Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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AICAR

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Effects of acadesine on myocardial infarction, stroke, and death following surgery. A meta-analysis of the 5 international randomized trials. The Multicenter Study of Perioperative Ischemia (McSPI) Research Group.JAMAAnaliza zbiorcza1997
Circulating levels of MOTS-c in patients with breast cancer treated with metformin.Aging (Albany NY)Z losowaniem grup2022
Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.Cell MetabZ losowaniem grup2016
Predictors of contemporary coronary artery bypass grafting outcomes.J Thorac Cardiovasc SurgZ losowaniem grup2014
LD-aminopterin in the canine homologue of human atopic dermatitis: a randomized, controlled trial reveals dosing factors affecting optimal therapy.PLoS OneZ losowaniem grup2014
Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial.JAMAZ losowaniem grup2012
Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle.Am J Physiol Endocrinol MetabZ losowaniem grup2011
Effects of acadesine on the incidence of myocardial infarction and adverse cardiac outcomes after coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.AnesthesiologyZ losowaniem grup1995
Acadesine: a new drug that may improve myocardial protection in coronary artery bypass grafting. Results of the first international multicenter study. Multinational Acadesine Study Group.J Thorac Cardiovasc SurgZ losowaniem grup1995
Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass.J Thorac Cardiovasc SurgZ losowaniem grup1995
Effect of acadesine, a new metabolic agent, on exercise-induced myocardial ischemia in chronic stable angina.Cardiovasc Drugs TherZ losowaniem grup1994
An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group.Anesth AnalgZ losowaniem grup1994
Allopurinol Treatment Improves Cognitive Skills, Adaptive Behavior, and Biochemical Markers in Young Patients With Adenylosuccinate Lyase Deficiency.J Inherit Metab DisBez losowania grup2025
Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation.Front ImmunolBez losowania grup2019
Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.Acta DiabetolBez losowania grup2018
Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation.J PhysiolBez losowania grup2016
AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle.Vet JBez losowania grup2015
Role of AMPK in UVB-induced DNA damage repair and growth control.OncogeneBez losowania grup2013
Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II study.Cancer Chemother PharmacolBez losowania grup2013
Skeletal muscle NAMPT is induced by exercise in humans.Am J Physiol Endocrinol MetabBez losowania grup2010
Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients.DiabetologiaBez losowania grup2008
13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man.Biochem Biophys Res CommunBez losowania grup2007
5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.DiabetesBez losowania grup2007
Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.DiabetologiaBez losowania grup2006
Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro.Am J Physiol Endocrinol MetabBez losowania grup2005
Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling.FASEB JBez losowania grup2004
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.Rheumatology (Oxford)Bez losowania grup1999
Effect of acadesine on myocardial ischaemia in patients with coronary artery disease.Eur J PharmacolBez losowania grup1997
Electrocardiographic and hemodynamic changes and their association with myocardial infarction during coronary artery bypass surgery. A multicenter study. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.AnesthesiologyBez losowania grup1997
Case report of a rare purine synthesis disorder due to 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICAR) deficiency.Brain DevOpisy przypadków2022
Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? - A Case Report.Pharmgenomics Pers MedOpisy przypadków2022
AICA-ribosiduria due to ATIC deficiency: Delineation of the phenotype with three novel cases, and long-term update on the first case.J Inherit Metab DisOpisy przypadków2020
Very mild isolated intellectual disability caused by adenylosuccinate lyase deficiency: a new phenotype.Mol Genet Metab RepOpisy przypadków2020
