Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjects.Eur J EndocrinolZ losowaniem grup2005
The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients with longstanding post-irradiation GH insufficiency.Eur J EndocrinolZ losowaniem grup2000
The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostatin(1-14)(SS) in growth hormone (GH) pulse generation: studies in normal and post cranial irradiated individuals.Clin Endocrinol (Oxf)Z losowaniem grup1999
The control on growth hormone release by free fatty acids is maintained in acromegaly.J Clin Endocrinol MetabZ losowaniem grup1999
Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation.J Clin Endocrinol MetabZ losowaniem grup1998
Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion.Clin Endocrinol (Oxf)Z losowaniem grup1998
Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women.J Clin Endocrinol MetabZ losowaniem grup1997
Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study.J Clin Endocrinol MetabZ losowaniem grup1996
The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity.Clin Endocrinol (Oxf)Z losowaniem grup1996
Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuli.J Clin InvestZ losowaniem grup1996
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.Domest Anim EndocrinolZ losowaniem grup1996
Comparison of the effects of growth hormone-releasing hormone and hexarelin, a novel growth hormone-releasing peptide-6 analog, on growth hormone secretion in humans with or without glucocorticoid excess.J EndocrinolZ losowaniem grup1995
Role of galanin in the regulation of somatotrope and gonadotrope function in young ovulatory women.MetabolismZ losowaniem grup1995
Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects.J Clin Endocrinol MetabZ losowaniem grup1994
Low-dose growth hormone-releasing hormone tests: a dose-response study.Eur J EndocrinolZ losowaniem grup1994
Effect of pyridostigmine on the growth hormone response to growth hormone-releasing hormone in lean and obese type II Diabetic patients.MetabolismZ losowaniem grup1994
Physiological role of galanin in the regulation of anterior pituitary function in humans.Am J PhysiolZ losowaniem grup1994
A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiency.Acta Paediatr SupplZ losowaniem grup1993
Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormone.Acta Paediatr SupplZ losowaniem grup1993
Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration.Acta Paediatr SupplZ losowaniem grup1993
Effect of galanin on the growth hormone (GH) response to GH-releasing hormone in patients with Cushing's disease.Endocr ResZ losowaniem grup1993
Galanin does not affect the growth hormone-releasing hormone-stimulated growth hormone secretion in patients with hyperthyroidism.Acta Endocrinol (Copenh)Z losowaniem grup1992
Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.J Clin Endocrinol MetabZ losowaniem grup1992
Effects of exogenous growth hormone pretreatment on the pituitary growth hormone response to growth hormone-releasing hormone alone or in combination with pyridostigmine in type I diabetic patients.Acta Endocrinol (Copenh)Z losowaniem grup1991
Pyridostigmine fails to increase either spontaneous or GHRH-stimulated GH secretion during day or night in growth hormone-insufficient children.Clin Endocrinol (Oxf)Z losowaniem grup1991
Impaired growth hormone (GH) response to pyridostigmine in type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion.J Clin Endocrinol MetabZ losowaniem grup1990
The interaction between clonidine and growth hormone releasing hormone in the stimulation of growth hormone secretion in man.Clin Endocrinol (Oxf)Z losowaniem grup1990
Subcutaneous growth hormone-releasing hormone augments pulsatile nocturnal GH release in GH-insufficient children, but may also raise basal GH secretion.Clin Endocrinol (Oxf)Z losowaniem grup1990
Acute effects of cortisone acetate on growth hormone response to growth hormone-releasing hormone in normal adult subjects.Acta Endocrinol (Copenh)Z losowaniem grup1990
Evaluation of the growth-hormone-releasing hormone test in short normal and growth-hormone-deficient children.Horm ResZ losowaniem grup1990
Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers.Clin Endocrinol (Oxf)Z losowaniem grup1987
Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects.Clin Endocrinol (Oxf)Z losowaniem grup1986
Influence of dopaminergic, adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1-29.Clin Endocrinol (Oxf)Z losowaniem grup1986
Outcome of growth hormone therapy in children with growth hormone deficiency showing an inadequate response to growth hormone-releasing hormone.EndocrineBez losowania grup2001
The negative GH auto-feedback in childhood: effects of rhGH and/or GHRH on the somatotroph response to GHRH or hexarelin, a peptidyl GH secretagogue, in children.J Endocrinol InvestBez losowania grup2000
Interaction of the growth hormone releasing peptide hexarelin with somatostatin.Clin Endocrinol (Oxf)Bez losowania grup1997
Growth hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemia.J Pediatr Endocrinol MetabBez losowania grup1997
Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.MetabolismBez losowania grup1997
Long-term administration of acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid in obesity.MetabolismBez losowania grup1996
Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.J Clin Endocrinol MetabBez losowania grup1996
Plasma GH responses to human GHRH-antagonist in normal subjects.Eur J EndocrinolBez losowania grup1996
Acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid levels in hyperthyroidism.MetabolismBez losowania grup1995
The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency.J Clin Endocrinol MetabBez losowania grup1995
The effect of a continuous infusion of a somatostatin analogue (octreotide) for two years on growth hormone secretion and height prediction in tall children.Clin Endocrinol (Oxf)Bez losowania grup1995
Reciprocal relationship between the level of circulating cortisol and growth hormone secretion in response to growth hormone-releasing hormone in man: studies in patients with adrenal insufficiency.J Clin Endocrinol MetabBez losowania grup1994
Priming with GHRH (1-29) NH2: an aid in differential diagnosis between hypothalamic and pituitary deficiencies.J Pediatr EndocrinolBez losowania grup1994
Long-term therapy with a single daily subcutaneous dose of growth hormone releasing hormone (1-29) in prepubertal growth hormone deficient children. Venezuelan Collaborative Study Group.J Pediatr EndocrinolBez losowania grup1994
Study on growth hormone and insulin secretion in myotonic dystrophy.Clin InvestigBez losowania grup1994
Variability in the growth hormone response to growth hormone-releasing hormone alone or combined with pyridostigmine in type 1 diabetic patients.J Endocrinol InvestBez losowania grup1993
Growth hormone (GH) profiles in response to continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 in children with GH deficiency.Acta Paediatr SupplBez losowania grup1993
Intranasal administration of growth hormone-releasing hormone(1-29)-NH2 in children with growth hormone deficiency: effects on growth hormone secretion and growth.Acta Paediatr SupplBez losowania grup1993
Glucocorticoids may inhibit growth hormone release by enhancing beta-adrenergic responsiveness in hypothalamic somatostatin neurons.J Clin Endocrinol MetabBez losowania grup1993
The interaction of GHRH with TRH in acromegaly: a controlled study.Acta Endocrinol (Copenh)Bez losowania grup1991
Clonidine pretreatment modifies the growth hormone secretory pattern induced by short-term continuous GRF infusion in normal man.Clin Endocrinol (Oxf)Bez losowania grup1991
Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men.J Clin Endocrinol MetabBez losowania grup1991
The role of cholinergic tone in modulating the growth hormone response to growth hormone-releasing hormone in normal man.MetabolismBez losowania grup1991
The growth hormone response to pyridostigmine plus growth hormone releasing hormone is not influenced by pubertal maturation.J Endocrinol InvestBez losowania grup1991
Inhibitory effect of calcitonin on growth hormone response to growth hormone releasing hormone in acromegaly.Braz J Med Biol ResBez losowania grup1991
Alpha 2-adrenergic agonism enhances the growth hormone (GH) response to GH-releasing hormone through an inhibition of hypothalamic somatostatin release in normal men.J Clin Endocrinol MetabBez losowania grup1990
