Graded
The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
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Sermorelin

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Scientific papers

StudiesKind of studyYear
Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjects.Eur J EndocrinolRandom groups2005
The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients with longstanding post-irradiation GH insufficiency.Eur J EndocrinolRandom groups2000
The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostatin(1-14)(SS) in growth hormone (GH) pulse generation: studies in normal and post cranial irradiated individuals.Clin Endocrinol (Oxf)Random groups1999
The control on growth hormone release by free fatty acids is maintained in acromegaly.J Clin Endocrinol MetabRandom groups1999
Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation.J Clin Endocrinol MetabRandom groups1998
Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion.Clin Endocrinol (Oxf)Random groups1998
Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women.J Clin Endocrinol MetabRandom groups1997
Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study.J Clin Endocrinol MetabRandom groups1996
The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity.Clin Endocrinol (Oxf)Random groups1996
Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuli.J Clin InvestRandom groups1996
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.Domest Anim EndocrinolRandom groups1996
Comparison of the effects of growth hormone-releasing hormone and hexarelin, a novel growth hormone-releasing peptide-6 analog, on growth hormone secretion in humans with or without glucocorticoid excess.J EndocrinolRandom groups1995
Role of galanin in the regulation of somatotrope and gonadotrope function in young ovulatory women.MetabolismRandom groups1995
Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects.J Clin Endocrinol MetabRandom groups1994
Low-dose growth hormone-releasing hormone tests: a dose-response study.Eur J EndocrinolRandom groups1994
Effect of pyridostigmine on the growth hormone response to growth hormone-releasing hormone in lean and obese type II Diabetic patients.MetabolismRandom groups1994
Physiological role of galanin in the regulation of anterior pituitary function in humans.Am J PhysiolRandom groups1994
A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiency.Acta Paediatr SupplRandom groups1993
Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormone.Acta Paediatr SupplRandom groups1993
Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration.Acta Paediatr SupplRandom groups1993
Effect of galanin on the growth hormone (GH) response to GH-releasing hormone in patients with Cushing's disease.Endocr ResRandom groups1993
Galanin does not affect the growth hormone-releasing hormone-stimulated growth hormone secretion in patients with hyperthyroidism.Acta Endocrinol (Copenh)Random groups1992
Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.J Clin Endocrinol MetabRandom groups1992
Effects of exogenous growth hormone pretreatment on the pituitary growth hormone response to growth hormone-releasing hormone alone or in combination with pyridostigmine in type I diabetic patients.Acta Endocrinol (Copenh)Random groups1991
Pyridostigmine fails to increase either spontaneous or GHRH-stimulated GH secretion during day or night in growth hormone-insufficient children.Clin Endocrinol (Oxf)Random groups1991
Impaired growth hormone (GH) response to pyridostigmine in type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion.J Clin Endocrinol MetabRandom groups1990
The interaction between clonidine and growth hormone releasing hormone in the stimulation of growth hormone secretion in man.Clin Endocrinol (Oxf)Random groups1990
Subcutaneous growth hormone-releasing hormone augments pulsatile nocturnal GH release in GH-insufficient children, but may also raise basal GH secretion.Clin Endocrinol (Oxf)Random groups1990
Acute effects of cortisone acetate on growth hormone response to growth hormone-releasing hormone in normal adult subjects.Acta Endocrinol (Copenh)Random groups1990
Evaluation of the growth-hormone-releasing hormone test in short normal and growth-hormone-deficient children.Horm ResRandom groups1990
Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers.Clin Endocrinol (Oxf)Random groups1987
Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects.Clin Endocrinol (Oxf)Random groups1986
