| Safety and Metabolism-Related Outcomes of Oral Nicotinamide Mononucleotide Supplementation in Adults: A Systematic Review and Meta-Analysis.Nutrients | Pooled analysis | 2026 |
| Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients | Pooled analysis | 2026 |
| The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.J Cachexia Sarcopenia Muscle | Pooled analysis | 2025 |
| Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Curr Pharm Biotechnol | Pooled analysis | 2025 |
| Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials.Crit Rev Food Sci Nutr | Pooled analysis | 2025 |
| Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.Curr Diab Rep | Pooled analysis | 2024 |
| Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis.Front Public Health | Pooled analysis | 2023 |
| Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise.J Int Soc Sports Nutr | Random groups | 2026 |
| Sublingual NMN administration increases early circulating terminal catabolites 2PY and 4PY compared with oral administration in healthy adult men.Sci Rep | Random groups | 2026 |
| Association between blood nicotinamide adenine dinucleotide levels and blood laboratory parameters at baseline and after nicotinamide mononucleotide supplementation in middle-aged healthy individuals: post hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial.Geroscience | Random groups | 2026 |
| Effect of Nicotinamide Mononucleotide on Retinal Thickness of Older Patients With Diabetes Mellitus: A Placebo-Controlled, Double-Blind Study.Geriatr Gerontol Int | Random groups | 2026 |
| The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study.Sci Rep | Random groups | 2026 |
| The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.Nat Metab | Random groups | 2026 |
| MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults.J Gerontol A Biol Sci Med Sci | Random groups | 2023 |
| Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study.Geriatr Gerontol Int | Random groups | 2023 |
| Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.Sci Rep | Random groups | 2022 |
| Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study.Nutrients | Random groups | 2022 |
| Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.J Int Soc Sports Nutr | Random groups | 2021 |
| Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.J Med Food | Random groups | 2020 |
| Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.Nat Med | No random groups | 2026 |
| The acute effect of different NAD+ precursors included in the combined metabolic activators.Free Radic Biol Med | No random groups | 2023 |
| Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men.BMC Geriatr | No random groups | 2023 |
| Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.Endocr J | No random groups | 2020 |
| An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.PLoS One | No random groups | 2017 |
| Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans.Diabetologia | No random groups | 2011 |
| Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery.Sci Rep | Group followed over time | 2024 |
| Exploring the therapeutic potential of β-nicotinamide mononucleotide (NMN) in regulating canine NT-proBNP levels.J Adv Vet Anim Res | Case reports | 2026 |
| NMNAT3 deficiency: a novel red blood cell enzymopathy causing hemolysis by altering NAD levels and glycolysis.Blood | Case reports | 2025 |
| New Insights on the Genetic Basis Underlying SHILCA Syndrome: Characterization of the NMNAT1 Pathological Alterations Due to Compound Heterozygous Mutations and Identification of a Novel Alternative Isoform.Int J Mol Sci | Case reports | 2021 |
| Generation of a human induced pluripotent stem cell line from a patient with Leber congenital amaurosis.Stem Cell Res | Case reports | 2020 |
| Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence.Exp Neurol | Case reports | 2019 |
| Clinical and genetic findings in a family with NMNAT1-associated Leber congenital amaurosis: case report and review of the literature.Graefes Arch Clin Exp Ophthalmol | Case reports | 2015 |
| NMNAT1 mutations cause Leber congenital amaurosis.Nat Genet | Case reports | 2012 |
| Lysine Acetylation as a Regulatory Mechanism in Cardiometabolic Disease: A Focus on Sirtuins.Pharmaceuticals (Basel) | Review of studies | 2026 |
| NAD+ signaling in Parkinson's disease: molecular mechanisms and therapeutic perspectives.Front Neurol | Review of studies | 2026 |
| Restoring NAD+ pathways in brain aging and neurodegenerative diseases: roles of vitamin B3 metabolites, gut microbiota, and exercise in cognitive health.Front Nutr | Review of studies | 2026 |
| Therapeutic Targeting of Inflammaging and Emerging Strategies for Managing Age-Related Multimorbidity: A Narrative Review.Clin Interv Aging | Review of studies | 2026 |
