PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: Approved medicine. No EU-wide approval. Aviptadil with phentolamine (Invicorp, Corpin) is approved in Denmark, Finland, France, Germany, Norway and Sweden (European medicines database, EMA, 9 October 2026). VIP alone is not. US: No approval. The FDA drug register has no such medicine.

Short entry. It holds facts from official registers, with no study grade. We are still writing the full description.

VIP

vasoactive intestinal peptide · aviptadil

A natural peptide that acts on blood vessels and the gut. Studied in lung disease. With phentolamine it is a licensed injection for erection problems in some European countries. Not in the US register.

This site is for information and education only. It does not promote or encourage the use or purchase of the substances described and is not medical advice. Many are not authorised as medicines and their safety has not been established. We sell nothing and have no ties to sellers. For health decisions, consult a doctor.

Type: Hormone
Stage: Still being studied
Safety: Little data
Doping: Not on the list, WADA 2026
Risk of fakes: Not known
Checked: Not yet

Safety. Studied as a drip in very ill COVID-19 patients and as an injection for erection problems. That does not describe any other use. Sources: study 1, study 2.

Risk of fakes. We found no tests of products sold outside pharmacies.

Is it legal

Where	Status		Checked
PL	No approval	The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. Source	Not yet
EU	Approved medicine	No EU-wide approval. Aviptadil with phentolamine (Invicorp, Corpin) is approved in Denmark, Finland, France, Germany, Norway and Sweden (European medicines database, EMA, 9 October 2026). VIP alone is not. Source	Not yet
US	No approval	The FDA drug register has no such medicine. Source	Not yet

How much research exists

Scientific papers: 627
Studies with random groups: 11
Registered studies in people: 23

Scientific papers per year 2015–2025

These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

Reported side effects

What doctors, patients and companies reported to the US medicines agency (FDA), and single cases described in medical journals. A report says what happened to someone after taking the substance. It does not prove the substance caused it, and it does not say how often it happens. Reports do not change any grade.

Reports to the FDA (USA)

Reports: 27
Of these, serious: 26

Most often reported	Reports
Sudden severe belly pain	7
Ketoacidosis with normal blood sugar	6
Vomiting	6
Fainting	5
Flushing	3
Pain	3
Miscarriage	2
Sudden kidney damage	1

Serious means the person went to hospital, their life was in danger, they were left with lasting harm, or they died. One report can list several side effects.

Cases described in medical journals

Intractable and dramatic diarrhea in liver transplantation recipient with vasoactive intestinal peptide-producing tumor after split liver transplantation: a case report.Transplant Proc 2015

All cases in PubMed (2)

FDA reports come from openFDA, cases from a PubMed search. The editors have not read these cases yet. Titles stay in the original language. As of 3 Nov 2026.

More papers we found

Studies	Kind of study	Year
Inhaled Aviptadil Is a New Hope for Recovery of Lung Damage due to COVID-19.Med Princ Pract	Random groups	2025
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.Lancet Respir Med	Random groups	2023
Effect of intracanal medicaments on matrix metalloproteinase-9 and vasoactive intestinal peptide secretion in periapical lesions of re-treated canals: a randomized controlled clinical study.Clin Oral Investig	Random groups	2019
Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome.J Tradit Chin Med	Random groups	2015
[Effects of electroacupuncture on plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients].Zhen Ci Yan Jiu	Random groups	2007
Effect of acupuncture on vasoactive intestinal peptide in ischemic cerebrovascular diseases.J Tradit Chin Med	Random groups	1997
[The changes of vasoactive intestinal peptide somatostatin and pancreatic polypeptide in blood and CSF of acute cerebral infarction patients and the effect of acupuncture on them].Zhen Ci Yan Jiu	Random groups	1996
A clinical trial of intracavernous vasoactive intestinal peptide to induce penile erection.J Urol	Random groups	1990

We found these papers automatically in PubMed. The editors have not read them yet, and they do not affect any grade. Titles stay in the original language.

All papers and studies we found (232)

Short answers

Does VIP work?: A natural peptide that acts on blood vessels and the gut. Studied in lung disease. With phentolamine it is a licensed injection for erection problems in some European countries. Not in the US register. We have not graded the studies yet. The number of papers in the databases is shown on the page.
Is VIP legal?: PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: Approved medicine. No EU-wide approval. Aviptadil with phentolamine (Invicorp, Corpin) is approved in Denmark, Finland, France, Germany, Norway and Sweden (European medicines database, EMA, 9 October 2026). VIP alone is not. US: No approval. The FDA drug register has no such medicine.
Is VIP banned in sport?: Not on the list, WADA 2026.
Is VIP safe?: Little data. Studied as a drip in very ill COVID-19 patients and as an injection for erection problems. That does not describe any other use.

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