Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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KPV

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Prace naukowe

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Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.Drug Discov TodayPrzegląd badań2025
The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials.CellsPrzegląd badań2023
Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore.Adv Exp Med BiolPrzegląd badań2010
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.Endocr RevPrzegląd badań2008
New insights into the functions of alpha-MSH and related peptides in the immune system.Ann N Y Acad SciPrzegląd badań2003
The neuropeptide alpha-MSH in host defense.Ann N Y Acad SciPrzegląd badań2000
The neuroimmunomodulatory peptide alpha-MSH.Ann N Y Acad SciPrzegląd badań2000
Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers.ACS Appl Mater InterfacesNa zwierzętach2024
Skin-adaptive film dressing with smart-release of growth factors accelerated diabetic wound healing.Int J Biol MacromolNa zwierzętach2022
Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats.ACS Biomater Sci EngNa zwierzętach2021
A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis.Biomater SciNa zwierzętach2019
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.Inflamm Bowel DisNa zwierzętach2008
Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide.Exp Eye ResNa zwierzętach2006
Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions.J Surg ResNa zwierzętach2006
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.J Pharmacol Exp TherNa zwierzętach2003
Downregulation of glucocorticoid receptors of liver cytosols and the role of the inflammatory cytokines in pathological stress in scalded rats.BurnsNa zwierzętach2002
Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats.Crit Care MedNa zwierzętach2002
[Changes in aldosterone binding activity of kidney cytosol after stress in rats and the regulation].Sheng Li Xue BaoNa zwierzętach2001
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.GastroenterologyW probówce2008
Lysine-Proline-Valine attenuates oxidized low-density lipoprotein-induced foam cell formation and inflammatory responses in RAW264.7 macrophages.Tissue CellInna praca2026
KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling.Tissue CellInna praca2026
Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells.CytotechnologyInna praca2026
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.Sci AdvInna praca2026
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.Tissue CellInna praca2025
KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.Adv Healthc MaterInna praca2024
PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS.Front PharmacolInna praca2024
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.Bioact MaterInna praca2024
In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis.Biomater SciInna praca2021
Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes.Eur J PharmacolInna praca2020
Are melanocortin peptides future therapeutics for cutaneous wound healing?Exp DermatolInna praca2019
Structural modification of the tripeptide KPV by reductive "glycoalkylation" of the lysine residue.PLoS OneInna praca2018
Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.Mol TherInna praca2017
Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin.J Pharm SciInna praca2017
Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis.ACS Appl Mater InterfacesInna praca2017
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.Cell Mol Gastroenterol HepatolInna praca2016
Stability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenates.Biomed ChromatogrInna praca2015
Modulation of basophil activity: a novel function of the neuropeptide α-melanocyte-stimulating hormone.J Allergy Clin ImmunolInna praca2012
Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists.Int J Physiol Pathophysiol PharmacolInna praca2012
Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.GastroenterologyInna praca2010
alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.Ann Rheum DisInna praca2007
Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.PeptidesInna praca2006
Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2.J Pept ResInna praca2005
alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.J Invest DermatolInna praca2004
Alpha-melanocyte-stimulating hormone peptides inhibit HIV-1 expression in chronically infected promonocytic U1 cells and in acutely infected monocytes.J Leukoc BiolInna praca2000
Antimicrobial effects of alpha-MSH peptides.J Leukoc BiolInna praca2000

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