Influence of dopaminergic, adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1-29.Clin Endocrinol (Oxf)Random groups1986
Outcome of growth hormone therapy in children with growth hormone deficiency showing an inadequate response to growth hormone-releasing hormone.EndocrineNo random groups2001
The negative GH auto-feedback in childhood: effects of rhGH and/or GHRH on the somatotroph response to GHRH or hexarelin, a peptidyl GH secretagogue, in children.J Endocrinol InvestNo random groups2000
Interaction of the growth hormone releasing peptide hexarelin with somatostatin.Clin Endocrinol (Oxf)No random groups1997
Growth hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemia.J Pediatr Endocrinol MetabNo random groups1997
Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.MetabolismNo random groups1997
Long-term administration of acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid in obesity.MetabolismNo random groups1996
Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.J Clin Endocrinol MetabNo random groups1996
Plasma GH responses to human GHRH-antagonist in normal subjects.Eur J EndocrinolNo random groups1996
Acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid levels in hyperthyroidism.MetabolismNo random groups1995
The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency.J Clin Endocrinol MetabNo random groups1995
The effect of a continuous infusion of a somatostatin analogue (octreotide) for two years on growth hormone secretion and height prediction in tall children.Clin Endocrinol (Oxf)No random groups1995
Reciprocal relationship between the level of circulating cortisol and growth hormone secretion in response to growth hormone-releasing hormone in man: studies in patients with adrenal insufficiency.J Clin Endocrinol MetabNo random groups1994
Priming with GHRH (1-29) NH2: an aid in differential diagnosis between hypothalamic and pituitary deficiencies.J Pediatr EndocrinolNo random groups1994
Long-term therapy with a single daily subcutaneous dose of growth hormone releasing hormone (1-29) in prepubertal growth hormone deficient children. Venezuelan Collaborative Study Group.J Pediatr EndocrinolNo random groups1994
Study on growth hormone and insulin secretion in myotonic dystrophy.Clin InvestigNo random groups1994
Variability in the growth hormone response to growth hormone-releasing hormone alone or combined with pyridostigmine in type 1 diabetic patients.J Endocrinol InvestNo random groups1993
Growth hormone (GH) profiles in response to continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 in children with GH deficiency.Acta Paediatr SupplNo random groups1993
Intranasal administration of growth hormone-releasing hormone(1-29)-NH2 in children with growth hormone deficiency: effects on growth hormone secretion and growth.Acta Paediatr SupplNo random groups1993
Glucocorticoids may inhibit growth hormone release by enhancing beta-adrenergic responsiveness in hypothalamic somatostatin neurons.J Clin Endocrinol MetabNo random groups1993
The interaction of GHRH with TRH in acromegaly: a controlled study.Acta Endocrinol (Copenh)No random groups1991
Clonidine pretreatment modifies the growth hormone secretory pattern induced by short-term continuous GRF infusion in normal man.Clin Endocrinol (Oxf)No random groups1991
Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men.J Clin Endocrinol MetabNo random groups1991
The role of cholinergic tone in modulating the growth hormone response to growth hormone-releasing hormone in normal man.MetabolismNo random groups1991
The growth hormone response to pyridostigmine plus growth hormone releasing hormone is not influenced by pubertal maturation.J Endocrinol InvestNo random groups1991
Inhibitory effect of calcitonin on growth hormone response to growth hormone releasing hormone in acromegaly.Braz J Med Biol ResNo random groups1991
Alpha 2-adrenergic agonism enhances the growth hormone (GH) response to GH-releasing hormone through an inhibition of hypothalamic somatostatin release in normal men.J Clin Endocrinol MetabNo random groups1990
Effects of GRF (1-29) NH2 on short-term memory: neuroendocrine and neuropsychological assessment in healthy young subjects.Methods Find Exp Clin PharmacolNo random groups1990
Growth hormone response to overnight growth hormone-releasing hormone infusion and oral pyridostigmine in children with short stature.Acta Paediatr Scand SupplNo random groups1989
