Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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Tymozyna alfa-1

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Efficacy and safety of thymosin α1 combined with chemotherapy for gastric cancer: a systematic review and meta-analysis of randomized controlled trials.Front ImmunolAnaliza zbiorcza2026
Thymosin-ɑ1 for people with chronic hepatitis B.Cochrane Database Syst RevAnaliza zbiorcza2026
Efficacy of thymosin α1 for sepsis: a systematic review and meta-analysis of randomized controlled trials.Front Cell Infect MicrobiolAnaliza zbiorcza2025
Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis.Front ImmunolAnaliza zbiorcza2025
The Effect of Ulinastatin on Sepsis Outcomes: An Umbrella Review of Meta-Analysis.Clin TherAnaliza zbiorcza2025
Thymosin Alpha 1 Plus Routine Treatment for the Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.J Coll Physicians Surg PakAnaliza zbiorcza2024
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression.InflammopharmacologyAnaliza zbiorcza2023
Thymosin alpha1 use in adult COVID-19 patients: A systematic review and meta-analysis on clinical outcomes.Int ImmunopharmacolAnaliza zbiorcza2023
The clinical efficacy and adverse effects of Entecavir plus Thymosin alpha-1 combination therapy versus Entecavir Monotherapy in HBV-related cirrhosis: a systematic review and meta-analysis.BMC GastroenterolAnaliza zbiorcza2020
Clinical efficacy and safety of synthetic thymic peptides with chemotherapy for non-small cell lung cancer in China: A systematic review and meta-analysis of 27 randomized controlled trials following the PRISMA guidelines.Int ImmunopharmacolAnaliza zbiorcza2019
Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted.Cochrane Database Syst RevAnaliza zbiorcza2019
Effect of ulinastatin combined with thymosin alpha1 on sepsis: A systematic review and meta-analysis of Chinese and Indian patients.J Crit CareAnaliza zbiorcza2017
The efficacy of thymosin α1 as immunomodulatory treatment for sepsis: a systematic review of randomized controlled trials.BMC Infect DisAnaliza zbiorcza2016
Ulinastatin and/or thymosin α1 for severe sepsis: A systematic review and meta-analysis.J Trauma Acute Care SurgAnaliza zbiorcza2016
The Efficacy and Immunomodulatory Effects of Ulinastatin and Thymosin α1 for Sepsis: A Systematic Review and Meta-Analysis.Biomed Res IntAnaliza zbiorcza2016
Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.Int ImmunopharmacolAnaliza zbiorcza2015
Thymosin alpha1 based immunomodulatory therapy for sepsis: a systematic review and meta-analysis.Int J Infect DisAnaliza zbiorcza2015
Phyllanthus species versus antiviral drugs for chronic hepatitis B virus infection.Cochrane Database Syst RevAnaliza zbiorcza2013
Thymic peptides for treatment of cancer patients.Cochrane Database Syst RevAnaliza zbiorcza2011
[Treatment with interferon and thymosin alpha-1 versus interferon monotherapy for HBeAg positive chronic hepatitis B: a meta-analysis].Zhonghua Gan Zang Bing Za ZhiAnaliza zbiorcza2011
Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted.Cochrane Database Syst RevAnaliza zbiorcza2010
[Evaluation of efficacy of thymosin alpha1 in the treatment of sepsis: a systematic review].Zhongguo Wei Zhong Bing Ji Jiu Yi XueAnaliza zbiorcza2009
Comparison of the efficacy of thymosin alpha-1 and interferon alpha in the treatment of chronic hepatitis B: a meta-analysis.Antiviral ResAnaliza zbiorcza2008
Preliminary results from a phase II trial of spatially fractionated radiotherapy combined with immunotherapy and anti-angiogenic therapy in patients with bulky solid tumors: early evidence of promising efficacy and favorable safety.Radiat OncolZ losowaniem grup2026
Thymosin α1 improves the outcomes of patients with hepatitis B virus-related acute-on-chronic liver failure by restoring immune balance.Immunopharmacol ImmunotoxicolZ losowaniem grup2026
The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial.BMJZ losowaniem grup2025
A Prospective and Randomized Control Study on Effects of Thymalfasin for Injection on Perioperative Immune Function and Long-term Prognosis of Patients with Colorectal Cancer.Biotechnol Genet Eng RevZ losowaniem grup2024
Immune-Enhancing Treatment among Acute Necrotizing Pancreatitis Patients with Metabolic Abnormalities: A Post Hoc Analysis of a Randomized Clinical Trial.Gut LiverZ losowaniem grup2024
A pilot trial of Thymalfasin (Ta1) to prevent covid-19 infection and morbidities in renal dialysis patients: Preliminary report.Int ImmunopharmacolZ losowaniem grup2023
Value of Thymosin α1 Combined With Blood Purification to Increase Successful Rescues of Shock Patients.Altern Ther Health MedZ losowaniem grup2022
Safety and efficacy of Thymosin α1 in the treatment of hepatitis B virus-related acute-on-chronic liver failure: a randomized controlled trial.Hepatol IntZ losowaniem grup2022
Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial.Intensive Care MedZ losowaniem grup2022
The effect of thymopentin add-on in hepatitis B e antigen positive chronic hepatitis B after virus suppression by peginterferon plus entecavir therapy.Cell Mol Biol (Noisy-le-grand)Z losowaniem grup2019
Combination of entecavir with thymosin alpha-1 in HBV-related compensated cirrhosis: a prospective multicenter randomized open-label study.Expert Opin Biol TherZ losowaniem grup2018
[Prevention Effect of Thymosin-alpha1 Aganist Early Ventilator-associated Pneumonia in Patients with Mechanical Ventilation].Sichuan Da Xue Xue Bao Yi Xue BanZ losowaniem grup2015
[Effect of Acupuncture on Prognosis and Immune Function of Sepsis Patients].Zhongguo Zhong Xi Yi Jie He Za ZhiZ losowaniem grup2015
Thymosin α1 plus routine treatment inhibit inflammatory reaction and improve the quality of life in AECOPD patients.Immunopharmacol ImmunotoxicolZ losowaniem grup2015
A multicenter, randomized, observation-controlled clinical trial to evaluate the efficacy and safety of thymalfasin adjuvant therapy in patients with HBV-related HCC after curative resection - first announcement of the protocol.Expert Opin Biol TherZ losowaniem grup2015
The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial.Crit CareZ losowaniem grup2013
Efficacy of thymosin α-1 plus peginterferon α-2a combination therapy compared with peginterferon α-2a monotherapy in HBeAg-positive chronic hepatitis B: a prospective, multicenter, randomized, open-label study.Scand J GastroenterolZ losowaniem grup2012
Thymosin alpha-1 with peginterferon alfa-2a/ribavirin for chronic hepatitis C not responsive to IFN/ribavirin: an adjuvant role?J Viral HepatZ losowaniem grup2012
Thymosin alpha 1 is associated with improved cellular immunity and reduced infection rate in severe acute pancreatitis patients in a double-blind randomized control study.InflammationZ losowaniem grup2011
Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma.J Clin OncolZ losowaniem grup2010
Effect of thymosin-α(1) on T-helper 1 cell and T-helper 2 cell cytokine synthesis in patients with hepatitis B virus e antigen-positive chronic hepatitis B.J Int Med ResZ losowaniem grup2010