| Narrative review of intravenous NAD+ and NAD+ precursors in wellness and translational medicine.Front Aging | Review of studies | 2026 |
| Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging.Metabolites | Review of studies | 2026 |
| SARM1 executes neuronal parthanatos and promotes excitotoxic cell death.Neuron | Review of studies | 2026 |
| NAD⁺ biology and supplementation: From mechanisms to clinical perspectives.Mol Biol Rep | Review of studies | 2026 |
| Clinical and biochemical footprints of inherited cofactor disorders.Mol Genet Metab | Review of studies | 2026 |
| Role of nicotinamide adenine dinucleotide in cardiovascular disease.Curr Opin Cardiol | Review of studies | 2026 |
| Exogenous Nucleotides as Functional Food Supplements: A Bibliometric Analysis of Global Research Trends (2000-2025).Foods | Review of studies | 2026 |
| Green manufacturing synthesis of nicotinamide mononucleotide: Pathways, catalysts, and prospects.Bioorg Chem | Review of studies | 2026 |
| Sarcopenia and satellite cell homeostasis disruption: the dual function of NAD+ metabolism.Front Nutr | Review of studies | 2026 |
| An integrated anti-aging framework targeting NAD+ homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT.Redox Biol | Review of studies | 2026 |
| DLK, NMNAT2, and SARM1: Judge, Jury, and Executioner in Axon Degeneration.Annu Rev Biochem | Review of studies | 2026 |
| DRP1 in reproduction and reproductive aging.Biol Reprod | Review of studies | 2026 |
| Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use.Ageing Res Rev | Review of studies | 2026 |
| NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis.J Assist Reprod Genet | Review of studies | 2026 |
| NAD+ precursors mitigate the in vitro and in vivo reproductive defects: Limitations and possible solutions.Reprod Toxicol | Review of studies | 2025 |
| Preventive and Protective Effects of Nicotinamide Adenine Dinucleotide Boosters in Aging and Retinal Diseases.Int J Mol Sci | Review of studies | 2025 |
| The interplay of NAD+, hyperuricemia, and renal damage: A scientific review.Pathol Res Pract | Review of studies | 2025 |
| The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology.Int J Mol Sci | Review of studies | 2025 |
| Emerging strategies, applications and challenges of targeting NAD+ in the clinic.Nat Aging | Review of studies | 2025 |
| Network of nicotinamide mononucleotide biosynthesis: substrate tracking, rate-limiting enzyme, and regulatory strategy.Synth Syst Biotechnol | Review of studies | 2025 |
| Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.J Hematol Oncol | Review of studies | 2025 |
| Evaluation of the Role of PnuC Gene in Enhancing Nicotinamide Mononucleotide Synthesis.Biotechnol Appl Biochem | Review of studies | 2025 |
| Biological production of nicotinamide mononucleotide: a review.Crit Rev Biotechnol | Review of studies | 2025 |
| Nicotinamide and Pyridoxine in Muscle Aging: Nutritional Regulation of Redox, Inflammation, and Regeneration.Antioxidants (Basel) | Review of studies | 2025 |
| Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges.Biogerontology | Review of studies | 2025 |
| Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome.Drug Des Devel Ther | Review of studies | 2025 |
| Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective.Nutrients | Review of studies | 2025 |
| Microbial Production of Nicotinamide Mononucleotide: Key Enzymes Discovery, Host Cells Selection, and Pathways Design and Optimization.ACS Synth Biol | Review of studies | 2025 |
| NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control.NPJ Aging | Review of studies | 2025 |
| Reactivating Circadian Rhythms as a Therapeutic Strategy: Insights from Basic Research.Biol Pharm Bull | Review of studies | 2025 |
| [Research progress on anti-aging effects of β-nicotinamide mononucleotide (NMN)].Sheng Li Xue Bao | Review of studies | 2024 |
| Harnessing lactic acid bacteria for nicotinamide mononucleotide biosynthesis: a review of strategies and future directions.Front Microbiol | Review of studies | 2024 |
| An overview of engineering microbial production of nicotinamide mononucleotide.J Biotechnol | Review of studies | 2024 |
| Function of NAD metabolism in white adipose tissue: lessons from mouse models.Adipocyte | Review of studies | 2024 |
| NAD+ enhancers as therapeutic agents in the cardiorenal axis.Cell Commun Signal | Review of studies | 2024 |
| The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases.Front Mol Biosci | Review of studies | 2024 |
| The versatile multi-functional substance NMN: its unique characteristics, metabolic properties, pharmacodynamic effects, clinical trials, and diverse applications.Front Pharmacol | Review of studies | 2024 |