Broadening phenotype of adenylosuccinate lyase deficiency: A novel clinical pattern resembling neuronal ceroid lipofuscinosis.Mol Genet Metab RepOpisy przypadków2019
Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum.Mol Genet Metab RepOpisy przypadków2016
AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC.Am J Hum GenetOpisy przypadków2004
Treatment of Lesch-Nyhan syndrome with AICAR.Adv Exp Med BiolOpisy przypadków1994
The central role of macrophages in skeletal muscle regeneration: Phenotypic Polarization, metabolic reprogramming, and therapeutic prospects.Biochem PharmacolPrzegląd badań2026
AMPK as a central regulator of metabolic memory: mechanisms and therapeutic opportunities.J Diabetes Metab DisordPrzegląd badań2026
Targeting AMPK Networks for Male Reproductive Health: Mechanisms and Emerging Therapies.CellsPrzegląd badań2026
When is a sample a urine sample? Markers for urine sample authenticity assessment in sports drug testing.BioanalysisPrzegląd badań2025
Purine Nucleotide Precursors in Preventing Myocardial Ischemia-Reperfusion Injury.Int J Mol SciPrzegląd badań2025
Exploring Cirrhosis: Insights into Advances in Therapeutic Strategies.Int J Mol SciPrzegląd badań2025
Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.ChembiochemPrzegląd badań2025
The diagnosis and treatment of disorders of nucleic acid/nucleotide metabolism associated with epilepsy.Acta EpileptolPrzegląd badań2025
AMPK: The energy sensor at the crossroads of aging and cancer.Semin Cancer BiolPrzegląd badań2024
Targeting AMP-activated protein kinase in sepsis.Front Endocrinol (Lausanne)Przegląd badań2024
5'AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases.Crit Rev Food Sci NutrPrzegląd badań2024
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.J Transl MedPrzegląd badań2023
MOTS-c Functionally Prevents Metabolic Disorders.MetabolitesPrzegląd badań2023
Modulation of hypothalamic AMPK and hypothalamic neuropeptides in the control of eating behavior: A systematic review.Life SciPrzegląd badań2022
GDF15 in Appetite and Exercise: Essential Player or Coincidental Bystander?EndocrinologyPrzegląd badań2022
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.CellsPrzegląd badań2021
Autophagy in the physiological endometrium and cancer.AutophagyPrzegląd badań2021
Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation.Reprod Domest AnimPrzegląd badań2020
Autophagy modulation in animal models of corneal diseases: a systematic review.Mol Cell BiochemPrzegląd badań2020
Vascular adenosine monophosphate-activated protein kinase: Enhancer, brake or both?Basic Clin Pharmacol ToxicolPrzegląd badań2020
Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics.Int J Mol SciPrzegląd badań2020
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.Cardiovasc Drugs TherPrzegląd badań2020
[Advances on the anti-inflammatory and protective effect of AMPK activators].Sheng Li Xue BaoPrzegląd badań2019
In vitro experimental models for examining the skeletal muscle cell biology of exercise: the possibilities, challenges and future developments.Pflugers ArchPrzegląd badań2019
Targeting AMPK in Diabetes and Diabetic Complications: Energy Homeostasis, Autophagy and Mitochondrial Health.Curr Med ChemPrzegląd badań2019
The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia.Curr Med ChemPrzegląd badań2019
Modulation of the de novo purine nucleotide pathway as a therapeutic strategy in mitochondrial myopathy.Pharmacol ResPrzegląd badań2018
The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration.Int J Mol SciPrzegląd badań2018
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.Int J Mol SciPrzegląd badań2018
Interplay between adenylate metabolizing enzymes and AMP-activated protein kinase.FEBS JPrzegląd badań2018
Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?Pharmacol ResPrzegląd badań2018
Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls.Biochem PharmacolPrzegląd badań2018
Modulating Mitophagy in Mitochondrial Disease.Curr Med ChemPrzegląd badań2018
Exercise in a Pill: The Latest on Exercise-Mimetics.Brain PlastPrzegląd badań2017
Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells.Int Neurourol JPrzegląd badań2016