[Immune and inflammation confusion in severe sepsis and effects of bi-immunomodulation therapy: a prospective, randomized, controlled clinical trial].Zhonghua Yi Xue Za ZhiZ losowaniem grup2009
Treatment of patients with severe sepsis using ulinastatin and thymosin alpha1: a prospective, randomized, controlled pilot study.Chin Med J (Engl)Z losowaniem grup2009
[Clinical effects of ulinastatin and thymosin alpha1 on immune-modulation in septic patients].Zhongguo Wei Zhong Bing Ji Jiu Yi XueZ losowaniem grup2009
[Effect of continuous blood purification and thymosin alpha1 on the cellular immunity in patients with severe sepsis: a prospective, randomized, controlled clinical trial].Zhongguo Wei Zhong Bing Ji Jiu Yi XueZ losowaniem grup2009
A new immunomodulatory therapy for severe sepsis: Ulinastatin Plus Thymosin {alpha} 1.J Intensive Care MedZ losowaniem grup2009
Thymosin alpha1- and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria.J Infect DisZ losowaniem grup2008
[The prophylactic effect of thymosin alpha 1 on the acute exacerbation of chronic obstructive pulmonary disease].Sichuan Da Xue Xue Bao Yi Xue BanZ losowaniem grup2008
Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study.Am J Emerg MedZ losowaniem grup2008
Combination therapy of thymosin alpha-1 and lamivudine for HBeAg positive chronic hepatitis B: A prospective randomized, comparative pilot study.J Gastroenterol HepatolZ losowaniem grup2008
Thymosin alpha 1 as an adjunct to influenza vaccination in the elderly: rationale and trial summaries.Ann N Y Acad SciZ losowaniem grup2007
[Effects of thymosin-alpha1 on cell immunity function in patients with septic shock].Zhongguo Wei Zhong Bing Ji Jiu Yi XueZ losowaniem grup2007
[Clinical trial with a new immunomodulatory strategy: treatment of severe sepsis with Ulinastatin and Maipuxin].Zhonghua Yi Xue Za ZhiZ losowaniem grup2007
Hepatitis B virus genotype B is associated with better response to thymosin alpha1 therapy than genotype C.J Viral HepatZ losowaniem grup2006
Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B: a randomized controlled study.World J GastroenterolZ losowaniem grup2006
[Clinical study and long-term evaluation of immunomodulation therapy on trauma, severe sepsis and multiple organ dysfunction syndrome patients].Zhongguo Wei Zhong Bing Ji Jiu Yi XueZ losowaniem grup2006
A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B.Antivir TherZ losowaniem grup2006
[Prevention and management of lung infections with thymosin alpha1 in critical patients with tracheotomy].Nan Fang Yi Ke Da Xue Xue BaoZ losowaniem grup2006
[Antiviral therapy of chronic hepatitis B patients resistant to lamivudine].Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za ZhiZ losowaniem grup2005
The efficacy and safety of thymosin alpha-1 in Japanese patients with chronic hepatitis B; results from a randomized clinical trial.J Viral HepatZ losowaniem grup2005
[Anti-viral therapy using lamivudine and thymosin is helpful to prevent recurrence in hepatocellular carcinoma with coexisting active hepatitis B].Zhonghua Zhong Liu Za ZhiZ losowaniem grup2005
A randomized, controlled, clinical study of thymosin alpha-1 versus interferon-alpha in [corrected] patients with chronic hepatitis B lacking HBeAg in China [corrected].J Chin Med AssocZ losowaniem grup2005
Combination therapy of thymalfasin (thymosin-alpha 1) and peginterferon alfa-2a in patients with chronic hepatitis C virus infection who are non-responders to standard treatment.J Gastroenterol HepatolZ losowaniem grup2004
Combination transcatheter hepatic arterial chemoembolization with thymosin alpha1 on recurrence prevention of hepatocellular carcinoma.HepatogastroenterologyZ losowaniem grup2004
[Transcatheter hepatic arterial chemoembolization and thymosin alpha1 in postoperative treatment of hepatocellular carcinoma].Zhonghua Zhong Liu Za ZhiZ losowaniem grup2004
Thymalfasin for the treatment of chronic hepatitis B.Expert Rev Anti Infect TherZ losowaniem grup2004
Thymosin-alpha 1 plus interferon-alpha for naive patients with chronic hepatitis C: results of a randomized controlled pilot trial.J Viral HepatZ losowaniem grup2004
A pilot study of the safety and efficacy of thymosin alpha 1 in augmenting immune reconstitution in HIV-infected patients with low CD4 counts taking highly active antiretroviral therapy.Clin Exp ImmunolZ losowaniem grup2003
A pilot study of thymosin alpha1 therapy for chronic hepatitis B patients.Intern MedZ losowaniem grup2003
A randomized, controlled study of thymosin-alpha1 therapy in patients with anti-HBe, HBV-DNA-positive chronic hepatitis B.Dig Dis SciZ losowaniem grup2000
Thymosin alpha1 treatment of chronic hepatitis B: results of a phase III multicentre, randomized, double-blind and placebo-controlled study.J Viral HepatZ losowaniem grup1999
Pharmacokinetics of thymosin alpha1 after subcutaneous injection of three different formulations in healthy volunteers.Int J Clin Pharmacol TherZ losowaniem grup1999
Interferon and thymosin combination therapy in naive patients with chronic hepatitis C: preliminary results.LiverZ losowaniem grup1998
Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial.HepatologyZ losowaniem grup1998
Combination therapy with thymosin alpha1 and interferon for the treatment of chronic hepatitis C infection: a randomized, placebo-controlled double-blind trial.HepatologyZ losowaniem grup1998
A randomized controlled trial of thymosin-alpha1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody--and hepatitis B virus DNA--positive chronic hepatitis B.HepatologyZ losowaniem grup1996
A pilot study of thymosin-alpha 1 therapy for chronic hepatitis D.J Clin GastroenterolZ losowaniem grup1996
A double-blind, placebo-controlled, pilot trial of thymosin alpha 1 for the treatment of chronic hepatitis C.LiverZ losowaniem grup1996
Combined treatment with thymosin-alpha1 and low-dose interferon-alpha after ifosfamide in non-small cell lung cancer: a phase-II controlled trial.Anticancer ResZ losowaniem grup1996
Combination treatment with zidovudine, thymosin alpha 1 and interferon-alpha in human immunodeficiency virus infection.Int J Clin Lab ResZ losowaniem grup1994
Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial.HepatologyZ losowaniem grup1991
Augmentation of influenza antibody response in elderly men by thymosin alpha one. A double-blind placebo-controlled clinical study.J Am Geriatr SocZ losowaniem grup1989
A randomized trial to evaluate the immunorestorative properties of synthetic thymosin-alpha 1 in patients with lung cancer.J Biol Response ModZ losowaniem grup1985
T-cell abnormalities after mediastinal irradiation for lung cancer. The in vitro influence of synthetic thymosin alpha-1.CancerZ losowaniem grup1985
Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial.BMC MedBez losowania grup2026
Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter Phase II clinical trial.Cancer Immunol ImmunotherBez losowania grup2025
Efficacy of Thymosin α1 in Management of Radiation Pneumonitis in Patients With Locally Advanced Non-Small Cell Lung Cancer Treated With Concurrent Chemoradiotherapy: A Phase 2 Clinical Trial (GASTO-1043).Int J Radiat Oncol Biol PhysBez losowania grup2022