Effects of GRF (1-29) NH2 on short-term memory: neuroendocrine and neuropsychological assessment in healthy young subjects.Methods Find Exp Clin PharmacolBez losowania grup1990
Growth hormone response to overnight growth hormone-releasing hormone infusion and oral pyridostigmine in children with short stature.Acta Paediatr Scand SupplBez losowania grup1989
GH feedback occurs through modulation of hypothalamic somatostatin under cholinergic control: studies with pyridostigmine and GHRH.Clin Endocrinol (Oxf)Bez losowania grup1987
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.Front SurgOpisy przypadków2026
GHRH excess and blockade in X-LAG syndrome.Endocr Relat CancerOpisy przypadków2016
Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist.J Clin Endocrinol MetabOpisy przypadków1997
Coexistence of growth hormone-secreting pituitary adenoma and intracranial meningioma: a case report and review of the literature.J Endocrinol InvestOpisy przypadków1993
Discordance between growth hormone responses after growth hormone-releasing hormone (GHRH) and insulin hypoglycemia in ectopic GHRH syndrome.Endocrinol ExpOpisy przypadków1990
Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.Sex Med RevPrzegląd badań2026
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Front Endocrinol (Lausanne)Przegląd badań2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res RevPrzegląd badań2026
Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.Transl Androl UrolPrzegląd badań2020
PEGylation of growth hormone-releasing hormone (GRF) analogues.Adv Drug Deliv RevPrzegląd badań2003
Growth hormone-releasing peptides: clinical and basic aspects.Horm ResPrzegląd badań1996
Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency.Acta Paediatr Scand SupplPrzegląd badań1987
An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma.Drug Test AnalNa zwierzętach2019
Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors.HippocampusNa zwierzętach2014
Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities.PeptidesNa zwierzętach2014
Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission.HippocampusNa zwierzętach2009
Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12).Bioconjug ChemNa zwierzętach2007
Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss).Comp Biochem Physiol A Mol Integr PhysiolNa zwierzętach2007
Interactions of GRF(1-29)NH2 with plasma proteins and their effects on the release of the peptide from a PLAGA matrix.J Control ReleaseNa zwierzętach2005
Regulation of renal NaPi-2 expression and tubular phosphate reabsorption by growth hormone in the juvenile rat.Am J Physiol Renal PhysiolNa zwierzętach2004
Development of an enzyme-linked immunosorbent assay for the measurement of plasma growth hormone (GH) levels in channel catfish (Ictalurus punctatus): assessment of environmental salinity and GH secretogogues on plasma GH levels.Gen Comp EndocrinolNa zwierzętach2003
Localization and regulation of a functional GHRH receptor in the rat renal medulla.EndocrinologyNa zwierzętach2002
Transcriptional and post-transcriptional regulation of tyrosine hydroxylase messenger RNA in PC12 cells during persistent stimulation by VIP and PACAP38: differential regulation by protein kinase A and protein kinase C-dependent pathways.NeuropeptidesNa zwierzętach2002
Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.Proc Natl Acad Sci U S ANa zwierzętach2002
GH gene expression in the submaxillary gland in normal and Ames dwarf mice.J EndocrinolNa zwierzętach2001
The hexapeptide KP-102 (D-ala-D-beta-Nal-ala-trp-D-phe-lys-NH(2)) stimulates growth hormone release in a cichlid fish (Ooreochromis mossambicus).J EndocrinolNa zwierzętach2000
VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation.Eur J NeurosciNa zwierzętach2000
Effect of long-term GHRH and somatostatin administration on GH release and body weight in prepubertal female rats.J Physiol BiochemNa zwierzętach1999
Differential in vivo regulation of the pituitary growth hormone-releasing hormone (GHRH) receptor by GHRH in young and aged rats.EndocrinologyNa zwierzętach1999
Feeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion.J Anim SciNa zwierzętach1998
Effect of growth hormone-releasing peptide 1-6 on GH secretion-stimulated by GHRH and pyridostigmine in lambs.J Physiol BiochemNa zwierzętach1998
VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells.J BiochemNa zwierzętach1998
In vivo effects of the GH-releasing heptapeptide GHRP-1 in lambs.Reprod Nutr DevNa zwierzętach1998
The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I.Am J PhysiolNa zwierzętach1997
Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on hormone secretion from sheep pituitary cells in vitro.J NeuroendocrinolNa zwierzętach1997
Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages.Eur J PharmacolNa zwierzętach1997
Expression of vasoactive intestinal polypeptide receptor mRNA and secretory regulation by vasoactive intestinal polypeptide in rat submandibular and sublingual salivary glands.Arch Oral BiolNa zwierzętach1997
Pituitary adenylate cyclase-activating peptide stimulates amylase release and cyclic adenosine monophosphate production in pancreatic acinar cells.SurgeryNa zwierzętach1996
Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptides (PACAP27) and PACAP38) protect CD4+CD8+ thymocytes from glucocorticoid-induced apoptosis.BloodNa zwierzętach1996
The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs.J EndocrinolNa zwierzętach1996
Somatostatin increases growth hormone (GH) secretion in a subpopulation of porcine somatotropes: evidence for functional and morphological heterogeneity among porcine GH-producing cells.EndocrinologyNa zwierzętach1996
Long-term alterations in growth hormone and insulin secretion after temporary dietary protein restriction in early life in the rat.Pediatr ResNa zwierzętach1995
Pituitary adenylate cyclase-activating polypeptides (PACAP27 and PACAP38) inhibit the mobility of murine thymocytes and splenic lymphocytes: comparison with VIP and implication of cAMP.J NeuroimmunolNa zwierzętach1995
Effect of long-acting antagonists of growth hormone (GH)-releasing hormone on GH and cyclic adenosine 3',5'-monophosphate release in superfused rat pituitary cells.EndocrinologyNa zwierzętach1995
The involvement of dipeptidyl peptidase IV in brush-border degradation of GRF(1-29)NH2 by intestinal mucosal cells.J Pharm PharmacolNa zwierzętach1995
Effects of acute administration of growth hormone-releasing hormone (GHRH) and oxytocin on somatotroph cells in sheep: morphometric study and growth hormone (GH) secretion.J Endocrinol InvestNa zwierzętach1995
Interaction between adrenergic and peptide stimulation in the rat pineal: pituitary adenylate cyclase-activating peptide.J NeurochemNa zwierzętach1995
The effect of GHRH on TSH release in rats in vivo and in vitro.J Endocrinol InvestNa zwierzętach1995
Inhibitory effect of vasoactive intestinal peptide (VIP) on phagocytosis in mouse peritoneal macrophages.Regul PeptNa zwierzętach1994
Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist.NeuropeptidesNa zwierzętach1994
Subcellular distribution of proteolytic activities degrading bioactive peptides and analogues in the rat small intestinal and colonic enterocytes.J Pharm PharmacolNa zwierzętach1994
Early increase in pulsatile growth hormone release after unilateral nephrectomy in adult rats.Am J PhysiolNa zwierzętach1994
Effects in vitro of new growth hormone releasing peptide (GHRP-1) on growth hormone secretion from ovine pituitary cells in primary culture.J NeuroendocrinolNa zwierzętach1994
The effect of GH-releasing peptide-2 (GHRP-2 or KP 102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist.J EndocrinolNa zwierzętach1994
Effect of somatotropin and/or equine chorionic gonadotropin on serum and follicular insulin-like growth factor I and insulin-like growth factor binding proteins in cattle.Biol ReprodNa zwierzętach1994
Lack of evidence for acute effects of growth hormone-releasing hormone on serum insulin and glucose levels in normal and hypophysectomized rats.Horm ResNa zwierzętach1994
Feedlot performance, carcass characteristics, hormones, and metabolites in steers actively immunized against growth hormone-releasing factor.J Anim SciNa zwierzętach1993
