Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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RAD-140

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Prace naukowe

BadaniaRodzaj badaniaRok
A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer.Clin Breast CancerBez losowania grup2022
Spontaneous Splenic Rupture in a Patient With Recent Use of Performance-Enhancing Compounds: A Case Report and Literature Review.CureusOpisy przypadków2026
Cholestatic Drug-Induced Liver Injury From Rad-140 Successfully Treated With Corticosteroids.ACG Case Rep JOpisy przypadków2025
Selective Androgen Receptor Modulators Leading to Liver Injury: A Case Report.CureusOpisy przypadków2024
Reversible Gynecomastia and Hypogonadism Due to Usage of Commercial Performance-Enhancing Supplement Use.JCEM Case RepOpisy przypadków2024
Selective androgen receptor modulator abuse-induced heart failure: catastrophic effects of RAD-140 (Testolone).Pol Arch Intern MedOpisy przypadków2024
Myopericarditis Following Use of Selective Androgen Receptor Modifier "RAD-140".JACC Case RepOpisy przypadków2024
Severe liver injury following use of RAD-140, a selective androgen receptor modulator, for body building.Aust PrescrOpisy przypadków2024
Idiosyncratic drug-induced liver injury related to use of novel selective androgen receptor modulator RAD140 (Testalone): a case report.J Med Case RepOpisy przypadków2023
Selective Androgen Receptor Modulators (SARMs)-Induced Liver Injury: A Case Report and Review of Literature.CureusOpisy przypadków2023
Acute Myocarditis From the Use of Selective Androgen Receptor Modulator (SARM) RAD-140 (Testolone).CureusOpisy przypadków2022
Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033).ACG Case Rep JOpisy przypadków2020
Detection of SARMs in doping control analysis.Mol Cell EndocrinolPrzegląd badań2018
Treatment with a selective androgen receptor modulator (RAD140) is linked to better cardiac function, with male-specific effects that are graded by interleukin-6.GeroscienceNa zwierzętach2026
The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice.Mech Ageing DevNa zwierzętach2025
Detection of nonsteroidal and steroidal selective androgen receptor modulators in equine hair after oral administrations.Drug Test AnalNa zwierzętach2025
Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes.Drug Test AnalNa zwierzętach2022
Label-free proteomics for discovering biomarker candidates of RAD140 administration to castrated horses.Drug Test AnalNa zwierzętach2021
Metabolic studies of selective androgen receptor modulators RAD140 and S-23 in horses.Drug Test AnalNa zwierzętach2021
Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood.Drug Test AnalNa zwierzętach2020
Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.EndocrinologyNa zwierzętach2014
Unregulated gains: a case of RAD-140-induced liver injury.Proc (Bayl Univ Med Cent)Inna praca2026
Initial testing procedure based on microextraction followed by LC-HRMS analysis to determine 107 xenobiotics and their metabolites in serum/plasma.AnalystInna praca2026
Exploring transdermal SARMs exposure: analysis of the elimination profiles and metabolism for doping control purposes.J Anal ToxicolInna praca2025
Rapid detection of illegal selective androgen receptor modulators in unregistered supplements using a combination of selected solid-state analytical methods.ADMET DMPKInna praca2025
Deep Learning-Based Drug Compounds Discovery for Gynecomastia.BiomedicinesInna praca2025
Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport.Drug Test AnalInna praca2024
Social Interest Data as a Proxy for Off-Label Performance-Enhancing Drug Use: Implications and Clinical Considerations.CureusInna praca2024
A rapid synthesis of molecularly imprinted polymer nanoparticles for the extraction of performance enhancing drugs (PIEDs).Nanoscale AdvInna praca2023
Comparison of in vitro approaches for predicting the metabolism of the selective androgen receptor modulator RAD140.Anal Bioanal ChemInna praca2023
Pharmacological Targeting of Androgen Receptor Elicits Context-Specific Effects in Estrogen Receptor-Positive Breast Cancer.Cancer ResInna praca2023
Detection of selective androgen receptor modulators (SARMs) in serum using a molecularly imprinted nanoparticle surface plasmon resonance sensor.J Mater Chem BInna praca2022
Human In Vivo Metabolism and Elimination Behavior of Micro-Dosed Selective Androgen Receptor Modulator RAD140 for Doping Control Purposes.MetabolitesInna praca2022
Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patients.Genome BiolInna praca2022
The forensic response after an adverse analytical finding (doping) involving a selective androgen receptor modulator (SARM) in human athlete.J Pharm Biomed AnalInna praca2022
Simultaneous detection of different chemical classes of selective androgen receptor modulators in urine by liquid chromatography-mass spectrometry-based techniques.J Pharm Biomed AnalInna praca2021
Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay.J Steroid Biochem Mol BiolInna praca2019
Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action.Clin Cancer ResInna praca2017
Expanding sports drug testing assays: mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP-105.Rapid Commun Mass SpectromInna praca2013
Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.ACS Med Chem LettInna praca2011

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Zarejestrowane badania na ludziach (1)

BadaniaEtapStatusLiczba uczestnikówAktualizacja
Phase 1, First-in-Human Study of RAD140 in Postmenopausal Women With Breast CancerEtap 1Zakończone202022-08-18