Hypofractionated Radiation Therapy Combined With Weekly Chemotherapy in Patients With Unresectable or Recurrent Thymic Epithelial Tumor: A Prospective, Single-Arm Phase 2 Study (GASTO-1042).Int J Radiat Oncol Biol PhysBez losowania grup2022
The Effect of Recombinant Human Interferon Alpha Nasal Drops to Prevent COVID-19 Pneumonia for Medical Staff in an Epidemic Area.Curr Top Med ChemBez losowania grup2021
[Effect of transcatheter arterial chemoembolization combined with thymosin alpha 1 on the autophagy of immune cells from advanced hepatocellular carcinoma].Zhonghua Yi Xue Za ZhiBez losowania grup2017
Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection.PLoS OneBez losowania grup2016
Efficacy of triple therapy with thymalfasin, peginterferon alpha-2a, and ribavirin for the treatment of hispanic chronic HCV nonresponders.Ann HepatolBez losowania grup2008
[Combination therapy of thymosin alpha1 and high dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura].Zhonghua Nei Ke Za ZhiBez losowania grup2007
[A clinical study of thymosin alpha1 as an auxiliary in treating spontaneous peritonitis in patients with liver cirrhosis].Zhonghua Gan Zang Bing Za ZhiBez losowania grup2007
Antiviral therapy using lamivudine and thymosin alpha1 for hepatocellular carcinoma coexisting with chronic hepatitis B infection.HepatogastroenterologyBez losowania grup2006
Combination therapy of thymalfasin (thymosin-alpha 1) and peginterferon alfa-2a in patients with chronic hepatitis C virus infection who are non-responders to standard treatment.J Gastroenterol HepatolBez losowania grup2004
Triple combination of thymalfasin, peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior interferon and ribavirin treatment: 24-week interim results of a pilot study.J Gastroenterol HepatolBez losowania grup2004
[Clinical trial of sequential antiviral therapy for patients with chronic hepatitis B in China].Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za ZhiBez losowania grup2004
Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B.J Pharm SciBez losowania grup2003
Thymosin-alpha1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phase.J Viral HepatBez losowania grup2002
Thymosin alpha in the treatment of chronic hepatitis B: an uncontrolled open-label trial.Indian J GastroenterolBez losowania grup2002
The combined treatment of interferon alpha-2a and thymosin alpha 1 for chronic hepatitis C: the 48 weeks end of treatment results.J Med Assoc ThaiBez losowania grup2001
Combined treatment with thymosin-alpha1 and low dose interferon-alpha after dacarbazine in advanced melanoma.Melanoma ResBez losowania grup2000
Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin alpha1 and thymulin concentrations: observations in rats and humans.J NeuroimmunolBez losowania grup2000
Combination low-dose lymphoblastoid interferon and thymosin alpha 1 therapy in the treatment of chronic hepatitis B.J Viral HepatBez losowania grup1996
Polyethylene glycol-modified interleukin-2 and thymosin alpha 1 in human immunodeficiency virus type 1 infection.J Infect DisBez losowania grup1996
Sequential chemoimmunotherapy for advanced non-small cell lung cancer using cisplatin, etoposide, thymosin-alpha 1 and interferon-alpha 2a.Eur J CancerBez losowania grup1995
Treatment with thymosin alpha-1 increases fertilizing capacity of sperm of infertile men: a multicenter trial.Arch AndrolBez losowania grup1995
Biochemotherapy with thymosin alpha 1, interleukin-2 and dacarbazine in patients with metastatic melanoma: clinical and immunological effects.Ann OncolBez losowania grup1994
Thymosin in the early diagnosis and treatment of high risk homosexuals and hemophiliacs with AIDS-like immune dysfunction.Ann N Y Acad SciBez losowania grup1984
Thymosins: structure, function and therapeutic applications.ThymusBez losowania grup1984
Thymalfasin, a promising adjuvant therapy in small hepatocellular carcinoma after liver resection.Medicine (Baltimore)Obserwacja grupy2017
PRaG5.0 combined with chemotherapy and sequential chemoimmunotherapy for massive SMARCA4-deficient undifferentiated tumor of the cervix: case report.Front ImmunolOpisy przypadków2026
A case report of successful combined intra-arterial immunotherapy and cytokine genetic therapy treatment in a patient with recurrent glioblastoma.Chin Clin OncolOpisy przypadków2024
PD-1 inhibitor combined with SBRT, GM-CSF, and thymosin alpha-1 in metastatic breast cancer: A case report and literature review.Medicine (Baltimore)Opisy przypadków2024
Palliative care and Chinese medicine in a centenarian with primary hepatocellular carcinoma and 27-month follow-up: A case report.HeliyonOpisy przypadków2023
Long-term asymptomatic SARS-CoV-2 infection associated with deficiency on multiple immune cells.Biosaf HealthOpisy przypadków2022
Postpartum extracorporeal membrane oxygenation of a woman with COVID-19-related acute respiratory distress syndrome: A case report.Medicine (Baltimore)Opisy przypadków2021
Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.Medicine (Baltimore)Opisy przypadków2020
Severe Gastric Mycormycosis Infection Followed by Cytomegalovirus Pneumonia in a Renal Transplant Recipient: A Case Report and Concise Review of the Literature.Transplant ProcOpisy przypadków2019
Chronic active EBV infection associated with NK cell lymphoma and hemophagocytic lymphohistiocytosis in a 27-year-old woman: A case report.Medicine (Baltimore)Opisy przypadków2019
Stage IV Wilms Tumor Treated by Korean Medicine, Hyperthermia and Thymosin-α1: A Case Report.Case Rep OncolOpisy przypadków2016
[The therapeutic effect of high flow nasal cannula oxygen therapy for the first imported case of Middle East respiratory syndrome to China].Zhonghua Wei Zhong Bing Ji Jiu Yi XueOpisy przypadków2015
[Clinical analysis of the first patient with imported Middle East respiratory syndrome in China].Zhonghua Wei Zhong Bing Ji Jiu Yi XueOpisy przypadków2015
The role of Tα1 on the infective patients after hematopoietic stem cell transplantation.Int J HematolOpisy przypadków2013
[Clinicopathological characterization of prostatic small cell carcinoma: a case report and review of the literature].Zhonghua Nan Ke XueOpisy przypadków2009
[Clinical investigation of outbreak of nosocomial severe acute respiratory syndrome].Zhongguo Wei Zhong Bing Ji Jiu Yi XueOpisy przypadków2003
Chronic hepatitis B: current and future treatment options.PharmacotherapyOpisy przypadków2002
Emergence of an S gene mutant during thymosin alpha1 therapy in a patient with chronic hepatitis B.J Infect DisOpisy przypadków1998
Thymic carcinoma of the thyroid.Pathol IntOpisy przypadków1996
Malignant thymoma associated with T-cell lymphocytosis. A case report with immunophenotypic and gene rearrangement analysis.Arch Pathol Lab MedOpisy przypadków1993
Bone marrow transplantation in DiGeorge syndrome.J PediatrOpisy przypadków1987
Intestinal lymphangiectasia and thymic hypoplasia.Clin Exp ImmunolOpisy przypadków1985
Pure RBC aplasia and myasthenia gravis. Coexistence of two diseases associated with thymoma.Arch Intern MedOpisy przypadków1983