GH feedback occurs through modulation of hypothalamic somatostatin under cholinergic control: studies with pyridostigmine and GHRH.Clin Endocrinol (Oxf)No random groups1987
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.Front SurgCase reports2026
GHRH excess and blockade in X-LAG syndrome.Endocr Relat CancerCase reports2016
Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist.J Clin Endocrinol MetabCase reports1997
Coexistence of growth hormone-secreting pituitary adenoma and intracranial meningioma: a case report and review of the literature.J Endocrinol InvestCase reports1993
Discordance between growth hormone responses after growth hormone-releasing hormone (GHRH) and insulin hypoglycemia in ectopic GHRH syndrome.Endocrinol ExpCase reports1990
Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.Sex Med RevReview of studies2026
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Front Endocrinol (Lausanne)Review of studies2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res RevReview of studies2026
Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.Transl Androl UrolReview of studies2020
PEGylation of growth hormone-releasing hormone (GRF) analogues.Adv Drug Deliv RevReview of studies2003
Growth hormone-releasing peptides: clinical and basic aspects.Horm ResReview of studies1996
Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency.Acta Paediatr Scand SupplReview of studies1987
An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma.Drug Test AnalIn animals2019
Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors.HippocampusIn animals2014
Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities.PeptidesIn animals2014
Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission.HippocampusIn animals2009
Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12).Bioconjug ChemIn animals2007
Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss).Comp Biochem Physiol A Mol Integr PhysiolIn animals2007
Interactions of GRF(1-29)NH2 with plasma proteins and their effects on the release of the peptide from a PLAGA matrix.J Control ReleaseIn animals2005
Regulation of renal NaPi-2 expression and tubular phosphate reabsorption by growth hormone in the juvenile rat.Am J Physiol Renal PhysiolIn animals2004
Development of an enzyme-linked immunosorbent assay for the measurement of plasma growth hormone (GH) levels in channel catfish (Ictalurus punctatus): assessment of environmental salinity and GH secretogogues on plasma GH levels.Gen Comp EndocrinolIn animals2003
Localization and regulation of a functional GHRH receptor in the rat renal medulla.EndocrinologyIn animals2002
Transcriptional and post-transcriptional regulation of tyrosine hydroxylase messenger RNA in PC12 cells during persistent stimulation by VIP and PACAP38: differential regulation by protein kinase A and protein kinase C-dependent pathways.NeuropeptidesIn animals2002
Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.Proc Natl Acad Sci U S AIn animals2002
GH gene expression in the submaxillary gland in normal and Ames dwarf mice.J EndocrinolIn animals2001
The hexapeptide KP-102 (D-ala-D-beta-Nal-ala-trp-D-phe-lys-NH(2)) stimulates growth hormone release in a cichlid fish (Ooreochromis mossambicus).J EndocrinolIn animals2000
VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation.Eur J NeurosciIn animals2000
Effect of long-term GHRH and somatostatin administration on GH release and body weight in prepubertal female rats.J Physiol BiochemIn animals1999
Differential in vivo regulation of the pituitary growth hormone-releasing hormone (GHRH) receptor by GHRH in young and aged rats.EndocrinologyIn animals1999
Feeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion.J Anim SciIn animals1998
Effect of growth hormone-releasing peptide 1-6 on GH secretion-stimulated by GHRH and pyridostigmine in lambs.J Physiol BiochemIn animals1998
VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells.J BiochemIn animals1998
In vivo effects of the GH-releasing heptapeptide GHRP-1 in lambs.Reprod Nutr DevIn animals1998
The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I.Am J PhysiolIn animals1997
Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on hormone secretion from sheep pituitary cells in vitro.J NeuroendocrinolIn animals1997
Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages.Eur J PharmacolIn animals1997
