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Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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IGF-1 LR3

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Prace naukowe

BadaniaRodzaj badaniaRok
Insulin-like growth factor I receptor expression and function in fibroblasts from two patients with deletion of the distal long arm of chromosome 15.J Clin Endocrinol MetabOpisy przypadków1995
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Front Endocrinol (Lausanne)Przegląd badań2026
The role of insulin-like growth factors in small intestinal cell growth and development.Horm Metab ResPrzegląd badań1999
Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.Int J Biol MacromolNa zwierzętach2025
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.J Dev Orig Health DisNa zwierzętach2023
N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.Int J Mol SciNa zwierzętach2022
Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.Am J Physiol Endocrinol MetabNa zwierzętach2021
IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.Am J Physiol Endocrinol MetabNa zwierzętach2021
Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.FASEB JNa zwierzętach2020
Inhibition of activin-like kinase 4/5 attenuates cancer cachexia associated muscle wasting.Sci RepNa zwierzętach2019
Epidermal growth factor receptor is required for estradiol-stimulated bovine satellite cell proliferation.Domest Anim EndocrinolNa zwierzętach2014
Na+ transport across rumen epithelium of hay-fed sheep is acutely stimulated by the peptide IGF-1 in vitro.Exp PhysiolNa zwierzętach2012
Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression.J EndocrinolNa zwierzętach2008
Localization of insulin-like growth factor (IGFBP)-3 in cultured porcine embryonic myogenic cells before and after TGF-beta1 treatment.Domest Anim EndocrinolNa zwierzętach2007
Leptin in the bovine corpus luteum: receptor expression and effects on progesterone production.Mol Reprod DevNa zwierzętach2007
Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis.OncogeneNa zwierzętach2007
Effect of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells.Domest Anim EndocrinolNa zwierzętach2006
The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo.EndocrinologyNa zwierzętach2005
Production of recombinant porcine IGF-binding protein-5 and its effect on proliferation of porcine embryonic myoblast cultures in the presence and absence of IGF-I and Long-R3-IGF-I.J EndocrinolNa zwierzętach2005
Effect of recombinant porcine IGFBP-3 on IGF-I and long-R3-IGF-I-stimulated proliferation and differentiation of L6 myogenic cells.J Cell PhysiolNa zwierzętach2004
Regulation of insulin-like growth factor (IGF)-binding protein expression by growth factors and cytokines alters IGF-mediated proliferation of postnatal lung fibroblasts.Exp Lung ResNa zwierzętach2004
Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes.Am J Physiol Regul Integr Comp PhysiolNa zwierzętach2003
Interaction of bovine granulosa and theca cells in a novel serum-free co-culture system.ReproductionNa zwierzętach2003
Paracrine effects of oocyte secreted factors and stem cell factor on porcine granulosa and theca cells in vitro.Reprod Biol EndocrinolNa zwierzętach2003
Oocyte-mediated suppression of follicle-stimulating hormone- and insulin-like growth factor-induced secretion of steroids and inhibin-related proteins by bovine granulosa cells in vitro: possible role of transforming growth factor alpha.Biol ReprodNa zwierzętach2003
Effect of recombinant porcine IGF-binding protein-3 on proliferation of embryonic porcine myogenic cell cultures in the presence and absence of IGF-I.J EndocrinolNa zwierzętach2003
Insulin-like growth factor-I and analogues increase growth in artificially-reared neonatal pigs.Br J NutrNa zwierzętach2002
Effects of insulin-like growth factor-I and its analogue, long-R3-IGF-I, on intestinal absorption of 3-O-methyl-D-glucose are less pronounced than gut mucosal growth responses.Growth FactorsNa zwierzętach2002
Steroidogenesis in bovine granulosa cells: the effect of short-term changes in dietary intake.ReproductionNa zwierzętach2002
Modulatory effects of gonadotrophins and insulin-like growth factor on the secretion of inhibin A and progesterone by granulosa cells from chicken preovulatory (F1-F3) follicles.ReproductionNa zwierzętach2002
Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells.Spine (Phila Pa 1976)Na zwierzętach2001
Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells.Biochem Biophys Res CommunNa zwierzętach2001
Interactions between follicle-stimulating hormone and growth factors in modulating secretion of steroids and inhibin-related peptides by nonluteinized bovine granulosa cells.Biol ReprodNa zwierzętach2001
Granulosa cells of the cumulus oophorus are different from mural granulosa cells in their response to gonadotrophins and IGF-I.J EndocrinolNa zwierzętach2001
Production of tissue inhibitors of metalloproteinases (TIMPs) by pig ovarian cells in vivo and the effect of TIMP-1 on steroidogenesis in vitro.J Reprod FertilNa zwierzętach2000
Intramammary infusion of insulin or long R3 insulin-like growth factor-I did not increase milk protein yield in dairy cows.J Dairy SciNa zwierzętach2000
Differential regulation of IGF-binding proteins in rabbit costal chondrocytes by IGF-I and dexamethasone.J EndocrinolNa zwierzętach2000
Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I.Exp PhysiolNa zwierzętach2000
Differential regulation of pig theca cell steroidogenesis by LH, insulin-like growth factor I and granulosa cells in serum-free culture.J Reprod FertilNa zwierzętach2000
Novel studies on influence of gonadotropins and insulin-like growth factor-I on growth of cumulus oophorus in the rat.EndocrineNa zwierzętach2000
Action of long(R3)-insulin-like growth factor-1 on protein metabolism in beef heifers.Domest Anim EndocrinolNa zwierzętach1999
Cellular localization and expression of insulin-like growth factors (IGFs) and IGF binding proteins within the epiphyseal growth plate of the ovine fetus: possible functional implications.Can J Physiol PharmacolNa zwierzętach1999
Maintenance of oestradiol production and expression of cytochrome P450 aromatase enzyme mRNA in long-term serum-free cultures of pig granulosa cells.J Reprod FertilNa zwierzętach1999
Rat milk and dietary long arginine3 insulin-like growth factor I promote intestinal growth of newborn rat pups.Pediatr ResNa zwierzętach1998
Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse.J Biol ChemNa zwierzętach1998
Small intestinal morphology in eight-day-old calves fed colostrum for different durations or only milk replacer and treated with long-R3-insulin-like growth factor I and growth hormone.J Anim SciNa zwierzętach1998
Effects of dose of LH on androgen production and luteinization of ovine theca cells cultured in a serum-free system.J Reprod FertilNa zwierzętach1998
Endocrine and metabolic changes in neonatal calves in response to growth hormone and long-R3-insulin-like growth factor-I administration.Biol NeonateNa zwierzętach1998
Long [R3] insulin-like growth factor-I reduces growth, plasma growth hormone, IGF binding protein-3 and endogenous IGF-I concentrations in pigs.J EndocrinolNa zwierzętach1997
Interactions between follicle-stimulating hormone and growth factors in regulation of deoxyribonucleic acid synthesis in bovine granulosa cells.Biol ReprodNa zwierzętach1997
The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I.Am J PhysiolNa zwierzętach1997
Effects of insulin and insulin-like growth factors on proliferation of rat ovarian theca-interstitial cells.Biol ReprodNa zwierzętach1997
Thyrotropin via cyclic AMP induces insulin receptor expression and insulin Co-stimulation of growth and amplifies insulin and insulin-like growth factor signaling pathways in dog thyroid epithelial cells.J Biol ChemNa zwierzętach1996
Inhibition of cellular proliferation and modulation of insulin-like growth factor binding proteins by retinoids in a bovine mammary epithelial cell line.J Cell PhysiolNa zwierzętach1996
Design and characterisation of long-R3-insulin-like growth factor-I muteins which show resistance to pepsin digestion.Growth FactorsNa zwierzętach1996
Administration of insulin-like growth factor-I (IGF-I) peptides for three days stimulates proliferation of the small intestinal epithelium in rats.GutNa zwierzętach1995
Insulin-like growth factor binding proteins-2 and -3 stimulate growth hormone receptor binding and mitogenesis in rat osteosarcoma cells.EndocrinologyNa zwierzętach1995
Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig.J EndocrinolNa zwierzętach1995
Effects of insulin and insulin-like growth factors on protein and energy metabolism in tumour-bearing rats.Biochem JNa zwierzętach1994