Thymosin α-1 in cancer therapy: Immunomodulatory mechanisms, clinical applications, and translational perspectives.Eur J PharmacolPrzegląd badań2026
Clinical Applications and Evidence Landscape of Thymosin Alpha 1 as an Immunomodulatory Adjunct in Cancer Care: A Scoping Review.Pharmaceuticals (Basel)Przegląd badań2026
Thymosin α1 combined with immune checkpoint inhibitors: synergistic remodeling of the tumor immune microenvironment to enhance clinical efficacy and safety.Front ImmunolPrzegląd badań2026
Comparative efficacy and safety of immunomodulatory therapies for sepsis: a systematic review and network meta-analysis.Front Med (Lausanne)Przegląd badań2026
Peptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulation.Integr Med (Encinitas)Przegląd badań2026
Drug Repurposing in Oncology: A Strategic Pathway to Unlocking New Therapeutic Potential.Ther Innov Regul SciPrzegląd badań2026
Aging and Thymosin Alpha-1.Int J Mol SciPrzegląd badań2025
T-cell immunobiology and cytokine storm of COVID-19.Prog Mol Biol Transl SciPrzegląd badań2025
Phenotypic drug discovery: a case for thymosin alpha-1.Front Med (Lausanne)Przegląd badań2024
Comprehensive Review of the Safety and Efficacy of Thymosin Alpha 1 in Human Clinical Trials.Altern Ther Health MedPrzegląd badań2024
Therapeutic applications of thymosin peptides: a patent landscape 2018-present.Expert Opin Ther PatPrzegląd badań2023
Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors.Cancer Biol MedPrzegląd badań2023
Mechanism and clinical application of thymosin in the treatment of lung cancer.Front ImmunolPrzegląd badań2023
Thymosin α1 and Its Role in Viral Infectious Diseases: The Mechanism and Clinical Application.MoleculesPrzegląd badań2023
COVID-19 and beyond: Reassessing the role of thymosin alpha1 in lung infections.Int ImmunopharmacolPrzegląd badań2023
Theory and reality of antivirals against SARS-CoV-2.World J Clin CasesPrzegląd badań2021
Immunomodulatory agents as potential therapeutic or preventive strategies for COVID-19.Eur Rev Med Pharmacol SciPrzegląd badań2021
The right immune-modulation at the right time: thymosin α1 for prevention of severe COVID-19 in cancer patients.Future OncolPrzegląd badań2021
T cell immunobiology and cytokine storm of COVID-19.Scand J ImmunolPrzegląd badań2021
COVID-19: Imbalanced Immune Responses and Potential Immunotherapies.Front ImmunolPrzegląd badań2020
Thymosin alpha 1: A comprehensive review of the literature.World J VirolPrzegląd badań2020
Covid-19-Associated Pulmonary Aspergillosis: The Other Side of the Coin.Vaccines (Basel)Przegląd badań2020
Pharmacological development of the potential adjuvant therapeutic agents against coronavirus disease 2019.J Chin Med AssocPrzegląd badań2020
Pharmacological and Genomic Approaches in Management of Cystic Fibrosis.Crit Rev Eukaryot Gene ExprPrzegląd badań2020
A Reappraisal of Thymosin Alpha1 in Cancer Therapy.Front OncolPrzegląd badań2019
Thymosins in multiple sclerosis and its experimental models: moving from basic to clinical application.Mult Scler Relat DisordPrzegląd badań2019
Cellular proteostasis: a new twist in the action of thymosin α1.Expert Opin Biol TherPrzegląd badań2018
Thymosin alpha 1 treatment for patients with sepsis.Expert Opin Biol TherPrzegląd badań2018
Unmet needs in cystic fibrosis.Expert Opin Biol TherPrzegląd badań2018
Serum thymosin alpha 1 levels in normal and pathological conditions.Expert Opin Biol TherPrzegląd badań2018
Potential mechanism of thymosin-α1-membrane interactions leading to pleiotropy: experimental evidence and hypotheses.Expert Opin Biol TherPrzegląd badań2018
The effect of thymosin α1 for prevention of infection in patients with severe acute pancreatitis.Expert Opin Biol TherPrzegląd badań2018
Immunotherapy for hepatitis B in the direct acting antiviral era: Reevaluating the thymosin α1 efficacy trials in the light of a combination therapy approach.J Viral HepatPrzegląd badań2018
Thymosin alpha 1 and HIV-1: recent advances and future perspectives.Future MicrobiolPrzegląd badań2017
Immune Modulation with Thymosin Alpha 1 Treatment.Vitam HormPrzegląd badań2016
Phosphorylation of Prothymosin α. An Approach to Its Biological Significance.Vitam HormPrzegląd badań2016
Structures of Thymosin Proteins.Vitam HormPrzegląd badań2016
Historical review on thymosin α1 in oncology: preclinical and clinical experiences.Expert Opin Biol TherPrzegląd badań2015
Immunomodulatory adjuvant therapy in severe community-acquired pneumonia.Expert Rev Respir MedPrzegląd badań2014
Lung cancer chemotherapy, new treatment and related patents.Recent Pat Anticancer Drug DiscovPrzegląd badań2014
Thymosin α1 as a stimulatory agent of innate cell-mediated immune response.Ann N Y Acad SciPrzegląd badań2012
Thymosin α1 in melanoma: from the clinical trial setting to the daily practice and beyond.Ann N Y Acad SciPrzegląd badań2012
Thymosin α1 and cancer: action on immune effector and tumor target cells.Ann N Y Acad SciPrzegląd badań2012
Jack of all trades: thymosin α1 and its pleiotropy.Ann N Y Acad SciPrzegląd badań2012
Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy.Cancer Immunol ImmunotherPrzegląd badań2012
Medical management of chronic liver diseases in children (part I): focus on curable or potentially curable diseases.Paediatr DrugsPrzegląd badań2011
Utility of thymosin alpha-1 (Zadaxin) as a co-adjuvant in influenza vaccines: a review.J Prev Med HygPrzegląd badań2011
Preclinical studies with IRX-2 and thymosin alpha1 in combination therapy.Ann N Y Acad SciPrzegląd badań2010
Thymosin alpha1 to harness immunity to pathogens after haploidentical hematopoietic transplantation.Ann N Y Acad SciPrzegląd badań2010
Thymalfasin in the treatment of hepatitis B and C.Ann N Y Acad SciPrzegląd badań2010
Thymosin alpha 1 for treatment of hepatitis C virus: promise and proof.Ann N Y Acad SciPrzegląd badań2010
Thymosin alpha 1: past clinical experience and future promise.Ann N Y Acad SciPrzegląd badań2010
Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha-1.Ann N Y Acad SciPrzegląd badań2010
Thymosin alpha1: the regulator of regulators?Ann N Y Acad SciPrzegląd badań2010
Treatment with lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B patients: a meta-analysis.Virol JPrzegląd badań2009
From lab to bedside: emerging clinical applications of thymosin alpha 1.Expert Opin Biol TherPrzegląd badań2009
Thymosin alpha1: a promising molecule for important clinical applications.Med ArhPrzegląd badań2009
Neuropeptides and thymic hormones in the Xenopus thymus.Front Biosci (Landmark Ed)Przegląd badań2009
Provision of antifungal immunity and concomitant alloantigen tolerization by conditioned dendritic cells in experimental hematopoietic transplantation.Blood Cells Mol DisPrzegląd badań2008
Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance.Ann N Y Acad SciPrzegląd badań2007
beta-Thymosins.Ann N Y Acad SciPrzegląd badań2007
Thymic reticulo-epithelial cells: key cells of neuroendocrine regulation.Expert Opin Biol TherPrzegląd badań2007
Thymalfasin for the treatment of chronic hepatitis C infection.Expert Rev Anti Infect TherPrzegląd badań2005
Thymalfasin (thymosin-alpha 1) therapy in patients with chronic hepatitis B.J Gastroenterol HepatolPrzegląd badań2004