HGSD attenuates neuronal apoptosis through enhancing neuronal autophagy in the brain of diabetic mice: The role of AMP-activated protein kinase.Life SciPrzegląd badań2016
Caloric restriction and exercise "mimetics'': Ready for prime time?Pharmacol ResPrzegląd badań2016
Targeting autophagy and mitophagy for mitochondrial diseases treatment.Expert Opin Ther TargetsPrzegląd badań2016
Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis.Adv Exp Med BiolPrzegląd badań2016
Activation of AMPK and its Impact on Exercise Capacity.Sports MedPrzegląd badań2015
Folate-Dependent Purine Nucleotide Biosynthesis in Humans.Adv NutrPrzegląd badań2015
Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).J Physiol PharmacolPrzegląd badań2014
Perspectives of drug-based neuroprotection targeting mitochondria.Rev Neurol (Paris)Przegląd badań2014
Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models.Br J PharmacolPrzegląd badań2014
Methotrexate: new uses for an old drug.J PediatrPrzegląd badań2014
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.Cell SignalPrzegląd badań2014
Wnt signaling in liver fibrosis: progress, challenges and potential directions.BiochimiePrzegląd badań2013
AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy.Trends Mol MedPrzegląd badań2013
From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports?Sports MedPrzegląd badań2013
Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia.Int J Biochem Cell BiolPrzegląd badań2013
Fibroblast growth factor-21 is a promising dietary restriction mimetic.Rejuvenation ResPrzegląd badań2012
Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies.Expert Opin Ther TargetsPrzegląd badań2012
Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level.Adv Exp Med BiolPrzegląd badań2012
AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease.Vascul PharmacolPrzegląd badań2012
AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.OncotargetPrzegląd badań2011
Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?Cell CyclePrzegląd badań2011
LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.Cell CyclePrzegląd badań2011
Novel trends in the treatment of cardiovascular disorders: site- and event- selective adenosinergic drugs.Curr Med ChemPrzegląd badań2011
AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies.Expert Opin Investig DrugsPrzegląd badań2010
Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.Exp Biol Med (Maywood)Przegląd badań2010
Acadesine, an adenosine-regulating agent with the potential for widespread indications.Expert Opin PharmacotherPrzegląd badań2008
LKB1 and AMPK and the regulation of skeletal muscle metabolism.Curr Opin Clin Nutr Metab CarePrzegląd badań2008
The role of AMP kinase in diabetes.Indian J Med ResPrzegląd badań2007
AMP-activated protein kinase and the regulation of glucose transport.Am J Physiol Endocrinol MetabPrzegląd badań2006
Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation.Life SciPrzegląd badań2006
AMP-activated protein kinase and type 2 diabetes.Curr Med ChemPrzegląd badań2006
Sending the signal: molecular mechanisms regulating glucose uptake.Med Sci Sports ExercPrzegląd badań2004
Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle.Proc Nutr SocPrzegląd badań2004
Transgenic models--a scientific tool to understand exercise-induced metabolism: the regulatory role of AMPK (5'-AMP-activated protein kinase) in glucose transport and glycogen synthase activity in skeletal muscle.Biochem Soc TransPrzegląd badań2003
Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity.EndocrinologyPrzegląd badań2003
AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.Acta Physiol ScandPrzegląd badań2003
The role of intramuscular lipid in insulin resistance.Acta Physiol ScandPrzegląd badań2003
AMP-activated protein kinase and muscle glucose uptake.Acta Physiol ScandPrzegląd badań2003
Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'.Biochem Soc TransPrzegląd badań2003
A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals.Biochem Soc TransPrzegląd badań2003
Pemetrexed in pancreatic cancer.Semin OncolPrzegląd badań2002
Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.Curr Drug Targets Immune Endocr Metabol DisordPrzegląd badań2002
Hyperglycemia and insulin resistance: possible mechanisms.Ann N Y Acad SciPrzegląd badań2002