Expression of vasoactive intestinal polypeptide receptor mRNA and secretory regulation by vasoactive intestinal polypeptide in rat submandibular and sublingual salivary glands.Arch Oral BiolIn animals1997
Pituitary adenylate cyclase-activating peptide stimulates amylase release and cyclic adenosine monophosphate production in pancreatic acinar cells.SurgeryIn animals1996
Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptides (PACAP27) and PACAP38) protect CD4+CD8+ thymocytes from glucocorticoid-induced apoptosis.BloodIn animals1996
The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs.J EndocrinolIn animals1996
Somatostatin increases growth hormone (GH) secretion in a subpopulation of porcine somatotropes: evidence for functional and morphological heterogeneity among porcine GH-producing cells.EndocrinologyIn animals1996
Long-term alterations in growth hormone and insulin secretion after temporary dietary protein restriction in early life in the rat.Pediatr ResIn animals1995
Pituitary adenylate cyclase-activating polypeptides (PACAP27 and PACAP38) inhibit the mobility of murine thymocytes and splenic lymphocytes: comparison with VIP and implication of cAMP.J NeuroimmunolIn animals1995
Effect of long-acting antagonists of growth hormone (GH)-releasing hormone on GH and cyclic adenosine 3',5'-monophosphate release in superfused rat pituitary cells.EndocrinologyIn animals1995
The involvement of dipeptidyl peptidase IV in brush-border degradation of GRF(1-29)NH2 by intestinal mucosal cells.J Pharm PharmacolIn animals1995
Effects of acute administration of growth hormone-releasing hormone (GHRH) and oxytocin on somatotroph cells in sheep: morphometric study and growth hormone (GH) secretion.J Endocrinol InvestIn animals1995
Interaction between adrenergic and peptide stimulation in the rat pineal: pituitary adenylate cyclase-activating peptide.J NeurochemIn animals1995
The effect of GHRH on TSH release in rats in vivo and in vitro.J Endocrinol InvestIn animals1995
Inhibitory effect of vasoactive intestinal peptide (VIP) on phagocytosis in mouse peritoneal macrophages.Regul PeptIn animals1994
Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist.NeuropeptidesIn animals1994
Subcellular distribution of proteolytic activities degrading bioactive peptides and analogues in the rat small intestinal and colonic enterocytes.J Pharm PharmacolIn animals1994
Early increase in pulsatile growth hormone release after unilateral nephrectomy in adult rats.Am J PhysiolIn animals1994
Effects in vitro of new growth hormone releasing peptide (GHRP-1) on growth hormone secretion from ovine pituitary cells in primary culture.J NeuroendocrinolIn animals1994
The effect of GH-releasing peptide-2 (GHRP-2 or KP 102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist.J EndocrinolIn animals1994
Effect of somatotropin and/or equine chorionic gonadotropin on serum and follicular insulin-like growth factor I and insulin-like growth factor binding proteins in cattle.Biol ReprodIn animals1994
Lack of evidence for acute effects of growth hormone-releasing hormone on serum insulin and glucose levels in normal and hypophysectomized rats.Horm ResIn animals1994
Feedlot performance, carcass characteristics, hormones, and metabolites in steers actively immunized against growth hormone-releasing factor.J Anim SciIn animals1993
Effects of growth hormone-releasing factor and(or) thyrotropin-releasing hormone on growth, feed efficiency, carcass characteristics, and blood hormones and metabolites in beef heifers.J Anim SciIn animals1993
Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal.J Pineal ResIn animals1993
A new target for growth hormone releasing-hormone action in rat: the Sertoli cell.EndocrinologyIn animals1993
The entire vasoactive intestinal polypeptide molecule is required for the activation of the vasoactive intestinal polypeptide receptor: functional and binding studies on opossum internal anal sphincter smooth muscle.J Pharmacol Exp TherIn animals1993
Interaction of ovine pituitary adenylate cyclase-activating peptide (PACAP-38) with rat lung membranes.PeptidesIn animals1993
Comparison of the insulinotropic activity of glucagon-superfamily peptides in rat pancreas perfusion.Horm Metab ResIn animals1992
Lactation performance of sows injected with growth hormone-releasing factor during gestation and(or) lactation.J Anim SciIn animals1992