Thymalfasin: an immune system enhancer for the treatment of liver disease.J Gastroenterol HepatolPrzegląd badań2004
Thymalfasin (thymosin-alpha 1) therapy in patients with chronic hepatitis B.J Gastroenterol HepatolPrzegląd badań2004
Thymalfasin: an immune system enhancer for the treatment of liver disease.J Gastroenterol HepatolPrzegląd badań2004
Past, present, and future hepatitis C treatments.Semin Liver DisPrzegląd badań2004
Current therapy and new molecular approaches to antiviral treatment and prevention of hepatitis C.Rev Med VirolPrzegląd badań2003
Thymosin in the treatment of HBeAg-negative chronic hepatitis B.Med Sci MonitPrzegląd badań2003
T cell targeted immune enhancement yields effective T cell adjuvants.Int ImmunopharmacolPrzegląd badań2003
Combination therapy in the treatment of chronic viral hepatitis and prevention of hepatocellular carcinoma.Int ImmunopharmacolPrzegląd badań2003
Thymosin alpha(1) in combination with cytokines and chemotherapy for the treatment of cancer.Int ImmunopharmacolPrzegląd badań2003
Immunodeficiency and cancer: prospects for correction.Int ImmunopharmacolPrzegląd badań2003
A novel porcine interleukin-2-interferon-α-thymosin α1 tripartite fusion protein confers antiviral activity against pseudorabies virus.Vet MicrobiolNa zwierzętach2026
Thymosin α1 alleviates lung injury in sepsis rats via Notch signaling pathway.Panminerva MedNa zwierzętach2023
Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1.J Thromb HaemostNa zwierzętach2023
Immunological effects of heated intraperitoneal chemotherapy can be augmented by thymosin α1.Int ImmunopharmacolNa zwierzętach2023
[Structural changes and functional evaluation of the thymus in aging mouse induced by D-galactose].Xi Bao Yu Fen Zi Mian Yi Xue Za ZhiNa zwierzętach2022
Thymosin alpha 1 as an adjuvant to hyperthermic intraperitoneal chemotherapy in an experimental model of peritoneal metastases from colonic carcinoma.Int ImmunopharmacolNa zwierzętach2022
Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities.PhytochemistryNa zwierzętach2022
Hormonal Regulation of the MHC Class I Gene in Thyroid Cells: Role of the Promoter "Tissue-Specific" Region.Front Endocrinol (Lausanne)Na zwierzętach2021
Zuogui Wan alleviated maternal kidney-yin deficiency-induced thymic epithelial cell dysfunction in newborn rats through Wnt/β-catenin signaling pathway.J EthnopharmacolNa zwierzętach2021
DNA Dendrons as Agents for Intracellular Delivery.J Am Chem SocNa zwierzętach2021
PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology.Int J Mol SciNa zwierzętach2020
Improvement in cognitive dysfunction following blast induced traumatic brain injury by thymosin α1 in rats: Involvement of inhibition of tau phosphorylation at the Thr205 epitope.Brain ResNa zwierzętach2020
Thymosin α1 protects from CTLA-4 intestinal immunopathology.Life Sci AllianceNa zwierzętach2020
Immunopotentiator thymosin alpha-1 attenuates inflammatory pain by modulating the Wnt3a/β-catenin pathway in spinal cord.NeuroreportNa zwierzętach2020
Fusion of thymosin alpha 1 with mutant IgG1 CH3 prolongs half-life and enhances antitumor effects in vivo.Int ImmunopharmacolNa zwierzętach2019
Thymosin Alpha-1 Inhibits Complete Freund's Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord.Neurosci BullNa zwierzętach2019
Effect of a C-end rule modification on antitumor activity of thymosin α1.BiochimieNa zwierzętach2018
Gene cloning, expression and immune adjuvant properties of the recombinant fusion peptide Tα1-BLP on avian influenza inactivate virus vaccine.Microb PathogNa zwierzętach2018
Effect of Boron on Thymic Cytokine Expression, Hormone Secretion, Antioxidant Functions, Cell Proliferation, and Apoptosis Potential via the Extracellular Signal-Regulated Kinases 1 and 2 Signaling Pathway.J Agric Food ChemNa zwierzętach2017
Immunopotentiator Thymosin Alpha-1 Promotes Neurogenesis and Cognition in the Developing Mouse via a Systemic Th1 Bias.Neurosci BullNa zwierzętach2017
Investigation of the immunomodulatory activity of Tricholoma matsutake mycelium in cyclophosphamide-induced immunosuppressed mice.Mol Med RepNa zwierzętach2017
[The Effects of Thymosin alpha1 on Immune Function of Mice after Skin Transplantation].Sichuan Da Xue Xue Bao Yi Xue BanNa zwierzętach2015
Efficacy of thymosin α1 and interferon α for the treatment of severe acute pancreatitis in a rat model.Mol Med RepNa zwierzętach2015
Thymosin α1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1.Biochem Biophys Res CommunNa zwierzętach2015
[Triplet anti-tumor therapy based on thymosin α-1 attenuates incidence of hepatoma and serum alpha-fetoprotein level in rat hepatoma model].Xi Bao Yu Fen Zi Mian Yi Xue Za ZhiNa zwierzętach2015
Immunogenicity in Swine of Orally Administered Recombinant Lactobacillus plantarum Expressing Classical Swine Fever Virus E2 Protein in Conjunction with Thymosin α-1 as an Adjuvant.Appl Environ MicrobiolNa zwierzętach2015
Evaluation of thymosin α 1 in nonclinical models of the immune-suppressing indications melanoma and sepsis.Expert Opin Biol TherNa zwierzętach2015
[Effects of thymosin alpha1 on immune effector molecules of mouse].Sichuan Da Xue Xue Bao Yi Xue BanNa zwierzętach2014
Combination therapy with thymosin alpha1 and dexamethasone helps mice survive sepsis.InflammationNa zwierzętach2014
The in vivo immunomodulatory and synergistic anti-tumor activity of thymosin α1-thymopentin fusion peptide and its binding to TLR2.Cancer LettNa zwierzętach2013
Thymosin α1 continues to show promise as an enhancer for vaccine response.Ann N Y Acad SciNa zwierzętach2012
[Ulinastatin combined with thymosin α1 for treatment of severe sepsis: a histopathological observation in rats].Nan Fang Yi Ke Da Xue Xue BaoNa zwierzętach2012
The use of growth factors to modulate the activities of antigen-specific CD8+ T cells in vitro.J Med LifeNa zwierzętach2011
Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice.Front Biosci (Landmark Ed)Na zwierzętach2011
Thymosin alpha 1: biological activities, applications and genetic engineering production.PeptidesNa zwierzętach2010
In vitro and in vivo study of thymosin alpha1 biodegradable in situ forming poly(lactide-co-glycolide) implants.Int J PharmNa zwierzętach2010
[Purification of recombinant proteins with an example of tumor necrosis factor thymosin-alpha1].Prikl Biokhim MikrobiolNa zwierzętach2010
Intraperitoneal co-administration of thymosin alpha-1 ameliorates streptozotocin-induced pancreatic lesions and diabetes in C57BL/6 mice.Int J Mol MedNa zwierzętach2009
Expression of thymosin alpha1-thymopentin fusion peptide in Pichia pastoris and its characterization.Arch Pharm ResNa zwierzętach2008
Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells.Cell Biol IntNa zwierzętach2008
Expression and analysis of thymosin alpha1 concatemer in Escherichia coli.Biotechnol Appl BiochemNa zwierzętach2008
Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum level.J Gastroenterol HepatolNa zwierzętach2007
Thymosin alpha1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo.Int ImmunolNa zwierzętach2007
Thymosin alpha 1: from bench to bedside.Ann N Y Acad SciNa zwierzętach2007