Metabolism of 10-formyldihydrofolate in humans.Biomed PharmacotherPrzegląd badań2001
Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors.OncologistPrzegląd badań2001
AMP-activated protein kinase: possible target for treatment of type 2 diabetes.Diabetes Technol TherPrzegląd badań2000
Acadesine during fluid resuscitation from shock and abdominal sepsis.Crit Care MedPrzegląd badań1999
Cardiopulmonary bypass-induced inflammation: is it important?J Cardiothorac Vasc AnesthPrzegląd badań1998
Inborn errors of the purine nucleotide cycle: adenylosuccinase deficiency.J Inherit Metab DisPrzegląd badań1997
Harnessing an endogenous cardioprotective mechanism: cellular sources and sites of action of adenosine.J Mol Cell CardiolPrzegląd badań1995
Harnessing nature's own cardiac defense mechanism with acadesine, an adenosine regulating agent: importance of the endothelium.J Card SurgPrzegląd badań1994
Acadesine: preclinical overview.Adv Exp Med BiolPrzegląd badań1994
Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury.Cardiovasc ResPrzegląd badań1993
Bilirubin impacts microglial lipophagy via the AMPK-mTOR signaling pathway.Neurochem IntNa zwierzętach2026
[Jiaotaiwan improves lipid metabolism abnormalities in a mouse model of Alzheimer disease by regulating the AMPK signaling pathway].Nan Fang Yi Ke Da Xue Xue BaoNa zwierzętach2026
Hyperglycemia-Induced Loss of Astrocytic Kir4.1 Is Associated with Increased DNMT1 Activity and Altered AMPK/SIRT1 Signaling.CellsNa zwierzętach2026
Sirt3 deficiency impairs AMPK-Acc1 antilipogenic signaling in female adipocytes.Mol Biol RepNa zwierzętach2026
GPR75 knockdown alleviates mitochondrial dysfunction in retinal ganglion cells via AMPK pathway in diabetic mice.Biochem PharmacolNa zwierzętach2026
The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal)3 exposure in HT22 hippocampal neuronal cells.Free Radic Biol MedNa zwierzętach2026
High-Calorie Diet Aggravates Lipopolysaccharide-Induced Pulmonary Inflammation in Juvenile Mice: Association of Acetate-Mediated Macrophage Polarization with AMPK/YAP Signaling.NutrientsNa zwierzętach2026
FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis.Biochem Biophys Res CommunNa zwierzętach2026
LKB1/ AMPK deficiency aggravates mitochondrial DNA leakage via mTOR-dependent mitophagy damage in liver injury sensitized by trichloroethylene.Chem Biol InteractNa zwierzętach2026
AMPK/ULK1 enhances mitophagy and steroidogenesis in duck Granulosa cells under heat exposure.Poult SciNa zwierzętach2026
Gonadotropin-inhibitory hormone (GnIH) induces glycolipid metabolic dysfunction in porcine ovarian granulosa cells via Wnt and AMPK signaling pathways.Mol Cell EndocrinolNa zwierzętach2026
Exercise Preconditioning Activates AMPK-ACC Signaling and Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis.J Cardiovasc Transl ResNa zwierzętach2026
Hypoglycemic conditions enhance neonatal β-cell glucose responsiveness via AMPK/mTOR-increased KATP channel density.EndocrinologyNa zwierzętach2026
MiR-27b-3p suppresses proliferation and testosterone synthesis in goat Leydig cells by activating the AMPK pathway through PPARG targeting.Anim Reprod SciNa zwierzętach2026
SS31 protects damaged retinal cells through the AMPK/DRP1 signaling pathway.Mol VisNa zwierzętach2026
Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway.J Affect DisordNa zwierzętach2026
Energy Stress-Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons.J NeurochemNa zwierzętach2026
AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.Neurochem IntNa zwierzętach2026
Melanocyte proliferation gene 1 regulated metabolic reprogramming in acute myocardial infarction based on the AMPK/mTOR pathway.Toxicol Appl PharmacolNa zwierzętach2026
Sophocarpine prevents LPS and IFN-γ-stimulated oxidative stress and neuroinflammation of BV-2 microglia by regulating the AMPK/NF-κB signaling pathway.Neurol ResNa zwierzętach2026
A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism.JCI InsightNa zwierzętach2026
Metformin Alleviates Cadmium-Induced Autophagic Flux Impairment-Dependent Apoptosis by Activating AMPK in Neuronal Cells.CellsNa zwierzętach2026
Kaempferol alleviates right ventricular hypertrophy in high-altitude pulmonary hypertension rats by modulating the AMPK/ACC/CPT1B axis and the AMPK-mediated LDHA/PDHA1 pathway.Food FunctNa zwierzętach2026
Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK-3β Axis.Kaohsiung J Med SciNa zwierzętach2026
Exercise-Induced Differential Transcriptional Output of AMPK Signaling Improves Axon Regeneration and Functional Recovery.J NeurosciNa zwierzętach2026
[AMP-activated protein kinase activation alleviates lipopolysaccharide-induced sepsis-associated acute kidney injury by inhibiting ferroptosis].Zhonghua Wei Zhong Bing Ji Jiu Yi XueNa zwierzętach2026
Nicorandil ameliorates cardiac microcirculation in hypertensive myocardial infarction via LKB1/AMPK signaling activation.Pak J Pharm SciNa zwierzętach2026
Lactate-Induced Lipid Accumulation in Hepatocytes through GPR81 Activation.Diabetes Metab JNa zwierzętach2026
Short-duration electrical pulse stimulation induces myokines and mitochondrial adaptations in C2C12 myotubes.J Muscle Res Cell MotilNa zwierzętach2026
Electroacupuncture alleviates inflammatory pain through AMPK-autophagy signaling and suppression of iNOS and IL-1β in inflamed tissues.Mol PainNa zwierzętach2026
The AMPK-FOXO signaling regulates the transcriptional response of 4EBP to pesticide stress in Tribolium castaneum.Pestic Biochem PhysiolNa zwierzętach2026
AMPK regulates BK-channel current in CA1 hippocampal neurons.Biochim Biophys Acta Gen SubjNa zwierzętach2025
AICAR Inhibits Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes via an AMPK-Independent, ZMP-Dependent Mechanism.CellsNa zwierzętach2025
A novel long non-coding RNA, Lnc-GAS7, modulates myosin heavy chain isoform switching via AMPK signaling in ovine muscle.Int J Biol MacromolNa zwierzętach2025
Cardiovascular and renal effects of 5-aminoimidazole-4-carboxyribonucleoside (AICAR) in the deoxycorticosterone acetate (DOCA)-salt rat model of hypertension.Life SciNa zwierzętach2025
Aerobic exercise ameliorates skeletal muscle atrophy in atic knockout zebrafish through the oxidative phosphorylation pathway.Free Radic Biol MedNa zwierzętach2025
Nanoparticle-based methionine and AICAR delivery elicits a robust antitumor immune response.J Control ReleaseNa zwierzętach2025
Mechanisms of aerobic exercise on doxorubicin-induced cardiomyocyte apoptosis: based on AMPK/PI3K/AKT signalling pathway.Life SciNa zwierzętach2025
Reprogramming of Myeloid Responses to Volumetric Muscle Loss via Engineered Protein Nanoparticles.ACS NanoNa zwierzętach2025
A comprehensive analysis of meat quality degradation and identification of spoilage markers in chicken during refrigerated storage using multi-method approach.Food ChemNa zwierzętach2025
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide.Nat MetabNa zwierzętach2025
Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway.J Physiol BiochemNa zwierzętach2025
Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle.Calcif Tissue IntNa zwierzętach2025
PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits.Sci RepNa zwierzętach2025
Muscle-specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism.J PhysiolNa zwierzętach2025
BDE-47 induces apoptosis and ferroptosis in Pseudosciaena crocea kidney (PCK) cells by disrupting mitochondrial energy metabolism.Aquat ToxicolNa zwierzętach2025
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.TheranosticsNa zwierzętach2025
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice.Neurochem ResNa zwierzętach2025
Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia.MetabolismNa zwierzętach2025
Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16.FEBS JNa zwierzętach2025
HOPE and AMPK activation reduce reperfusion injury and metabolic dysfunction in primate steatotic liver grafts.Sci RepNa zwierzętach2025
Brain AMPK signaling improves intestinal barrier function through brain orexin and the vagal pathway in rats.Neurosci LettNa zwierzętach2025
Downregulation of NAD Kinase Expression in β-Cells Contributes to the Aging-Associated Decline in Glucose-Stimulated Insulin Secretion.Aging CellNa zwierzętach2025
Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.Exp NeurolNa zwierzętach2025
AMPK agonist AICAR ameliorates maternal hepatic lipid metabolism disorder, inflammation, and fibrosis caused by PM2.5 exposure during pregnancy.Sci RepNa zwierzętach2025