| Mitochondria as therapeutic targets in assisted reproduction.Hum Reprod | Review of studies | 2024 |
| Regulation of and challenges in targeting NAD+ metabolism.Nat Rev Mol Cell Biol | Review of studies | 2024 |
| Research advances in the function and anti-aging effects of nicotinamide mononucleotide.J Zhejiang Univ Sci B | Review of studies | 2024 |
| Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases.Int J Mol Sci | Review of studies | 2024 |
| Advancements in NMN biotherapy and research updates in the field of digestive system diseases.J Transl Med | Review of studies | 2024 |
| Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials.Cureus | Review of studies | 2024 |
| Dual-targeted NAMPT inhibitors as a progressive strategy for cancer therapy.Bioorg Chem | Review of studies | 2024 |
| Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary.FASEB J | Review of studies | 2024 |
| Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide.Nutrients | Review of studies | 2024 |
| Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans.Phytomedicine | Review of studies | 2024 |
| Ability of NAD and Sirt1 to epigenetically suppress albuminuria.Clin Exp Nephrol | Review of studies | 2024 |
| Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications.Metabolites | Review of studies | 2024 |
| The therapeutic perspective of NAD+ precursors in age-related diseases.Biochem Biophys Res Commun | Review of studies | 2024 |
| Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging.Aging Dis | Review of studies | 2024 |
| Metabolites in aging and aging-relevant diseases: Frailty, sarcopenia and cognitive decline.Geriatr Gerontol Int | Review of studies | 2024 |
| Nicotinamide mononucleotide, a potential future treatment in ocular diseases.Graefes Arch Clin Exp Ophthalmol | Review of studies | 2024 |
| Biosynthesis of Nicotinamide Mononucleotide: Synthesis Method, Enzyme, and Biocatalytic System.J Agric Food Chem | Review of studies | 2024 |
| The Role of NAD+ and NAD+-Boosting Therapies in Inflammatory Response by IL-13.Pharmaceuticals (Basel) | Review of studies | 2024 |
| Inhibitors of NAD+ Production in Cancer Treatment: State of the Art and Perspectives.Int J Mol Sci | Review of studies | 2024 |
| Human trials exploring anti-aging medicines.Cell Metab | Review of studies | 2024 |
| Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives.Bioorg Med Chem | Review of studies | 2024 |
| The Role of NMNAT2/SARM1 in Neuropathy Development.Biology (Basel) | Review of studies | 2024 |
| NAD+ Boosting Strategies.Subcell Biochem | Review of studies | 2024 |
| Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach.J Alzheimers Dis | Review of studies | 2024 |
| Nicotinamide Mononucleotide in the Context of Myocardiocyte Longevity.Curr Aging Sci | Review of studies | 2024 |
| The concept of gene therapy for glaucoma: the dream that has not come true yet.Neural Regen Res | Review of studies | 2024 |
| Glaucoma: neuroprotection with NAD-based therapeutic interventions.Trends Pharmacol Sci | Review of studies | 2023 |
| NAD+, Axonal Maintenance, and Neurological Disease.Antioxid Redox Signal | Review of studies | 2023 |
| NAD+ Precursors in Human Health and Disease: Current Status and Future Prospects.Antioxid Redox Signal | Review of studies | 2023 |
| Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.J Gerontol A Biol Sci Med Sci | Review of studies | 2023 |
| Mechanism of initiation and regulation of axonal degeneration with special reference to NMNATs and Sarm1.Neurosci Res | Review of studies | 2023 |
| The Molecular Mechanisms Involved in Axonal Degeneration and Retrograde Retinal Ganglion Cell Death.DNA Cell Biol | Review of studies | 2023 |
| The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.Adv Nutr | Review of studies | 2023 |
| The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance.Biomedicines | Review of studies | 2023 |
| NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health.Curr Nutr Rep | Review of studies | 2023 |
| Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives.Molecules | Review of studies | 2023 |
| Technology and functional insights into the nicotinamide mononucleotide for human health.Appl Microbiol Biotechnol | Review of studies | 2023 |
| [Advances in physiological activities and synthesis of β-nicotinamide mononucleotide].Sheng Wu Gong Cheng Xue Bao | Review of studies | 2023 |
| NMNAT2: An important metabolic enzyme affecting the disease progression.Biomed Pharmacother | Review of studies | 2023 |
| Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.Nutrients | Review of studies | 2023 |
| Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders.Drugs Aging | Review of studies | 2023 |
| Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases.Int J Mol Sci | Review of studies | 2022 |
| Nutraceutical activation of Sirt1: a review.Open Heart | Review of studies | 2022 |
| NAD+ Therapeutics and Skeletal Muscle Adaptation to Exercise in Humans.Sports Med | Review of studies | 2022 |
| A Narrative Review of Nicotinamide Adenine Dinucleotide (NAD)+ Intermediates Nicotinamide Riboside and Nicotinamide Mononucleotide for Keratinocyte Carcinoma Risk Reduction.J Drugs Dermatol | Review of studies | 2022 |
| The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.Mol Biol Rep | Review of studies | 2022 |
| Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts.Nutrients | Review of studies | 2022 |
| The chemical biology of NAD+ regulation in axon degeneration.Curr Opin Chem Biol | Review of studies | 2022 |
| From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases.Front Pharmacol | Review of studies | 2022 |
| The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions.IUBMB Life | Review of studies | 2022 |
| SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease.Oxid Med Cell Longev | Review of studies | 2022 |
| Bazi Bushen attenuates musculoskeletal degeneration in Ercc1+/- mice.Exp Gerontol | In animals | 2026 |
| Modulating hepatic hypoxanthine metabolism relieve metabolic stress-related neurovascular resilience disturbance via the liver-brain axis.Free Radic Biol Med | In animals | 2026 |
| Nicotinamide Mononucleotide Does Not Prevent Cardiac Hypertrophy but Attenuates Cardiac Stress and Remodeling Markers in Mice Exposed to Intermittent Normobaric Hypoxia.Nutrients | In animals | 2026 |
| PEGylated nicotinamide mononucleotide targeted ferroptosis in acute kidney injury by suppressing FAR1 palmitoylation in an ACAA1-dependent manner.Int J Biol Sci | In animals | 2026 |
| Macrophage-derived CD38 mediates colitis through NAD+ depletion.J Physiol | In animals | 2026 |
| Nicotinamide Mononucleotide Combined Glucose Counteracts Iron Overload-Induced Mitochondrial Dysfunction in Mice Under Hypobaric Hypoxia.Mol Cell Proteomics | In animals | 2026 |
| β-Nicotinamide mononucleotide reduces aflatoxin B1 induced liver injury via the gut microbiota-bile acid-farnesoid X receptor (FXR/NR1H4) axis.Br J Pharmacol | In animals | 2026 |
| Fetal hypoxia causes oocyte oxidative stress damage via the Sirt3/Sod2 pathway and can be alleviated by nicotinamide mononucleotide.Zool Res | In animals | 2026 |
| Nicotinamide mononucleotide (NMN) improves the ovarian microenvironment associated with oocyte quality by increasing estrogen signaling, reprogramming ovarian metabolism, reducing oxidative stress, and inhibiting apoptosis in the spotted scat (Scatophagus argus).Theriogenology | In animals | 2026 |
| Nicotinamide mononucleotide alleviates the streptozotocin-mediated ferroptosis of islet β-cells via the Nrf2/GPX4 pathway.Braz J Med Biol Res | In animals | 2026 |
| Nicotinamide Mononucleotide Ameliorates Myocardial Fibrosis in Diabetic Mice Possibly by Modulating SIRT3 to Deacetylate GSK3β and Thereby Reducing the Phosphorylation of Smad3.J Cardiovasc Transl Res | In animals | 2026 |
| Investigation of the effects of nicotinamide mononucleotide on kidney damage in rats with cecal ligation and perforation sepsis model.Acta Cir Bras | In animals | 2026 |
| Restorin® NR is a Highly Efficient NAD+ Precursor.Drug Des Devel Ther | In animals | 2026 |
| Real-Time Two-Photon Imaging of Brain Endothelial NAD+ Metabolism in Mice.J Vis Exp | In animals | 2026 |
| Investigating the effects of nicotinamide mononucleotide administration on testicular apoptosis, and mitochondrial function in doxorubicin-treated rats.Mol Biol Rep | In animals | 2026 |
| Elamipretide (SS-31) and Nicotinamide Mononucleotide (NMN) Combination Therapy Targets TREM2 to Mitigate Post-ischemic Brain Injury in Mice.Neurochem Res | In animals | 2026 |
| Comparative lipidomics and NAD⁺ metabolism in pectoris muscle reveal a lean metabolic phenotype in Daweishan miniature chickens versus arbor acre broilers.Poult Sci | In animals | 2026 |
| Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans.Phytochemistry | In animals | 2026 |
| Sleep-wake and circadian behavior in brain-specific sirtuin 1 knockout mice and effects of nicotinamide mononucleotide supplementation.Sci Rep | In animals | 2026 |
| Hepatic Hamp restoration contributes to nicotinamide mononucleotide (NMN)-alleviated hepatic steatosis in chronic alcohol-fed mice.Commun Biol | In animals | 2026 |
| Nicotinamide Mononucleotide Ameliorates Nano-Aluminum Oxide-Induced Cognitive Impairment and Ferroptosis via the GSH/GPX4 Axis.Small | In animals | 2026 |