Thymosin alpha1 as a chemopreventive agent in lung and breast cancer.Ann N Y Acad SciNa zwierzętach2007
Studies of bioactivity, conformation and pharmacokinetic profiles of site-specific PEGylated thymosin alpha 1 derivatives.Drug Metab LettNa zwierzętach2007
Solid-phase synthesis of a peptide derivative of thymosin alpha1 and initial studies on its (99m)Tc-radiolabelling.Chem Biol Drug DesNa zwierzętach2007
[Preparation and properties of Talpha1 loaded injectable sustained release microspheres].Yao Xue Xue BaoNa zwierzętach2007
Construction and application of a yeast expression system for thymosin alpha1.BiocellNa zwierzętach2005
Immunomodulatory function of orally administered thymosin alpha1.J Zhejiang Univ Sci BNa zwierzętach2005
Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway.EMBO RepNa zwierzętach2005
Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats.Clin BiochemNa zwierzętach2005
[Combination of lamivudine with thymosin alpha1 in treatment of duck hepatitis B].Zhejiang Da Xue Xue Bao Yi Xue BanNa zwierzętach2005
Construction and expression of a new fusion protein, thymosin alpha1-cBLyS, E. coli.Biotechnol LettNa zwierzętach2005
Antitumor activation of peritoneal macrophages by thymosin alpha-1.Cancer InvestNa zwierzętach2005
Avian thymic hormone treatment of peripheral blood mononuclear cells from young chicks stimulates acute graft-versus-host reaction in chicken embryos.Dev Comp ImmunolNa zwierzętach2005
[Effect of thymosin alpha1 on immunological function and metabolism in peritoneal sepsis rats].Zhonghua Wai Ke Za ZhiNa zwierzętach2004
Effect of thymosin alpha 1 on the antitumor activity of tumor-associated macrophage-derived dendritic cells.J Biomed SciNa zwierzętach2004
Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling.BloodNa zwierzętach2004
Thymosin α1-induced secretion of the IL-15/RA complex by THP-1-derived dendritic cells restrains HIV latency in vitro.VirulenceW probówce2026
Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.Sci RepW probówce2019
Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.JCI InsightW probówce2018
Thymosin alpha1 enhanced cytotoxicity of iNKT cells against colon cancer via upregulating CD1d expression.Cancer LettW probówce2015
The modulation of thymosin alpha 1 in the maturation, differentiation and function of murine bone marrow-derived dendritic cells in the absence or presence of tumor necrosis factor-alpha.Int ImmunopharmacolW probówce2004
Thymosin alpha1 is a time and dose-dependent antagonist of dexamethasone-induced apoptosis of murine thymocytes in vitro.Int J ImmunopharmacolW probówce2000
Thymosin-alpha1 stimulates maturation of CD34+ stem cells into CD3+4+ cells in an in vitro thymic epithelia organ coculture model.Int J ImmunopharmacolW probówce1999
[The effect of complete thymic extract on motility and progressive motility of spermatozoa in asthenozoospermia].Srp Arh Celok LekW probówce1996
Thymosin alpha-1 and FA-1 monoclonal antibody affect murine preimplantation embryo development by modulating protein phosphorylation.J Reprod ImmunolW probówce1995
Effect of thymosin alpha 1 on hypothalamic hormone release.NeuroendocrinologyW probówce1992
Solid-phase syntheses of two deacetyl-thymosin alpha 1 analogues with substitution at position 21 and their effects on low E-rosette-forming lymphocytes of uremic patients.Biotechnol TherW probówce1992
Synthesis of an immunologically active fragment analog of prothymosin alpha with enhanced enzymatic stability.Chem Pharm Bull (Tokyo)W probówce1991
The octapeptide corresponding to the region of the highest homology between alpha-interferon and thymosin-alpha 1 effectively competes with both cytokines for common high-affinity receptors on murine thymocytes.FEBS LettW probówce1991
Thymosin alpha 1 and thymosin beta 4 modulate human colonic lamina propria lymphocyte function.ImmunopharmacologyW probówce1990
Thymosin alpha 1 enhancement of human lymphocyte proliferation is not mediated by prostaglandin E2.ThymusW probówce1990
Phytohemagglutin-stimulated human T cell: prothymosin alpha as an accessory signal.J Biol Regul Homeost AgentsW probówce1990
Thymosin enhances the production of IL-1 alpha by human peripheral blood monocytes.Lymphokine ResW probówce1989
Thymosins alpha 1 and beta 4 potentiate the antigen-presenting capacity of macrophages.ImmunopharmacologyW probówce1989
Aspirin and thymosin increase interleukin-2 and interferon-gamma production by human peripheral blood lymphocytes.ImmunopharmacologyW probówce1989
Interaction of thymic peptide thymosin alpha 1 with VIP receptors in rat intestinal epithelial cells: comparison with PHI and secretin.Gen PharmacolW probówce1989
Production of human B and T cell growth factors is enhanced by thymic hormones.ImmunopharmacologyW probówce1988
Encapsulated thymic epithelial cells as a potential treatment for immunodeficiencies.ASAIO TransW probówce1988
MicroELISA detection of thymosin alpha 1 released in thymic organ cultures.J Immunol MethodsW probówce1988
Micro ELISA for measurement of parathymosin alpha utilizing a monoclonal antibody.ThymusW probówce1988
Phase II trial of thymosin fraction 5 and thymosin alpha 1.J Biol Response ModW probówce1987
Immunoregulatory effects of fraction 5 thymus peptides. I. Thymosin alpha 1 enhances while thymosin beta 4 suppresses the human autologous and allogeneic mixed lymphocyte reaction.ImmunopharmacologyW probówce1987
Effect of two thymosin fraction 5 polypeptides on human peripheral blood lymphocytes.Immunopharmacol ImmunotoxicolW probówce1987
Circulating thymulin and thymosin-alpha 1 activity in pediatric acquired immune deficiency syndrome: in vivo and in vitro studies.J PediatrW probówce1986
Comparison of the effects of thymosin and other thymic factors on modulation of interleukin-2 production.J Biol Response ModW probówce1985
Interleukin-2 and aging: decreased interleukin-2 production in healthy older people does not correlate with reduced helper cell numbers or antibody response to influenza vaccine and is not corrected in vitro by thymosin alpha 1.ImmunopharmacologyW probówce1985
Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis.Adv Sci (Weinh)Inna praca2026
Thymosin Alpha-1 Restores Chemotherapy-Induced Antitumor Immunity by Chaperoning a MicroRNA Ligand of TLR7 in Dendritic Cells.Cancer ResInna praca2026
A prospective clinical study on the effectiveness of Phellinus igniarius decoction in treating immune dysfunction in colorectal cancer patients following chemfotherapy.J Tradit Complement MedInna praca2026
[Risk factors of death in patients with bloodstream infections in a medical intensive care unit].Zhonghua Wei Zhong Bing Ji Jiu Yi XueInna praca2026
Thymosin α1 Augments CD8⁺ T-Cell Activation and Reverses Exhaustion In Vitro.Asian Pac J Cancer PrevInna praca2026
IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8+ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression.J Gastroenterol HepatolInna praca2026
Thymalfasin combined with immune checkpoint inhibitors in the treatment of non-small cell lung cancer: A retrospective study on efficacy, safety, and immunological function.Pak J Med SciInna praca2026