Effects of growth hormone-releasing factor and(or) thyrotropin-releasing hormone on growth, feed efficiency, carcass characteristics, and blood hormones and metabolites in beef heifers.J Anim SciNa zwierzętach1993
Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal.J Pineal ResNa zwierzętach1993
A new target for growth hormone releasing-hormone action in rat: the Sertoli cell.EndocrinologyNa zwierzętach1993
The entire vasoactive intestinal polypeptide molecule is required for the activation of the vasoactive intestinal polypeptide receptor: functional and binding studies on opossum internal anal sphincter smooth muscle.J Pharmacol Exp TherNa zwierzętach1993
Interaction of ovine pituitary adenylate cyclase-activating peptide (PACAP-38) with rat lung membranes.PeptidesNa zwierzętach1993
Comparison of the insulinotropic activity of glucagon-superfamily peptides in rat pancreas perfusion.Horm Metab ResNa zwierzętach1992
Lactation performance of sows injected with growth hormone-releasing factor during gestation and(or) lactation.J Anim SciNa zwierzętach1992
Catabolism of rat growth hormone-releasing factor(1-29) amide in rat serum and liver.PeptidesNa zwierzętach1992
Effect of iontophoresis on in vitro skin permeation of an analogue of growth hormone releasing factor in the hairless guinea pig model.J Pharm SciNa zwierzętach1992
Evaluation of the biological potency of new agmatine analogs of growth hormone-releasing hormone in the bovine.Proc Soc Exp Biol MedNa zwierzętach1992
Effect of prepartum administration of growth hormone-releasing factor on somatotropin, insulin-like growth factor I, milk production, and postpartum return to ovarian activity in primiparous beef heifers.J Anim SciNa zwierzętach1992
Role of selected endogenous peptides in growth hormone-releasing hexapeptide activity: analysis of growth hormone-releasing hormone, thyroid hormone-releasing hormone, and gonadotropin-releasing hormone.EndocrinologyNa zwierzętach1992
Effect of active immunization against growth hormone releasing factor on concentrations of somatotropin and insulin-like growth factor I in lactating beef cows.Domest Anim EndocrinolNa zwierzętach1992
Time-dependent reduction and potentiation of growth hormone (GH) responsiveness to GH-releasing factor induced by exogenous GH: role for somatostatin.EndocrinologyNa zwierzętach1992
Advances in the detection of growth hormone releasing hormone synthetic analogs.Drug Test AnalW probówce2021
The use of pigs as an animal model to evaluate the efficacy, potency and specificity of two growth hormone releasing factor analogues.Growth Horm IGF ResW probówce2001
Antagonistic analogs of growth hormone releasing hormone (GHRH) inhibit cyclic AMP production of human cancer cell lines in vitro.PeptidesW probówce1999
Effects of peptide T derivatives on the proliferation of cultured human keratinocytes.ArzneimittelforschungW probówce1995
Characterization of growth hormone-releasing hormone (GHRH) binding to cloned porcine GHRH receptor.PeptidesW probówce1995
VIP antagonists enhance excitatory cholinergic neurotransmission in the human airway.LungW probówce1994
Effects of vasoactive intestinal polypeptide antagonists on cholinergic neurotransmission in dog and cat trachea.Br J PharmacolW probówce1991
VIP-ergic and cholinergic innervations in internal carotid arteries of the cat and rat.J Cardiovasc PharmacolW probówce1991
A comparison of the biological activities of authentic rat GRF(1-43)OH with the analogue rat GRF(1-29)NH2.Can J Physiol PharmacolW probówce1991
Analogues of growth hormone-releasing factor (1-29) amide containing the reduced peptide bond isostere in the N-terminal region.J Med ChemW probówce1990
A glucagon-secretin-like peptide stimulates the intrinsic nervous plexus of guinea pig gallbladder.ExperientiaW probówce1990
Secretory actions of vasoactive intestinal polypeptide, peptide histidine isoleucine and helodermin in rat small intestine: the effects of putative VIP antagonists upon VIP-induced ion secretion.Regul PeptW probówce1989
Analogues of vasoactive intestinal peptide (VIP) contract the guinea-pig uterine artery but do not antagonize VIP-induced relaxations.Eur J PharmacolW probówce1989
