A very short peptide studied in cells and animals for inflammation. No studies with random groups and no such medicine. We have not graded the studies yet. The number of papers in the databases is shown on the page.

PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. No approved medicine. On 30 October 2026 the US health department (HHS) published a draft policy: it does not plan to act against pharmacies and doctors that make it on a prescription for a named patient, from an FDA-registered maker, until the FDA decides by rule. The draft is not binding, and comments close on 13 November 2026.

Short entry. It holds facts from official registers, with no study grade. We are still writing the full description.

KPV

Lys-Pro-Val · alpha-MSH 11-13

A very short peptide studied in cells and animals for inflammation. No studies with random groups and no such medicine.

This site is for information and education only. It does not promote or encourage the use or purchase of the substances described and is not medical advice. Many are not authorised as medicines and their safety has not been established. We sell nothing and have no ties to sellers. For health decisions, consult a doctor.

Type: Peptide
Stage: Lab and animals only
Safety: Not known
Doping: May be banned, WADA 2026
Risk of fakes: Medium
Checked: Not yet

Doping. It is not on the WADA list, but WADA also bans substances that no health authority has approved, so it may be banned.

Safety. A 2026 review names it among peptides promoted in sport with little proof in people. Sources: study 1.

Risk of fakes. Reviews name it among peptides sold outside medical care. We found no tests of what these products contain. Sources: study 1.

Is it legal

Where	Status		Checked
PL	No approval	The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. Source	Not yet
EU	No approval	The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). Source	Not yet
US	No approval	No approved medicine. On 30 October 2026 the US health department (HHS) published a draft policy: it does not plan to act against pharmacies and doctors that make it on a prescription for a named patient, from an FDA-registered maker, until the FDA decides by rule. The draft is not binding, and comments close on 13 November 2026. Source	Not yet

How much research exists

Scientific papers: 46
Studies with random groups: 0
Registered studies in people: 0

Scientific papers per year 2015–2025

These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

Reported side effects

What doctors, patients and companies reported to the US medicines agency (FDA), and single cases described in medical journals. A report says what happened to someone after taking the substance. It does not prove the substance caused it, and it does not say how often it happens. Reports do not change any grade.

Reports to the FDA (USA)

Reports: 0
Of these, serious: 0

The FDA has no reports. That is not a sign of safety: almost nobody reports substances from outside pharmacies.

Cases described in medical journals

We found no published case of harm.

FDA reports come from openFDA, cases from a PubMed search. The editors have not read these cases yet. Titles stay in the original language. As of 3 Nov 2026.

More papers we found

Studies	Kind of study	Year
Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.Drug Discov Today	Review of studies	2025
The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials.Cells	Review of studies	2023
Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore.Adv Exp Med Biol	Review of studies	2010
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.Endocr Rev	Review of studies	2008
New insights into the functions of alpha-MSH and related peptides in the immune system.Ann N Y Acad Sci	Review of studies	2003
The neuropeptide alpha-MSH in host defense.Ann N Y Acad Sci	Review of studies	2000
The neuroimmunomodulatory peptide alpha-MSH.Ann N Y Acad Sci	Review of studies	2000
Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers.ACS Appl Mater Interfaces	In animals	2024

We found these papers automatically in PubMed. The editors have not read them yet, and they do not affect any grade. Titles stay in the original language.

All papers and studies we found (45)

Short answers

Does KPV work?: A very short peptide studied in cells and animals for inflammation. No studies with random groups and no such medicine. We have not graded the studies yet. The number of papers in the databases is shown on the page.
Is KPV legal?: PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. No approved medicine. On 30 October 2026 the US health department (HHS) published a draft policy: it does not plan to act against pharmacies and doctors that make it on a prescription for a named patient, from an FDA-registered maker, until the FDA decides by rule. The draft is not binding, and comments close on 13 November 2026.
Is KPV banned in sport?: May be banned, WADA 2026. It is not on the WADA list, but WADA also bans substances that no health authority has approved, so it may be banned.
Is KPV safe?: Not known. A 2026 review names it among peptides promoted in sport with little proof in people.

Plain text for machines

Change history

30 Oct 2026Legal
The US health department published a draft policy under which it would not act against pharmacies that make KPV on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
kpv Source 1 Source 2