Catabolism of rat growth hormone-releasing factor(1-29) amide in rat serum and liver.PeptidesIn animals1992
Effect of iontophoresis on in vitro skin permeation of an analogue of growth hormone releasing factor in the hairless guinea pig model.J Pharm SciIn animals1992
Evaluation of the biological potency of new agmatine analogs of growth hormone-releasing hormone in the bovine.Proc Soc Exp Biol MedIn animals1992
Effect of prepartum administration of growth hormone-releasing factor on somatotropin, insulin-like growth factor I, milk production, and postpartum return to ovarian activity in primiparous beef heifers.J Anim SciIn animals1992
Role of selected endogenous peptides in growth hormone-releasing hexapeptide activity: analysis of growth hormone-releasing hormone, thyroid hormone-releasing hormone, and gonadotropin-releasing hormone.EndocrinologyIn animals1992
Effect of active immunization against growth hormone releasing factor on concentrations of somatotropin and insulin-like growth factor I in lactating beef cows.Domest Anim EndocrinolIn animals1992
Time-dependent reduction and potentiation of growth hormone (GH) responsiveness to GH-releasing factor induced by exogenous GH: role for somatostatin.EndocrinologyIn animals1992
Advances in the detection of growth hormone releasing hormone synthetic analogs.Drug Test AnalIn a lab dish2021
The use of pigs as an animal model to evaluate the efficacy, potency and specificity of two growth hormone releasing factor analogues.Growth Horm IGF ResIn a lab dish2001
Antagonistic analogs of growth hormone releasing hormone (GHRH) inhibit cyclic AMP production of human cancer cell lines in vitro.PeptidesIn a lab dish1999
Effects of peptide T derivatives on the proliferation of cultured human keratinocytes.ArzneimittelforschungIn a lab dish1995
Characterization of growth hormone-releasing hormone (GHRH) binding to cloned porcine GHRH receptor.PeptidesIn a lab dish1995
VIP antagonists enhance excitatory cholinergic neurotransmission in the human airway.LungIn a lab dish1994
Effects of vasoactive intestinal polypeptide antagonists on cholinergic neurotransmission in dog and cat trachea.Br J PharmacolIn a lab dish1991
VIP-ergic and cholinergic innervations in internal carotid arteries of the cat and rat.J Cardiovasc PharmacolIn a lab dish1991
A comparison of the biological activities of authentic rat GRF(1-43)OH with the analogue rat GRF(1-29)NH2.Can J Physiol PharmacolIn a lab dish1991
Analogues of growth hormone-releasing factor (1-29) amide containing the reduced peptide bond isostere in the N-terminal region.J Med ChemIn a lab dish1990
A glucagon-secretin-like peptide stimulates the intrinsic nervous plexus of guinea pig gallbladder.ExperientiaIn a lab dish1990
Secretory actions of vasoactive intestinal polypeptide, peptide histidine isoleucine and helodermin in rat small intestine: the effects of putative VIP antagonists upon VIP-induced ion secretion.Regul PeptIn a lab dish1989
Analogues of vasoactive intestinal peptide (VIP) contract the guinea-pig uterine artery but do not antagonize VIP-induced relaxations.Eur J PharmacolIn a lab dish1989
The effects of vasoactive intestinal peptide (VIP) antagonists, and VIP and peptide histidine isoleucine antisera on non-adrenergic, non-cholinergic relaxations of tracheal smooth muscle.Br J PharmacolIn a lab dish1989
The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways.PeptidesIn a lab dish1988
The synthetic peptide GRF (1-29)-NH2 with growth hormone releasing activity penetrates human epidermis in nitro.Acta Pharm SuecIn a lab dish1988
Differential effects of N-terminal modifications on the biological potencies of growth hormone releasing factor analogues with varying chain lengths.J Med ChemIn a lab dish1987
Specific labelling of high-affinity vasoactive intestinal peptide receptors in rat liver membranes by a growth hormone-releasing factor analog.NeuroendocrinologyIn a lab dish1986
Comparative structural requirements of thirty GRF analogs for interaction with GRF- and VIP receptors and coupling to adenylate cyclase in rat adenopituitary, liver and pancreas.PeptidesIn a lab dish1986
Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist.EndocrinologyIn a lab dish1985
Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.J Pharm Biomed AnalOther paper2026
Universal peptide synthesis via solid-phase methods fused with chemputation.Nat CommunOther paper2025
Chromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control urine samples.J Mass SpectromOther paper2024
Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.Anal BiochemOther paper2023
In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.Biomed ChromatogrOther paper2023
Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis.ElectrophoresisOther paper2023
Probing for peptidic drugs (2-10 kDa) in doping control blood samples.Anal Sci AdvOther paper2022
An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS.J Pharm Biomed AnalOther paper2022
A potentially effective drug for patients with recurrent glioma: sermorelin.Ann Transl MedOther paper2021
Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.J Chromatogr AOther paper2020
Exploring the Conformational Space of Growth-Hormone-Releasing Hormone Analogues Using Dopant Assisted Trapped Ion Mobility Spectrometry-Mass Spectrometry.J Phys Chem BOther paper2019
Glycine-modified growth hormone secretagogues identified in seized doping material.Drug Test AnalOther paper2019
Structural Motif Descriptors as a Way To Elucidate the Agonistic or Antagonistic Activity of Growth Hormone-Releasing Hormone Peptide Analogues.ACS OmegaOther paper2018
Growth hormone-releasing hormone (GHRH) and its agonists inhibit hepatic and tumoral secretion of IGF-1.OncotargetOther paper2018
Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.Am J Mens HealthOther paper2017
Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth.PeptidesOther paper2017
Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.Anal Bioanal ChemOther paper2016
Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe.Drug Test AnalOther paper2016
Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS.Drug Test AnalOther paper2015
The GHRH + arginine stimulated pituitary GH secretion in children and adults with Prader-Willi syndrome shows age- and BMI-dependent and genotype-related differences.Growth Horm IGF ResOther paper2013
Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency.J Clin Endocrinol MetabOther paper2013
Growth hormone-releasing hormone receptor splice variant 1 is frequently expressed in oral squamous cell carcinomas.Horm CancerOther paper2012
GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells.Cell CycleOther paper2011
Activation of mitogen-activated protein kinases by a splice variant of GHRH receptor.J Mol EndocrinolOther paper2010
Repetitive stimulation of the pituitary with growth-hormone-releasing hormone alters the proportion of 22 and 20 kilodalton human-growth hormone released.Int J Pediatr EndocrinolOther paper2010
Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro.NeuropeptidesOther paper2009
Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist.Oncol RepOther paper2008
Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines.Br J CancerOther paper2008
Lipopeptide antagonists of growth hormone-releasing hormone with improved antitumor activities.Proc Natl Acad Sci U S AOther paper2006
Antagonist of growth hormone-releasing hormone induces apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway.Proc Natl Acad Sci U S AOther paper2005
Chromatographic separation and mass spectrometric identification of positional isomers of polyethylene glycol-modified growth hormone-releasing factor (1-29).J Chromatogr AOther paper2004
Pharmacodynamic evaluation of a PEGylated analogue of human growth hormone releasing factor in rats and pigs.Growth Horm IGF ResOther paper2004
Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes.J EndocrinolOther paper2002
The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas.Proc Natl Acad Sci U S AOther paper2002
[Effect of transdermal administration of 17-beta estradiol on the release of growth hormone by growth hormone liberating hormone (GH-RH-1-29) in climacteric women before and after treatment].Ginecol Obstet MexOther paper2001
Contribution of growth hormone-releasing hormone and somatostatin to decreased growth hormone secretion in elderly men.S Afr Med JOther paper2001
Growth during and after a trial of growth hormone releasing hormone 1-29 in children with idiopathic short stature or growth hormone neurosecretory dysfunction.J Pediatr Endocrinol MetabOther paper2000
Interaction of the novel GH secretagogue hexarelin with GHRH in regulating the secretion of GH by cultured human pituitary somatotrophinomas in vitro.J Tongji Med UnivOther paper2000
Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma.Proc Natl Acad Sci U S AOther paper1999
In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans: evidence for relative GHRH deficiency in aging.J Clin Endocrinol MetabOther paper1999
Predicting bull growth performance and carcass composition from growth hormone response to growth hormone-releasing hormone.J Anim SciOther paper1999
Effects of active immunization against growth-hormone releasing factor on puberty and reproductive development in gilts.J Anim SciOther paper1999
Functional characterization of a receptor for vasoactive-intestinal-peptide-related peptides in cultured dermal melanophores from Xenopus laevis.Pigment Cell ResOther paper1999
Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers.J Clin Endocrinol MetabOther paper1999
The growth hormone response to hexarelin in patients with Prader-Willi syndrome.J Endocrinol InvestOther paper1998
Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells.EndocrineOther paper1998
Presence of GHRH mRNA in human pituitary somatotrophinomas and its relationship to in vitro effect of a GHRH-antagonist on GH secretion and cAMP production.PituitaryOther paper1998
Human growth hormone-releasing hormone hGHRH(1-29)-NH2: systematic structure-activity relationship studies.J Med ChemOther paper1998
New analogs of human growth hormone-releasing hormone (1-29) with high and prolonged antagonistic activity.J Pept ResOther paper1998
Treatment of radiation-induced growth hormone deficiency with growth hormone-releasing hormone.Clin Endocrinol (Oxf)Other paper1997
Inhibitory effects of galanin on growth hormone (GH) release in cultured GH-secreting adenoma cells: comparative study with octreotide, GH-releasing hormone, and thyrotropin-releasing hormone.MetabolismOther paper1997
Glutamate decarboxylase autoimmunity and growth hormone secretion in type I diabetes mellitus.MetabolismOther paper1997
Presence of a bioactive and immunoreactive growth-hormone-releasing-factor-like substance in porcine placenta.Biol NeonateOther paper1997
Nocturnal growth hormone (GH) secretion is eliminated by infusion of GH-releasing hormone antagonist.J Clin Endocrinol MetabOther paper1996
Growth hormone response to growth hormone-releasing hormone varies with the hypothalamic-pituitary abnormalities.Eur J EndocrinolOther paper1996
Evaluation of growth hormone (GH) responses to pulsed GH-releasing hormone administration using the MTT-ESTA bioassay.Eur J EndocrinolOther paper1996
Hypothalamic control of growth hormone (GH) secretion in type I diabetic men: effect of the combined administration of GH-releasing hormone and hexarelin, a novel GHRP-6 analog.Endocr ResOther paper1996
Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.Eur J PharmacolOther paper1996

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Registered studies in people (15)

StudiesStageStatusPeople taking partUpdated
Adult Growth Hormone Deficiency and Cardiovascular RiskStage 4Stopped early72022-11-16
TH9507 Extension Study in Patients With HIV-Associated LipodystrophyStage 3Finished2632022-09-30
The Effect of Growth Hormone Releasing Hormone on Cognitive Function in Individuals With Mild Cognitive ImpairmentStage 1Finished222019-11-04
The Effect of GHRH Therapy on Myocardial Structure and Function in Congestive Heart FailureStage 2Finished32019-07-09
Three Month Treatment of Growth Hormone Releasing Hormone (GHRH) in the ElderlyStage 2Stopped early132019-05-24
Effectiveness of Growth Hormone Releasing Hormone in Reducing Abdominal Fat in People Who Are ObeseStage 2Finished602017-12-13
Study of Intranasal Octreotide (DP1038) in Healthy Adult VolunteersStage 1Finished322017-05-12
Six Month Treatment of Growth Hormone Releasing Hormone (GHRH) in the ElderlyStage 2Stopped early52017-04-27
Diagnosing Adult Growth Hormone Deficiency–Finished1602017-01-12
Estradiol-Receptor Blockade in Older Men and WomenStage 1Finished402016-09-14
Growth Hormone Releasing Hormone (GHRH) Treatment for Age-Related Sleep Disturbances–Finished–2015-12-03
Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone DeficiencyStage 3Finished692014-08-05
SMART: Somatotrophics, Memory, and Aging Research TrialStage 2Finished1512013-12-19
VRS-317 in Adult Subjects With Growth Hormone DeficiencyStage 1Finished502012-07-23
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing–Finished902010-03-05