The effects of vasoactive intestinal peptide (VIP) antagonists, and VIP and peptide histidine isoleucine antisera on non-adrenergic, non-cholinergic relaxations of tracheal smooth muscle.Br J PharmacolW probówce1989
The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways.PeptidesW probówce1988
The synthetic peptide GRF (1-29)-NH2 with growth hormone releasing activity penetrates human epidermis in nitro.Acta Pharm SuecW probówce1988
Differential effects of N-terminal modifications on the biological potencies of growth hormone releasing factor analogues with varying chain lengths.J Med ChemW probówce1987
Specific labelling of high-affinity vasoactive intestinal peptide receptors in rat liver membranes by a growth hormone-releasing factor analog.NeuroendocrinologyW probówce1986
Comparative structural requirements of thirty GRF analogs for interaction with GRF- and VIP receptors and coupling to adenylate cyclase in rat adenopituitary, liver and pancreas.PeptidesW probówce1986
Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist.EndocrinologyW probówce1985
Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.J Pharm Biomed AnalInna praca2026
Universal peptide synthesis via solid-phase methods fused with chemputation.Nat CommunInna praca2025
Chromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control urine samples.J Mass SpectromInna praca2024
Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.Anal BiochemInna praca2023
In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.Biomed ChromatogrInna praca2023
Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis.ElectrophoresisInna praca2023
Probing for peptidic drugs (2-10 kDa) in doping control blood samples.Anal Sci AdvInna praca2022
An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS.J Pharm Biomed AnalInna praca2022
A potentially effective drug for patients with recurrent glioma: sermorelin.Ann Transl MedInna praca2021
Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.J Chromatogr AInna praca2020
Exploring the Conformational Space of Growth-Hormone-Releasing Hormone Analogues Using Dopant Assisted Trapped Ion Mobility Spectrometry-Mass Spectrometry.J Phys Chem BInna praca2019
Glycine-modified growth hormone secretagogues identified in seized doping material.Drug Test AnalInna praca2019
Structural Motif Descriptors as a Way To Elucidate the Agonistic or Antagonistic Activity of Growth Hormone-Releasing Hormone Peptide Analogues.ACS OmegaInna praca2018
Growth hormone-releasing hormone (GHRH) and its agonists inhibit hepatic and tumoral secretion of IGF-1.OncotargetInna praca2018
Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.Am J Mens HealthInna praca2017
Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth.PeptidesInna praca2017
Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.Anal Bioanal ChemInna praca2016
Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe.Drug Test AnalInna praca2016
Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS.Drug Test AnalInna praca2015
The GHRH + arginine stimulated pituitary GH secretion in children and adults with Prader-Willi syndrome shows age- and BMI-dependent and genotype-related differences.Growth Horm IGF ResInna praca2013
Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency.J Clin Endocrinol MetabInna praca2013
Growth hormone-releasing hormone receptor splice variant 1 is frequently expressed in oral squamous cell carcinomas.Horm CancerInna praca2012
GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells.Cell CycleInna praca2011
Activation of mitogen-activated protein kinases by a splice variant of GHRH receptor.J Mol EndocrinolInna praca2010
Repetitive stimulation of the pituitary with growth-hormone-releasing hormone alters the proportion of 22 and 20 kilodalton human-growth hormone released.Int J Pediatr EndocrinolInna praca2010
Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro.NeuropeptidesInna praca2009
Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist.Oncol RepInna praca2008
Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines.Br J CancerInna praca2008
Lipopeptide antagonists of growth hormone-releasing hormone with improved antitumor activities.Proc Natl Acad Sci U S AInna praca2006