| Role of NMDAR-NMNAT in sevoflurane exposure-induced learning memory deficits.Brain Dev | In animals | 2026 |
| Nicotinamide Mononucleotide Reduces Iron in BV-2 Cell by Up-Regulating Ferroportin 1 via Inhibiting the IL-6/STAT3/Hepcidin Pathway.Rejuvenation Res | In animals | 2026 |
| Nicotinamide Mononucleotide Improves High-Fat Diet-Induced Myocardial Damage of Aging Mice through the Sirt3/PINK1/Parkin Signaling Pathway.J Nutr | In animals | 2026 |
| Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice.Biochem Biophys Res Commun | In animals | 2026 |
| Stabilization of high internal phase emulsions by chitooligosaccharide‑sodium tripolyphosphate complexes: Application in enhancing stability and bioaccessibility of nicotinamide mononucleotide and Antarctic krill oil.Food Chem | In animals | 2026 |
| SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways.Drug Des Devel Ther | In animals | 2026 |
| NMN Can Restore Ovarian Reserve in Aged Mice by Upregulating NAD+/SIRT1/PGC-1α Signaling Pathway and TOMM20 Expression, and Improve in Vitro Development of Aging Oocytes.Reprod Sci | In animals | 2026 |
| Nicotinamide mononucleotide supplementation modulates gut microbiota and metabolites to mitigate Alzheimer's disease pathology in APP/PS1 mice.J Alzheimers Dis | In animals | 2026 |
| Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming.EBioMedicine | In animals | 2026 |
| Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells.J Hazard Mater | In animals | 2026 |
| β-Nicotinamide mononucleotide preserves muscle strength in septic male mice.Sci Rep | In animals | 2026 |
| The combination of Anoectochilus roxburghii and Danggui-Niantong decoction ameliorates hyperuricemia by regulating NAD+ metabolism and urate transport in rats.Phytomedicine | In animals | 2026 |
| Elastic cationic liposomal nanogels: a novel platform for topical nicotinamide mononucleotide delivery.J Liposome Res | In animals | 2026 |
| NAD + -Boosting Ameliorates Heme Protein-Mediated Acute Kidney Injury.Kidney360 | In animals | 2026 |
| NMN/NAD+/SIRT1 axis activates NAMPT to ameliorate H2O2-triggered the impairment of progesterone synthesis in ovarian granulosa cells.J Ovarian Res | In animals | 2026 |
| Reduced Versus Oxidized NAD+ Precursors Drive Distinct Transcriptomic, Proteomic, and Metabolic Profiles in Hepatocytes.FASEB J | In animals | 2026 |
| Nicotinamide mononucleotide attenuates hyperandrogenism in a polycystic ovary syndrome-like rat model by suppressing NLRP3 inflammasome-mediated granulosa-cell pyroptosis.J Ovarian Res | In animals | 2026 |
| β-Nicotinamide Mononucleotide protects against endotoxemia-induced myocardial injury through Sirt5-dependent desuccinylation of succinate dehydrogenase.Eur J Pharmacol | In animals | 2026 |
| Nicotinamide mononucleotide rescues perinatal arsenic-induced autism-like behaviours via modulation of NAD+ metabolism in mice.Ecotoxicol Environ Saf | In animals | 2026 |
| Beta-nicotinamide mononucleotide attenuates creatine kinase release in Duchenne muscular dystrophy model rats.J Vet Med Sci | In animals | 2026 |
| Nicotinamide mononucleotide improves spermatogenesis in aluminium-exposed mice by inhibiting NLRP3-mediated pyroptosis.PLoS One | In animals | 2026 |
| ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness.Sci Adv | In animals | 2026 |
| NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1.Adv Sci (Weinh) | In animals | 2026 |
| The Mechanism of Action of NMN in Inhibiting NLRP3 Acetylation-Mediated Granulosa Cell Pyroptosis to Improve Ovarian Reserve Function in Ionizing Radiation-Exposed Mice.FASEB J | In animals | 2025 |
| Sirtuins may mediate temperature-induced metabolic remodeling in threespine stickleback.J Comp Physiol B | In animals | 2025 |
| Nicotinamide mononucleotide supplement combined with prolonging maturation time improves the quality of oocytes cultured in vitro.Anim Reprod Sci | In animals | 2025 |
| FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NAD+ replenishment as a redox-targeted antioxidant therapy.Redox Rep | In animals | 2025 |
| Protective effect of nicotinamide mononucleotide against soybean isoflavone induced damage in mouse testis.Reprod Biol | In animals | 2025 |
| The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence.Free Radic Biol Med | In animals | 2025 |
| Nicotinamide mononucleotide treatment improves spermatogenesis in obese mice by reducing lysine acetylation of lactate dehydrogenase C.Commun Biol | In animals | 2025 |
| Vascular Endothelial NAMPT-Mediated NAD+ Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice.Aging Cell | In animals | 2025 |
| Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.Toxicol Appl Pharmacol | In animals | 2025 |
| Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in mice.PLoS One | In animals | 2025 |
| Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice.Nutrients | In animals | 2025 |
| Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice.Endocr J | In animals | 2025 |
| Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice.Part Fibre Toxicol | In animals | 2025 |
| Sodium dehydroacetate induces porcine oocyte toxicity by inhibiting TCA cycle activity and mitochondrial function, with nicotinamide mononucleotide as a potential protective agent.Food Chem Toxicol | In animals | 2025 |
| β-Nicotinamide mononucleotide protects against hypervirulent Klebsiella pneumoniae bloodstream infection and liver injury.mSphere | In animals | 2025 |
| Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia.Biogerontology | In animals | 2025 |
| Biosensor-driven adaptive laboratory evolution and modular pathway engineering for high-level production of nicotinamide mononucleotide in yeast.Bioresour Technol | In a lab dish | 2026 |
| Development of a noncanonical redox cofactor platform in Saccharomyces cerevisiae.Metab Eng | In a lab dish | 2026 |
| Continuous production of nicotinamide mononucleotide by engineered Escherichia coli: effect of dilution rate and glucose feeding.Bioprocess Biosyst Eng | In a lab dish | 2026 |
| Enhancing production of nicotinamide mononucleotide by metabolic engineering and flow cytometry screening of Escherichia coli.Biotechnol Lett | In a lab dish | 2025 |
| NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos.Commun Biol | In a lab dish | 2025 |
| Establishing a novel pathway for the biosynthesis of nicotinamide mononucleotide.Enzyme Microb Technol | In a lab dish | 2025 |
| Enhancing nicotinamide mononucleotide production in Escherichia coli through systematic metabolic engineering.J Biotechnol | In a lab dish | 2025 |
| Nicotinamide Mononucleotide Production in Metabolically Engineered Saccharomyces cerevisiae.ACS Synth Biol | In a lab dish | 2025 |
| Metabolic reprogramming and machine learning-guided cofactor engineering to boost nicotinamide mononucleotide production in Escherichia coli.Bioresour Technol | In a lab dish | 2025 |
| Improving Biosynthesis Efficiency of Nicotinamide Mononucleotide by ATP Recycling Engineering and Condition Optimization.J Agric Food Chem | In a lab dish | 2025 |
| Senescent alveolar type II epithelial cells-secreted GDF15 promotes silicosis progression via interfering intercellular communication.Ecotoxicol Environ Saf | In a lab dish | 2025 |
| High-Level Production of Nicotinamide Mononucleotide by Engineered Escherichia Coli.J Agric Food Chem | In a lab dish | 2024 |
| De novo biosynthesis and nicotinamide biotransformation of nicotinamide mononucleotide by engineered yeast cells.Microb Biotechnol | In a lab dish | 2024 |
| Exploring the De Novo NMN Biosynthesis as an Alternative Pathway to Enhance NMN Production.ACS Synth Biol | In a lab dish | 2024 |
| Evaluation of NAD+ precursors for improved metabolism and productivity of antibody-producing CHO cell.Biotechnol J | In a lab dish | 2024 |
| Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy.Adv Sci (Weinh) | In a lab dish | 2024 |
| A holistic approach for process intensification of nicotinamide mononucleotide production via high cell density cultivation under exponential feeding strategy.Bioresour Technol | In a lab dish | 2023 |
| Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures.Sci Rep | In a lab dish | 2023 |
| Rapid prototyping enzyme homologs to improve titer of nicotinamide mononucleotide using a strategy combining cell-free protein synthesis with split GFP.Biotechnol Bioeng | In a lab dish | 2023 |
| Biotechnological production of reduced and oxidized NAD+ precursors.Food Res Int | In a lab dish | 2023 |
| Biosynthesis of a Therapeutically Important Nicotinamide Mononucleotide through a Phosphoribosyl Pyrophosphate Synthetase 1 and 2 Engineered Strain of Escherichia coli.ACS Synth Biol | In a lab dish | 2021 |
| Metabolic engineering of Escherichia coli for biosynthesis of β-nicotinamide mononucleotide from nicotinamide.Microb Biotechnol | In a lab dish | 2021 |
| Generation and assessment of high-quality mouse oocytes and embryos following nicotinamide mononucleotide administration.STAR Protoc | In a lab dish | 2021 |
| Synthesis of functional oligosaccharides and their derivatives through cocultivation and cellular NTP regeneration.Adv Appl Microbiol | In a lab dish | 2021 |
| Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor.Microb Cell Fact | In a lab dish | 2020 |
| Bacteroides-associated NAD⁺ depletion correlates with exacerbated radiation-induced colorectal injury and impaired mucosal proliferative capacity.Gut Microbes | Other paper | 2026 |