Molecular Mechanism of Aerobic Exercise Ameliorating Myocardial Mitochondrial Injury in Mice with Heart Failure.Int J Mol SciNa zwierzętach2025
Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice.Mol MetabNa zwierzętach2025
Long-term glucosamine supplementation aggravates atrial fibrillation susceptibility by impairing AMPK signaling.Life SciNa zwierzętach2025
Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis.J Innate ImmunNa zwierzętach2025
AMPK activation mitigates inflammatory pain by modulating STAT3 phosphorylation in inflamed tissue macrophages of adult male mice.Mol PainNa zwierzętach2025
Activation of AMPK in platelets promotes the production of offspring.PlateletsW probówce2024
Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease.Proc Natl Acad Sci U S AW probówce2020
Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.Am J Physiol Cell PhysiolW probówce2019
Acute activation of endothelial AMPK surprisingly inhibits endothelium-dependent hyperpolarization-like relaxations in rat mesenteric arteries.Br J PharmacolW probówce2019
Mitochondrial ALDH2 protects against lipopolysaccharide-induced myocardial contractile dysfunction by suppression of ER stress and autophagy.Biochim Biophys Acta Mol Basis DisW probówce2019
High Glucose Upregulated Vascular Smooth Muscle Endothelin Subtype B Receptors via Inhibition of Autophagy in Rat Superior Mesenteric Arteries.Ann Vasc SurgW probówce2018
Homocysteine up-regulates ETB receptors via suppression of autophagy in vascular smooth muscle cells.Microvasc ResW probówce2018
Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old rats.Appl Physiol Nutr MetabW probówce2018
AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias).Am J Physiol Cell PhysiolW probówce2018
Linkage of Metabolic Defects to Activated PIK3CA Alleles in Endothelial Cells Derived from Lymphatic Malformation.Lymphat Res BiolW probówce2018
Studying the Role of AMPK in Cardiac Hypertrophy and Protein Synthesis.Methods Mol BiolW probówce2018
Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: An in vitro and in vivo study.Biochem Biophys Res CommunW probówce2017
Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.Mol Hum ReprodW probówce2017
In vitro progesterone production by luteinized human mural granulosa cells is modulated by activation of AMPK and cause of infertility.Reprod Biol EndocrinolW probówce2017
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside reduces intimal hyperplasia of tissue engineering blood vessel by inhibiting phenotype switch of vascular smooth muscle cell.J Biomed Mater Res B Appl BiomaterW probówce2017
GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.Biochem JW probówce2017
Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.DiabetesW probówce2017
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.Am J Physiol Endocrinol MetabW probówce2016
Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts.Int J CardiolW probówce2016
Cardiotrophin-1 decreases intestinal sugar uptake in mice and in Caco-2 cells.Acta Physiol (Oxf)W probówce2016
Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women.J Physiol BiochemW probówce2015
AMPK Activation Affects Glutamate Metabolism in Astrocytes.Neurochem ResW probówce2015
Analysis of aquaporin expression in liver with a focus on hepatocytes.Histochem Cell BiolW probówce2015
Maintaining Moderate Platelet Aggregation and Improving Metabolism of Endothelial Progenitor Cells Increase the Patency Rate of Tissue-Engineered Blood Vessels.Tissue Eng Part AW probówce2015
AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys.Am J Physiol Renal PhysiolW probówce2015
Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators.PlacentaW probówce2015
Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.J HepatolW probówce2014
Regulatory effect of AMP-activated protein kinase on pulmonary hypertension induced by chronic hypoxia in rats: in vivo and in vitro studies.Mol Biol RepW probówce2014
The effect of small molecules on nuclear-encoded translation diseases.BiochimieW probówce2014
Adiponectin regulates ACTH secretion and the HPAA in an AMPK-dependent manner in pituitary corticotroph cells.Mol Cell EndocrinolW probówce2014
AICAR-induced energy supply and paracrine activity of endothelial cells accelerate chronic diabetic wound healing by promoting angiogenesis and modulating macrophage reprogramming.Mater Today BioInna praca2026
Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells.J Enzyme Inhib Med ChemInna praca2026
Swimming exercise protects against diabetic cardiomyopathy through suppression of FABP4-associated CTRP3 degradation.Cell SignalInna praca2026
NUAK isoforms promote glucose and glutamine metabolic reprogramming driven colon cancer progression and migration through regulation of AMPK/mTOR signaling.J Mol Med (Berl)Inna praca2026
Quantitative Analysis Reveals IL-17A Widens Nasal Epithelial Tight Junction Gaps via AMPK in Allergic Rhinitis.Ann Allergy Asthma ImmunolInna praca2026
AMPK activation stabilizes HIF-2α by disrupting VHL binding and promotes erythroid differentiation under anemic stress via the mTOR pathway.Front PhysiolInna praca2026
PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism.Cardiovasc ResInna praca2026
Impaired fatty acid oxidation and mitochondrial injury mediated by the AMPK/PPARα pathway: A key mechanism in high-fat diet-aggravated ulcerative colitis.PLoS OneInna praca2026
Caffeic acid phenethyl ester inhibits adipogenic differentiation in association with INSR suppression and AMPK activation.Biochim Biophys Acta Gene Regul MechInna praca2026
Simvastatin enhances the antitumor activity of temsirolimus through AMPK-associated metabolic modulation in clear-cell renal cell carcinoma.Naunyn Schmiedebergs Arch PharmacolInna praca2026
Salvianolic Acid A Inhibits Ferroptosis in Endothelial Cells and the Progression of Atherosclerosis by Augmenting the Mitochondrial Homeostasis Pathway Associated With Adiponectin Receptor 1.Phytother ResInna praca2026
AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK-Mediated Mitophagy.Cell ProlifInna praca2026
Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High-Fat Diet-Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction.Adv Sci (Weinh)Inna praca2026
Metabolic reprogramming of decidual macrophages impairs maternal-fetal interface homeostasis and contributes to recurrent spontaneous abortion.Biochem PharmacolInna praca2026
Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.Signal Transduct Target TherInna praca2026
Holistic Regulation of Body-Mind Acupuncture Activates Leptin Receptor-AMPK Signaling to Restore Mitochondrial Homeostasis in Chronic Fatigue Syndrome in vitro and in vivo.Chin J Integr MedInna praca2026
Thapsigargin-induced autophagic flux impairment and inflammation are potentiated by CLN3 deficiency and alleviated by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in human ARPE-19 cells.Biochem Biophys Res CommunInna praca2026
Sub-chronic exposure to lanthanum chloride induces hepatic steatosis via AMPK-dependent lipophagic defects in male zebrafish.Ecotoxicol Environ SafInna praca2026
AMPK activation by AICAR mitigates hypoxic corneal damage through rebuilding energy and metabolic homeostasis.Chem Biol InteractInna praca2026
N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro.Drug Chem ToxicolInna praca2026
Obesity-related palmitic acid exacerbates IL-13-induced mucus phenotype in 16HBE airway epithelial cells via AMPK suppression.Transl PediatrInna praca2026
Berberine Regulates Hepatic Fatty Acid Metabolism via AMPK/SIRT1/PGC-1α Pathway.Chin J Integr MedInna praca2026
Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition.MetabolitesInna praca2026
Pharmacological inhibition of TRPM4 channel stabilizes atherosclerotic plaque via inhibiting AMPK-Beclin1-mediated autophagy.Eur J PharmacolInna praca2026
AMPK-driven immunometabolic reprogramming enhances CD19+CD21hiCD24hi regulatory B-cell-mediated suppression of atopic dermatitis.J Allergy Clin ImmunolInna praca2026
[Costunolide improves sorafenib-induced cardiomyocyte injury by inhibiting mitophagy].Zhongguo Zhong Yao Za ZhiInna praca2026
AMPK orchestrates mitochondrial homeostasis via dynamics and mitophagy to combat hypoxia-induced energetic crisis in keratocytes.Cell Biol ToxicolInna praca2026
Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.Chem Biol InteractInna praca2026
5-Aminoimidazole-4-carboxamide riboside, an AMPK activator, enhances TRAIL-mediated apoptosis in human bladder cancer cells in a p38 MAPK-dependent manner.Genes GenomicsInna praca2026