A multipronged Tα1 reset of CD8+ T cell cytotoxicity against breast cancer.Hum ImmunolInna praca2026
A Case Report of a Multisystemic Immune-Related Adverse Event Caused by Sintilimab in Combination With Thymosin Alpha-1.Clin Case RepInna praca2026
Zerumbone mediated CD1d inhibition suppresses epithelial to mesenchymal transition in triple negative breast cancer.Discov OncolInna praca2026
Thymosin α1 Combined with PD-1/PD-L1 Inhibitor Plus Chemotherapy in Platinum-Resistant Recurrent Ovarian Cancer : A Retrospective Analysis.Cancer Manag ResInna praca2025
Exploiting the potential of in situ forming liquid crystals: development and in vitro performance of long-acting depots for peptide drug thymosin alpha 1 subcutaneous administration.Drug DelivInna praca2025
Cross-Expression of Thymic and Parathyroid Hormone Receptors Supports the Hypothesis of a Parathyroid-Thymus Port System.Int J Mol SciInna praca2025
MRAP mediated adipocyte differentiation by thymic mesenchymal stromal cells contributes to thymic involution.Nat CommunInna praca2025
Thymosin α1 Elevates Lymphocyte Counts and Improves Immunoradiotherapy Outcomes in Patients with Advanced Cancer.Cancer Manag ResInna praca2025
Thymosin α1 alleviates pulpitis by inhibiting ferroptosis of dental pulp cells.Int J Oral SciInna praca2025
Thymosin α1 Combined With 2HRZE/4HR Regimen as a Potential Treatment of Pulmonary Tuberculosis: An Analysis of Immune Function, Pulmonary Function and Inflammatory Response.Br J Hosp Med (Lond)Inna praca2025
Expression levels of thymosin α1 in acute myocardial infarction patients and its correlation to cardiac function.Front Cardiovasc MedInna praca2025
The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets.Onco Targets TherInna praca2025
Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma.iScienceInna praca2025
A preliminary analysis of integrating thymosin α1 into concurrent chemoradiotherapy and consolidative immunotherapy in unresectable locally advanced non-small cell lung cancer.Transl Lung Cancer ResInna praca2025
The Synergistic and Attenuated Mechanism of Action of the Xihuang Pill in Dual Immunotherapy After Stenting for Advanced Cholangiocarcinoma: A Controlled Clinical Trial.Int J Gen MedInna praca2025
Effect of thymosin α1 on Immune response and organ function in acute aortic dissection surgery: PANDA II trial protocol.Future CardiolInna praca2025
The efficacy and safety of thymosin alpha-1 combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a retrospective study.Sci RepInna praca2025
Synergistic effects of recombinant expressed Fowlicidin and Thymosin α1 hybrid peptides in modulating inflammation and infection in avian macrophages.Front MicrobiolInna praca2025
Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.Brain Behav Immun HealthInna praca2025
Unveiling lymphocyte dynamics: Navigating postoperative immune landscapes in gastric cancer patients undergoing laparoscopic D2 gastrectomy.Int J Immunopathol PharmacolInna praca2025
Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8+CD69+ T cells.J Immunother CancerInna praca2024
Effect analysis of entecavir on serum hyaluronic acid, laminin and IV collagen in the treatment of hepatitis B E-antigen-positive chronic hepatitis B.Afr Health SciInna praca2024
Single-cell RNA sequencing combined with proteomics of infected macrophages reveals prothymosin-α as a target for treatment of apical periodontitis.J Adv ResInna praca2024
Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy.Cell Rep MedInna praca2024
N-Butylpyrrolidinone is an equally good solvent as N,N-dimethylformamide for microwave assisted solid phase peptide synthesis.J Pept SciInna praca2024
Effect of thymalfasin on myeloid-derived suppressor cells in patients with non-small cell lung cancer.Am J Transl ResInna praca2024
Thymosin α1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery.Open Life SciInna praca2024
Efficacy of the combination of BRII-196/BRII-198 in the treatment of COVID-19 vaccine breakthrough infections.Am J Transl ResInna praca2024
Evaluation of the efficacy and safety of a precise thymalfasin-regulated PRaG regimen for advanced refractory solid tumours: protocol for the open-label, prospective, multicentre study (PRaG5.0 study).BMJ OpenInna praca2024
Robust Chemical Synthesis of "Difficult Peptides" via 2-Hydroxyphenol-pseudoproline (ψ2-hydroxyphenolpro) Modifications.J Org ChemInna praca2024
Enhanced Immunomodulatory Effects of Thymosin-Alpha-1 in Combination with Polyanionic Carbosilane Dendrimers against HCMV Infection.Int J Mol SciInna praca2024
Role of thymosin α1 in restoring immune response in immunological nonresponders living with HIV.BMC Infect DisInna praca2024
Immune modulation via dendritic cells by the effect of Thymosin-alpha-1 on immune synapse in HCMV infection.Int ImmunopharmacolInna praca2023
Thymosin α1 modulated the immune landscape of COVID-19 patients revealed by single-cell RNA and TCR sequencing.Int ImmunopharmacolInna praca2023
Thymalfasin therapy accelerates COVID-19 pneumonia rehabilitation through anti-inflammatory mechanisms.Pneumonia (Nathan)Inna praca2023
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2.Immun AgeingInna praca2023
Zoledronic acid and thymosin α1 elicit antitumor immunity against prostate cancer by enhancing tumor inflammation and cytotoxic T cells.J Immunother CancerInna praca2023
Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment?Int ImmunopharmacolInna praca2023
Thymosin α1 interacts with Galectin-1 modulating the β-galactosides affinity and inducing alteration in the biological activity.Int ImmunopharmacolInna praca2023
Thymosin alpha 1 restores the immune homeostasis in lymphocytes during Post-Acute sequelae of SARS-CoV-2 infection.Int ImmunopharmacolInna praca2023
Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: a post-hoc analysis of the multicentre, randomised, placebo-controlled TRACE trial.EClinicalMedicineInna praca2023
Novel evidence of Thymosin α1 immunomodulatory properties in SARS-CoV-2 infection: Effect on innate inflammatory response in a peripheral blood mononuclear cell-based in vitro model.Int ImmunopharmacolInna praca2023
Adenovirus infection diagnosed by metagenomic next-generation sequencing after haploidentical hematopoietic stem cell transplantation: A multicenter study in China.Transpl Infect DisInna praca2023
Thymosin alpha 1 - Reimagine its broader applications in the immuno-oncology era.Int ImmunopharmacolInna praca2023
Thymosin α-1 in cancer therapy: Immunoregulation and potential applications.Int ImmunopharmacolInna praca2023
Higher plasma levels of thymosin-α1 are associated with a lower waning of humoral response after COVID-19 vaccination: an eight months follow-up study in a nursing home.Immun AgeingInna praca2023
Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients.Front ImmunolInna praca2023
Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C.Open Life SciInna praca2023
A Pilot Trial of Thymalfasin (Thymosin-α-1) to Treat Hospitalized Patients With Hypoxemia and Lymphocytopenia Due to Coronavirus Disease 2019 Infection.J Infect DisInna praca2023

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Zarejestrowane badania na ludziach (61)