| pH-responsive chitosan-based nanoparticles for targeted delivery of nicotinamide mononucleotide in acute kidney injury therapy.Colloids Surf B Biointerfaces | Other paper | 2026 |
| Dual-targeted pH-responsive nanoliposome (M5/NMN/DEAP/iRGD-Lip): Immunostimulatory-photodynamic synergy for breast cancer therapy.Colloids Surf B Biointerfaces | Other paper | 2026 |
| A senescent metabolism-modulating hierarchical scaffold restores NAD+ homeostasis and redox balance for aged bone repair.Bioact Mater | Other paper | 2026 |
| NAD+ precursor supplementation reverses CD36-mediated lipid accumulation and ferroptosis to restore antitumor function of NK cells in DLBCL.Pharm Sci Adv | Other paper | 2026 |
| Hepatoprotective Effect of Nicotinamide Mononucleotide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.Food Sci Nutr | Other paper | 2026 |
| Local inhibition of glaucomatous mitochondrial dysfunction using an engineered annular sector microneedle.Biomaterials | Other paper | 2026 |
| Nuclear NAD+ promotes innate immune memory by inhibiting KDM5A-dependent histone demethylation.Sci Immunol | Other paper | 2026 |
| Revealing NMN-induced biomacromolecular complex and conformational regulation of digestive enzymes (Trypsin, Pepsin, α-Amylase): Insights from molecular dynamics simulation and multi-spectroscopy.Biochem Pharmacol | Other paper | 2026 |
| NMN Ameliorates STXBP1-R292C Variant-mediated Developmental and Motor Dysfunction: Molecular Docking and Functional Studies.J Mol Neurosci | Other paper | 2026 |
| Nicotinamide Mononucleotide Is Associated with Attenuation of OGD/R-Induced Pro-Inflammatory Programs in Microglia: Transcriptomic Evidence Converging on the NLRP3 Inflammasome and Lipid-Droplet-Related Molecular Signatures.Biomedicines | Other paper | 2026 |
| Nicotinamide mononucleotide supplementation improves polycystic ovary syndrome by activating silent regulatory protein 2 mediated lactate dehydrogenase A lysine 119 deacetylation to enhance glycolytic activity.Int J Biol Macromol | Other paper | 2026 |
| Smpd2 m6A modification contributes to hypoxic pulmonary hypertension via an alveolar epithelial cell senescence-associated phenotype.Tissue Cell | Other paper | 2026 |
| Platelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p.Exp Mol Med | Other paper | 2026 |
| Nicotinamide Mononucleotide-Producing Probiotic Strain B12-N Attenuates Aging and Cognitive Decline in a Caenorhabditis elegans Model of Alzheimer's Disease: Efficacy and Underlying Mechanisms.Foods | Other paper | 2026 |
| Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging.Adv Sci (Weinh) | Other paper | 2026 |
| Nicotinamide mononucleotide supports the development of bovine embryo through enhancement of mitochondrial function in morula.Reproduction | Other paper | 2026 |
| Reversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset.Exploration (Beijing) | Other paper | 2026 |
| Purine availability determines survival of complex I-deficient fibroblasts under OXPHOS-reliant condition.Mitochondrion | Other paper | 2026 |
| Semi-Rational Design of CpNampt Mutants for Enhanced Nicotinamide Mononucleotide (NMN) Synthesis in Saccharomyces cerevisiae.Microb Physiol | Other paper | 2026 |
| Magnesium Phosphate Composite Hydrogel Dressing Promotes Diabetic Wound Repair Through Anti-Inflammatory, Antioxidant, Angiogenic, and Metabolic Regulatory Mechanisms.Adv Healthc Mater | Other paper | 2026 |
| Nicotinamide Adenine Dinucleotide Augmentation in Diabetic Kidney Disease: Randomized Trial Study Protocol.Kidney Int Rep | Other paper | 2026 |
| Enhancing the anti-ageing capacity of hUC-MSCs via NMN co-treatment in D-galactose-induced ageing mice and cellular senescence models.Mech Ageing Dev | Other paper | 2026 |
| PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticals.Geroscience | Other paper | 2026 |
| NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells.Autophagy | Other paper | 2026 |
| A potential anti-aging probiotic: Lactobacillus paracasei JS-3 extends lifespan in Caenorhabditis elegans and modulates the gut microbiota in the elderly.J Nutr Biochem | Other paper | 2026 |
| Bioactive chitosaan-nicotinamide mononucleotide-naringin composite scaffolds for enhanced maxillofacial bone regeneration.J Biomater Appl | Other paper | 2026 |
| Enhanced Sensitivity and Human Relevance: a TNF-α-Induced HaCaT Keratinocyte Model for Screening Anti-Inflammatory Cosmetic Materials.J Appl Toxicol | Other paper | 2026 |
| OsEPSPS Balances Disease Resistance and Plant Growth.Plant Cell Environ | Other paper | 2026 |
| Regulation-Metabolism Rewiring Enables Efficient Nicotinamide Mononucleotide Biosynthesis in Food-Grade Lactiplantibacillus plantarum.J Agric Food Chem | Other paper | 2026 |