Impaired AMP-Dependent Protein Kinase-Mediated Neutrophil Extracellular Trap Clearance by Aged Macrophages in Sepsis-Induced Liver Injury.Anesth AnalgInna praca2026
Serum Starvation Promotes the Proteolysis of OGT by Activating AMPK and the CUL1/SKP1/SKP2 E3 Ubiquitin Ligase in 3T3-L1 Cells.Biomol Ther (Seoul)Inna praca2026
Developmental lead (pb) exposure induces anxiety and depression-like behaviors via inhibiting the AMPK/ACSS2 pathway.Curr Res ToxicolInna praca2026
Plasma proteomics stratification identifies phospholamban R14del carriers at risk for disease progression.Cardiovasc ResInna praca2026
Spatially resolved in vivo ratiometric imaging of mitochondrial quality control using co-registered confocal-OCT.Biomed Opt ExpressInna praca2026
RAB5A regulates cell proliferation and lipid metabolism by modulating mitochondrial ROS via AMPK signaling pathway in ovarian granulosa cells.Redox BiolInna praca2026
Metformin inhibits PDGFβ signaling to suppress hyaluronan and cytokine production in thyroid eye disease.Exp Eye ResInna praca2026
The role of NPY in liver transplantation from extended-criteria donors.Free Radic Biol MedInna praca2026
AMPK promotes TFEB transcriptional activity through dephosphorylation at both MTORC1-dependent and -independent sites.AutophagyInna praca2026
5-Aminoimidazole-4-carboxamide-1- β ${\bf {\beta}}$ -d-ribofuranoside ameliorates lipotoxicity through enhanced reticulophagy in HepG2 cells.Biotechnol Appl BiochemInna praca2026
Neuroprotective effects of Platycladus orientalis ethyl acetate fraction on retinal Müller cells: modulation of AKT1/mTOR and Raf-1/MEK1/2 pathways via AMPK activation.Front Mol BiosciInna praca2026
Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress.Equine Vet JInna praca2026
AMPK-p38 axis converts human pluripotent stem cells to naive state.iScienceInna praca2026
Purine Metabolism Regulates the Severity of APOL1 Nephropathy.J Am Soc NephrolInna praca2026
Roles of RRM2 and RRM2B in pyrimidine stress responses and differentiation of acute myeloid leukemia cells.Cell Death DiscovInna praca2026
Rapid Analysis of Urinary AICAR by Liquid Chromatography-Isotope Ratio Mass Spectrometry.Anal ChemInna praca2026
TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling.Curr Issues Mol BiolInna praca2026
The AMPK activator A769662 promotes ferroptosis and suppresses disulfidptosis by inhibiting SLC7A11.Biochem Biophys Res CommunInna praca2026
Elevated Kallistatin Induces Myosteatosis and Exercise Intolerance by Antagonizing AdipoR1-Mediated AMPK Signalling.J Cachexia Sarcopenia MuscleInna praca2026
MFN2 interacts with phosphorylated AMPK to mediate mitophagy in MCF-7 cells.Int J Biochem Cell BiolInna praca2026
Mechanistic study of miR-148a-3p-mediated AMPK/mTOR/S6-dependent autophagy in hepatitis B virus replication.Virus GenesInna praca2026
Organophosphate pesticide DEDT promotes diabetic retinopathy progression via AMPK/Nrf2/HO-1 pathway.Sci RepInna praca2026
The role of autophagy in microwave radiation induced toxicity in iPSC-derived cardiomyocytes.Curr Res ToxicolInna praca2026
The fungistatic mechanism of benzaldehyde against the nematophagous fungus Arthrobotrys oligospora suggests a method for manipulating soil fungistasis.Commun BiolInna praca2026
A novel Chinese medicine formula against hyperuricemia-induced kidney inflammation involving pyroptosis inhibition via modulating AMPK-TLR4-NLRP3 pathway.Chin MedInna praca2026
Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease.DiabetologiaInna praca2026
Ex vivo lung perfusion enhances donor lung preservation in mice via Hippo signaling activation.Am J Respir Cell Mol BiolInna praca2026
FNDC5/Irisin-dependent renoprotection of resistance training in myocardial infarction-induced Type 2 cardiorenal syndrome.PLoS OneInna praca2026
Regulation of ovarian maturation in Macrobrachium nipponense by the ribonucleotide reductase M1 subunit.Mar Life Sci TechnolInna praca2026
Vitamin A-activated PPARγ signaling enhances intramuscular fat accumulation by overriding AMPK-mediated inhibition in late-fattening beef cattle.J Anim Sci BiotechnolInna praca2026
AICAR attenuates ischemia-reperfusion-induced AKI by modulating AMPK-TXNIP-NLRP3 pathway and energy metabolism.Cell Mol Life SciInna praca2026

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