowane badania na ludziach (24)

BadaniaEtapStatusLiczba uczestnikówAktualizacja
Pharmacokinetics of Afamelanotide in Erythropoietic Protoporphyria PatientsEtap 1, Etap 2Zakończone282026-07-27
Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental VitiligoEtap 2Szuka uczestników602026-02-27
A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With VitiligoEtap 3Trwa, bez nowych osób2002025-07-08
Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Variegate Porphyria (VP)Etap 2Zakończone62025-04-27
Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Phototherapy in the Treatment of Nonsegmental Vitiligo (NSV)Etap 2Zakończone212023-09-22
A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and VEtap 2Nieznany62023-09-21
A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP)Etap 2Nieznany62023-06-18
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)Etap 2Zakończone62023-04-11
A Study to Assess the Changes in Pigmentation and Safety of Afamelanotide in Patients With Vitiligo on the FaceEtap 2Nieznany62023-02-09
DNA Repair Capacity of Afamelanotide on Ultraviolet Radiation-induced DNA Damage in Healthy VolunteersEtap 1Zakończone102023-02-09
Afamelanotide in Patients Suffering With Acne VulgarisEtap 2Zakończone32021-10-26
Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP)Etap 3Zakończone742021-10-12
Afamelanotide as Adjunctive Therapy in Patients Undergoing Photodynamic Therapy (PDT) Utilising Porfimer SodiumEtap 2Zakończone162021-10-01
Afamelanotide in Patients Suffering From Polymorphic Light Eruption (PLE)Etap 3Zakończone312021-03-19
A Safety Extension Study in Patients With Erythropoietic Protoporphyria (EPP)Etap 3Zakończone162020-11-19
Phase II Confirmatory Study in Erythropoietic Protoporphyria (EPP)Etap 2Zakończone772019-10-28
Multicentre Phase III Erythropoietic Protoporphyria StudyEtap 3Zakończone1002019-10-10
Phase III Confirmatory Study in Erythropoietic ProtoporphyriaEtap 3Zakończone932019-09-19
Implant Pharmacokinetic and Pharmacodynamic StudyEtap 1Zakończone242018-08-16
Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental VitiligoEtap 2Zakończone152013-03-22
Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo (NSV)Etap 1Zakończone562013-03-22
Phase III Trial of CUV1647 in Polymorphic Light Eruption (PLE)–Zakończone182011-10-05
Phase II AK Study in Organ Transplant PatientsEtap 2Nieznany2002010-12-06
Phase II Solar Urticaria (SU) Pilot StudyEtap 2Zakończone52009-09-15