Antagonist of growth hormone-releasing hormone induces apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway.Proc Natl Acad Sci U S AInna praca2005
Chromatographic separation and mass spectrometric identification of positional isomers of polyethylene glycol-modified growth hormone-releasing factor (1-29).J Chromatogr AInna praca2004
Pharmacodynamic evaluation of a PEGylated analogue of human growth hormone releasing factor in rats and pigs.Growth Horm IGF ResInna praca2004
Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes.J EndocrinolInna praca2002
The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas.Proc Natl Acad Sci U S AInna praca2002
[Effect of transdermal administration of 17-beta estradiol on the release of growth hormone by growth hormone liberating hormone (GH-RH-1-29) in climacteric women before and after treatment].Ginecol Obstet MexInna praca2001
Contribution of growth hormone-releasing hormone and somatostatin to decreased growth hormone secretion in elderly men.S Afr Med JInna praca2001
Growth during and after a trial of growth hormone releasing hormone 1-29 in children with idiopathic short stature or growth hormone neurosecretory dysfunction.J Pediatr Endocrinol MetabInna praca2000
Interaction of the novel GH secretagogue hexarelin with GHRH in regulating the secretion of GH by cultured human pituitary somatotrophinomas in vitro.J Tongji Med UnivInna praca2000
Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma.Proc Natl Acad Sci U S AInna praca1999
In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans: evidence for relative GHRH deficiency in aging.J Clin Endocrinol MetabInna praca1999
Predicting bull growth performance and carcass composition from growth hormone response to growth hormone-releasing hormone.J Anim SciInna praca1999
Effects of active immunization against growth-hormone releasing factor on puberty and reproductive development in gilts.J Anim SciInna praca1999
Functional characterization of a receptor for vasoactive-intestinal-peptide-related peptides in cultured dermal melanophores from Xenopus laevis.Pigment Cell ResInna praca1999
Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers.J Clin Endocrinol MetabInna praca1999
The growth hormone response to hexarelin in patients with Prader-Willi syndrome.J Endocrinol InvestInna praca1998
Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells.EndocrineInna praca1998
Presence of GHRH mRNA in human pituitary somatotrophinomas and its relationship to in vitro effect of a GHRH-antagonist on GH secretion and cAMP production.PituitaryInna praca1998
Human growth hormone-releasing hormone hGHRH(1-29)-NH2: systematic structure-activity relationship studies.J Med ChemInna praca1998
New analogs of human growth hormone-releasing hormone (1-29) with high and prolonged antagonistic activity.J Pept ResInna praca1998
Treatment of radiation-induced growth hormone deficiency with growth hormone-releasing hormone.Clin Endocrinol (Oxf)Inna praca1997
Inhibitory effects of galanin on growth hormone (GH) release in cultured GH-secreting adenoma cells: comparative study with octreotide, GH-releasing hormone, and thyrotropin-releasing hormone.MetabolismInna praca1997
Glutamate decarboxylase autoimmunity and growth hormone secretion in type I diabetes mellitus.MetabolismInna praca1997
Presence of a bioactive and immunoreactive growth-hormone-releasing-factor-like substance in porcine placenta.Biol NeonateInna praca1997
Nocturnal growth hormone (GH) secretion is eliminated by infusion of GH-releasing hormone antagonist.J Clin Endocrinol MetabInna praca1996
Growth hormone response to growth hormone-releasing hormone varies with the hypothalamic-pituitary abnormalities.Eur J EndocrinolInna praca1996
Evaluation of growth hormone (GH) responses to pulsed GH-releasing hormone administration using the MTT-ESTA bioassay.Eur J EndocrinolInna praca1996
Hypothalamic control of growth hormone (GH) secretion in type I diabetic men: effect of the combined administration of GH-releasing hormone and hexarelin, a novel GHRP-6 analog.Endocr ResInna praca1996
Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.Eur J PharmacolInna praca1996

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