| β-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells.J Aging Res | Other paper | 2026 |
| Endothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.Sci Adv | Other paper | 2026 |
| NMN mitigates LPS-induced liver injury by inhibiting ferroptosis via suppression of the cGAS-STING-ACSL4 axis.Pharmacol Res | Other paper | 2026 |
| Reprogramming the Rossmann fold signature motif creates orthogonal redox biocatalysts.Nat Commun | Other paper | 2026 |
| Engineered mesenchymal stem cells regulate integrated stress response for fibrosis therapy.Med | Other paper | 2026 |
| A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes.Nat Chem Biol | Other paper | 2026 |
| NAD+ metabolism influences TGF-β-associated transcriptional programs and the gut microbiota in murine models of colitis.Biochem Biophys Rep | Other paper | 2026 |
| Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2) - Related Polyneuropathy - An Unusual Symptom, and a Rare Disease.Neurol India | Other paper | 2026 |
| Nicotinamide mononucleotide potentiates the anti-tumor efficacy of CAR-NK cell therapy targeting MSLN in ovarian cancer.Cancer Gene Ther | Other paper | 2026 |
| Mitochondrial-impaired ductal epithelium fuels TLS formation in Sjögren's disease.Ann Rheum Dis | Other paper | 2026 |
| Metabolic Engineering of Pseudomonas putida KT2440 for β-Nicotinamide Mononucleotide Biosynthesis from Glucose and Aspartate.Microorganisms | Other paper | 2026 |
| A Staged Translational Framework for Evaluating Oral Glutamatergic and Senescence-Modulating Strategies in Treatment-Resistant Depression.Drug Des Devel Ther | Other paper | 2026 |
| Nicotinamide Mononucleotide (NMN) Prevents Age-Associated Transcriptional Drift in a Tissue-Dependent Manner: Mechanistic Leads From Ras-Related Protein Rab-11A-Mediated Trafficking and Carnitine Palmitoyltransferase 2-Linked Fatty Acid Oxidation.Cureus | Other paper | 2026 |
| New mechanistic insight into SARM1 activation: TRIM32-mediated ubiquitination is a key lever that actuates SARM1's catalytic action, leading to axon degeneration and cell death.Front Neural Circuits | Other paper | 2026 |
| A minimal three-arm oral regimen for healthspan: mechanistic alignment with transcriptomic signals from a large parental-lifespan GWAS.Front Aging | Other paper | 2026 |
| Nicotinamide Adenine Dinucleotide and Its Anti-aging Effects in the Context of Longevity and Menopause.Mini Rev Med Chem | Other paper | 2026 |
| Phage-encoded NARP3 system rebuilds NAD+ to subvert bacterial immunity.Sci Adv | Other paper | 2026 |
| Membrane-camouflaged liposomes Co-delivering L-Arg and NMN for reprogramming macrophage nitric oxide metabolism in atherosclerosis.J Biomater Appl | Other paper | 2026 |
| Senescence-associated metabolic alterations aggravate calcific aortic valve disease.Eur Heart J | Other paper | 2026 |
| Polycomb-Focused Transcriptome-Wide Association Study (TWAS) Reveals a Neuronal Identity, Circuit-Maintenance, and Cellular-Logistics Architecture Linking Anorexia Nervosa and Binge-Eating Behaviour.Cureus | Other paper | 2026 |
| The impact of nicotinamide mononucleotide on ovarian health: A comprehensive literature review of preclinical evidence and therapeutic potential.Clin Exp Reprod Med | Other paper | 2026 |
| Nicotinamide Mononucleotide Attenuates Inflammatory Activation, Choroidal Neovascularization, and Lesion-Associated Remodeling.Invest Ophthalmol Vis Sci | Other paper | 2026 |
| A combined artificial intelligence-wet lab approach identifies a pivotal role of the NAD+-mitophagy axis on aging and neurodegeneration.Alzheimers Dement | Other paper | 2026 |
| SIRT1 deacetylates PKM2 to constrain lactate production and protect against premature ovarian insufficiency.Life Med | Other paper | 2026 |
| AIE-pharmacology: Acacetin and NMN co-delivery rescues sperm motility.Mater Today Bio | Other paper | 2026 |
| Cellular Logistics and Synaptic Vesicle Vulnerability in Major Depressive Disorder and Amyotrophic Lateral Sclerosis Comorbidity: Insights From Nicotinamide Mononucleotide Rescue and Transcriptome-Wide Association Study Integration.Cureus | Other paper | 2026 |
| NMN alleviates oxidative stress damage in alopecia areata by activating SIRT7 and promoting glutamine metabolism.Biochim Biophys Acta Gene Regul Mech | Other paper | 2026 |
| Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.Cureus | Other paper | 2026 |
| Dual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours.Nat Commun | Other paper | 2026 |
| CPT2 as a Convergent Node Linking Age-Associated Neuronal H3K27me3 Remodeling to Nicotinamide Mononucleotide (NMN)-Induced Expression Rescue in Metabolic Tissues.Cureus | Other paper | 2026 |