BadaniaEtapStatusLiczba uczestnikówAktualizacja
Thymalfasin Combined With Chemotherapy and Immunotherapy in TNBC Neoadjuvant TreatmentEtap 2Jeszcze nie ruszyło5722026-10-20
Thymosin-α1 for Recurrent Implantation FailureEtap 2, Etap 3Szuka uczestników1362026-10-15
Thymalfasin for Immune Recovery in Adults With Sepsis–Szuka uczestników602026-10-08
Protective Effect of Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)–Zakończone6002026-09-14
Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal CancerEtap 2Jeszcze nie ruszyło312026-08-21
The Impact of Thymosin α-1 on the Efficacy of Concurrent Chemoradiotherapy Followed by Immunotherpay Consolidation for Locally Advanced NSCLCEtap 2Zakończone1142026-08-03
Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 VaccineEtap 1Szuka uczestników752026-07-16
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for Locally Advanced Mid-low Rectal Cancer–Zakończone472026-06-18
Thymosin Alpha 1 Combined With Anti-PD-1 Monoclonal Antibody in Elderly Patients With Advanced MelanomaEtap 2Szuka uczestników552026-06-12
Thymosin Alpha 1 to Prevent COVID-19 Infection in Renal Dialysis PatientsEtap 2Zakończone1892026-04-21
Phase II Trial of Neoadjuvant Thymalfasin, PD-1 Inhibitor, and Chemoradiotherapy for cStage III GEJ AdenocarcinomaEtap 2Szuka uczestników482026-03-19
Efficacy and Safety of Anti-PD-1, Thymalfasin, and SOX in Neoadjuvant Treatment of cStage III Gastric/Gastroesophageal Junction AdenocarcinomaEtap 2Szuka uczestników302026-03-03
AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection–Jeszcze nie ruszyło3002026-02-02
Protective Effect of Ulinastatin and Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA XI)–Na zaproszenie2002026-01-14
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal CancerEtap 2Trwa, bez nowych osób202025-04-02
"Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"Etap 2Szuka uczestników522025-02-17
Neoadjuvant With Tα1 Plus Immuno-chemotherapy for Resectable NSCLC–Nieznany402024-09-23
Thymalfasin and Recombinant Human IL-2 Injections in Treating Lymphocytopenia for Patients With Malignant Hematological TumorsEtap 2Szuka uczestników502024-09-19
Immuno-effect of Tα1 for Stage I NSCLC–Nieznany402024-09-19
Radiotherapy With Sequential Chemotherapy Combined With PD-1 Inhibitor and Thymalfasin for BRPCEtap 2Jeszcze nie ruszyło202024-08-27
Thymosin Alpha-1 for irAE Secondary to ICIsEtap 4Nieznany402023-12-20
Abscopal Effect for Metastatic Colorectal CancerEtap 2Wycofane02023-09-21
Zadaxin and HIV-positive Patients With Immune Reconstitution DisorderWczesny etap 1Zakończone202023-07-18
The Efficacy and Safety of Ta1 for SepsisEtap 3Zakończone11062023-04-10
Thymalfasin-based PRaG Mode for Advanced Refractory Solid TumorsEtap 2Nieznany602023-03-30
Thymalfasin (Thymosin Alpha 1) to Treat COVID-19 InfectionEtap 2Przerwane562023-02-14
Platform Adaptive Embedded Trial for Acute Respiratory Distress SyndromeEtap 4Nieznany10002022-12-21
Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass–Nieznany2002022-08-04
Study of Thymosin α1 to Reduce Acute Pneumonia For Bulky None-small Cell Lung CancerEtap 2Zakończone692022-01-03
Thymosin-alpha 1 for Adjuvant Treatment After Radical Resection of High-risk Stage II and III Colorectal CancerEtap 3Szuka uczestników25002021-10-21
The Efficacy and Safety of Thymosin-α1 in Patients With HBV-related ACLF–Zakończone1202021-08-16
Long-term Prognosis of Patients With Sepsis After Immunotherapy–Jeszcze nie ruszyło9002021-05-25
Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing PancreatitisEtap 4Zakończone5082021-04-05
Immunotherapy for Elderly Patients With Chronic Osteoporotic PainEtap 4Nieznany1002020-08-26
Experimental Trial of rhIFNα Nasal Drops to Prevent 2019-nCOV in Medical StaffEtap 3Nieznany29442020-03-31
Efficacy of Thymosin Alpha 1 on Improving Monocyte Function for SepsisEtap 4Zakończone202019-04-04
Abscopal Effect for Metastatic Non-small Cell Lung Cancer.Etap 2Wycofane02019-03-26
Abscopal Effect for Metastatic Small Cell Lung CancerEtap 2Wycofane02019-03-21
Optimized Treatment and Regression of HBV-induced Early CirrhosisEtap 4Zakończone822018-07-27
Optimized Treatment and Regression of HBV-induced Compensated Liver CirrhosisEtap 4Zakończone6062018-07-27
Efficacy and Safety of Combination Therapy of Thymalfasin and Entecavir in HBeAg-positive ETV-experienced PatientsEtap 4Nieznany2402018-02-28
SBRT Combined With Thymalfasin for Metastatic Esophageal CancerEtap 2Nieznany292017-11-28
SBRT Combination With rhGM-CSF and Tα1 for Stage IV NSCLC Patients Who Failed in Second-line ChemotherapyEtap 2Nieznany482016-11-29
Radiotherapy Combined With Thymosin for Metastatic NSCLC Patients Who Showed Stable Disease After First Line TKI TherapyEtap 2Nieznany462016-11-25
Thymosin Alpha 1 Plus Maintenance Therapy With the Standard of Care (SoC) in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC), EGFR Wild TypeEtap 2Nieznany1402016-09-19
First Line Bio-immunotherapy With Thymosin Alpha 1 in Patients With Sensitizing EGFR Mutation Positive Non Small Cell Lung Cancer Who Are Taking Standard of Care TherapyEtap 1, Etap 2Nieznany1882016-09-19
Therapeutic Safety and Efficacy of REP 2139 (REP 9AC') in HBV Infected PatientsEtap 1, Etap 2Zakończone122016-01-05
Phase II Trial for Combination Treatment of PEG-Tα1 and Adefovir for HBeAg Positive Chronic Hepatitis BEtap 2Zakończone1162015-02-19
Phase Ⅲ Trial for Combination Treatment of PEG-Tα1 and Adefovir for HBeAg-positive Chronic Hepatitis BEtap 3Nieznany4632015-02-19
Thymalfasin Adjuvant Therapy in Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (HCC) After Curative ResectionEtap 4Nieznany3602014-11-21
Dendritic Cell Based Therapy for Breast Cancer PatientsEtap 2Wycofane02012-05-31
A Pilot Study to Evaluate ZADAXIN's® (Thymalfasin) Ability to Enhance Immune Response to the H1N1sw Influenza VaccineEtap 2Zakończone1202012-03-29
Efficacy Study of Thymosin alpha1 & Pegylated Interferon-alpha2a to Treat Chronic Hepatitis BEtap 4Zakończone522011-07-21
Efficacy of Thymosin alpha1 for Severe Sepsis–Zakończone3662011-06-14
Thymosin Alpha-1 in Combination With Peg-Interferon Alfa- 2a and Ribavirin for the Therapy of Chronic Hepatitis C Nonresponsive to the Combination of IFN and Ribavirin.Etap 3Zakończone5522010-08-10
Thymosin Alpha 1, Interferon Alpha, or Both, in Combination With Dacarbazine in Patients With Malignant MelanomaEtap 2Zakończone4882009-07-09
The Safety and Effectiveness of a Type of Interleukin-2 Plus Zidovudine Plus Thymosin in HIV-Positive Patients With and Without Symptoms of InfectionEtap 1Zakończone122008-07-30
Thymosin Plus PEG-Interferon in Hepatitis C Patients With Cirrhosis Who Did Not Respond to Interferon or Interferon Plus RibavirinEtap 3Zakończone5002008-01-15
Thymosin Plus PEG-Interferon in Non-Cirrhotic Hepatitis C Patients Who Did Not Respond to Interferon or Interferon Plus RibavirinEtap 3Zakończone5002008-01-15
A Trial of Thymalfasin in Adult Patients With Hepatocellular CarcinomaEtap 2Zakończone–2008-01-15
Thymosin Alfa 1 in Recipients of Allogeneic Hematopoietic Transplantation for Hematological MalignanciesEtap 1, Etap 2Nieznany92007-12-24