Graded
The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
PL

Fat loss

Approved obesity medicines exist, prescribed by a doctor. Versions sold online are a different product with unknown contents.

First, legal options with stronger studies

  • Eating a little less than you burn, with enough protein.
  • Strength training to protect muscle.
  • Medical care for obesity, including approved medicines when needed.

What studies found for specific substances

Sorted alphabetically. Order does not imply a recommendation.

  • D5-amino-1MQ

    Weight and fat fell in obese mice. There are three papers and no study in people.

  • DAOD-9604

    Obese rats gained less weight. There are no studies with random groups in people.

  • BCagrilintide

    Weight fell 6.0% to 10.8%, and 3.0% on placebo, in an early study. In a large study the mix with semaglutide reached 20.4% against 3.0%, but that is a result for the mix.

  • CCardarine

    In a 2-week study with random groups of 6 people each, liver fat fell by 20%. Nobody measured body fat or weight loss. Work on it as a medicine stopped after cancer findings in mice.

  • AhCG

    In blinded studies from 1976 to 1990, people lost no more weight on hCG than on placebo injections with the same diet. A 1995 pooled analysis found no scientific proof that it works for obesity.

  • CL-carnitine

    Results differ. One study found no change in overweight women, while pooled analyses report a small loss, about 1.33 kg in one. These are studies of supplements, not injections.

  • BOxytocin

    In the largest study, 61 adults with obesity over 8 weeks, weight and body fat did not change more than on placebo. Two smaller studies in special groups found no weight loss either.

  • ARetatrutide

    Early and large studies show big weight loss: 18.8% at the highest dose and 5.1% on placebo, in adults with diabetes. No medicine is approved yet, and this grade says nothing about products sold online.

  • ASemaglutide

    Weight fell by 14.9% on average, and by 2.4% on placebo, after 68 weeks. Two more large studies agree. The maker paid for the studies, which tested the pharmacy medicine.

  • BTesamorelin

    Fat around the organs in the belly fell about 18% in people with HIV, the approved use. The effect faded after stopping. There are no data on ordinary weight loss.

  • ATirzepatide

    Weight fell by 20.9% on average at the highest dose studied, and by 3.1% on placebo, after 72 weeks. In people with diabetes it fell 12.8% to 14.7%, and 3.2% on placebo. Weight came back after stopping. The maker paid for the studies, which tested the pharmacy medicine.