Differential steroidogenic response of subpopulations of porcine granulosa cells to insulin-like growth factor-1 (IGF-1) or IGF-1 analogs.Biol ReprodNa zwierzętach1994
Several insulin-like growth factor-I analogues and complexes of insulin-like growth factors-I and -II with insulin-like growth factor-binding protein-3 fail to mimic the effect of growth hormone upon lactation in the rat.J EndocrinolNa zwierzętach1994
Effects of IGF-I bioavailability on bovine preantral follicular development in vitro.ReproductionW probówce2007
The effect of insulin-like growth factor analogs on turkey satellite cell and embryonic myoblast proliferation.Poult SciW probówce2001
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.J Alzheimers DisInna praca2025
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.Appl Microbiol BiotechnolInna praca2023
Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep.Front PhysiolInna praca2022
IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype.Am J PatholInna praca2011
Detection of His-tagged Long-R³-IGF-I in a black market product.Growth Horm IGF ResInna praca2010
Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity.J Biol ChemInna praca2009
Novel insulin-like growth factor-methotrexate covalent conjugate inhibits tumor growth in vivo at lower dosage than methotrexate alone.Transl ResInna praca2009
NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation.Cancer ResInna praca2009
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.Cancer ResInna praca2006
Insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5 mediate TGF-beta- and myostatin-induced suppression of proliferation in porcine embryonic myogenic cell cultures.Exp Cell ResInna praca2005
Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells.J Clin Endocrinol MetabInna praca2003
Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.Biochem Biophys Res CommunInna praca2002
Insulin-like growth factor binding protein-2 mediates the inhibition of DNA synthesis by transforming growth factor-beta in mink lung epithelial cells.J Cell PhysiolInna praca2002
Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling.Growth Horm IGF ResInna praca2001
Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling.Circ ResInna praca2001
Insulin-like growth factor binding protein-3 is secreted as a phosphoprotein by human breast cancer cells.Mol Cell EndocrinolInna praca1999
Clearance of IGFs and insulin from wounds: effect of IGF-binding protein interactions.Am J PhysiolInna praca1999
Chemical treatment of Escherichia coli: 3. Selective extraction of a recombinant protein from cytoplasmic inclusion bodies in intact cells.Biotechnol BioengInna praca1999
Involvement of insulin-like growth factor-1 and its binding proteins in proliferation and differentiation of murine bone marrow-derived macrophage precursors.EndocrineInna praca1998
Effect of follicle stimulating hormone and insulin-like growth factors on proteolysis of insulin-like growth factor binding protein-4 in human granulosa cells.Mol Hum ReprodInna praca1998
Chemical treatment of Escherichia coli. II. Direct extraction of recombinant protein from cytoplasmic inclusion bodies in intact cells.Biotechnol BioengInna praca1998
Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells.Biochem Biophys Res CommunInna praca1997
Proteolysis of insulin-like growth factor-binding protein-3 by human skin keratinocytes in culture in comparison to that in skin interstitial fluid: the role and regulation of components of the plasmin system.J Clin Endocrinol MetabInna praca1997
Antiproliferative action of vitamin D-related compounds and insulin-like growth factor-binding protein 5 accumulation.J Natl Cancer InstInna praca1997
Inhibition of insulin- and insulin-like growth factor-I-stimulated growth of human breast cancer cells by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogue EB1089.Eur J CancerInna praca1996
Regulation of insulin-like growth factor-binding protein-4 in human endometrial stromal cell cultures: evidence for ligand-induced proteolysis.J Clin Endocrinol MetabInna praca1995
Proteolytic degradation of insulin-like growth factor (IGF)-binding protein-3 by porcine ovarian granulosa cells in culture: regulation by IGF-I.EndocrinologyInna praca1994
Cytokines modulate the sensitivity of human fibroblasts to stimulation with insulin-like growth factor-I (IGF-I) by altering endogenous IGF-binding protein production.J EndocrinolInna praca1993

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