Graded
The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
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Somatropin

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Scientific papers

StudiesKind of studyYear
Effects of Recombinant Human Growth Hormone for Osteoporosis: Systematic Review and Meta-Analysis.Can J AgingPooled analysis2017
The effect of growth hormone (GH) replacement on muscle strength in patients with GH-deficiency: a meta-analysis.Clin Endocrinol (Oxf)Pooled analysis2010
Systematic review: the safety and efficacy of growth hormone in the healthy elderly.Ann Intern MedPooled analysis2007
Does exogenous growth hormone improve athletic performance?Clin J Sport MedPooled analysis2002
Recombinant human growth hormone (rHGH) for muscle enhancement in knee osteoarthritis: protocol for a pilot, randomised placebo-controlled trial.BMJ OpenRandom groups2026
Growth Hormone Replacement Therapy in Heart Failure With Reduced Ejection Fraction: A Randomized, Double-Blind, Placebo-Controlled Trial.JACC Heart FailRandom groups2025
Application of the Athlete Biological Passport Approach to the Detection of Growth Hormone Doping.J Clin Endocrinol MetabRandom groups2022
The Use of Recombinant Human Growth Hormone to Protect Against Muscle Weakness in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Pilot, Randomized Placebo-Controlled Trial.Am J Sports MedRandom groups2020
Growth Hormone (GH) Improvement of Ovarian Responses and Pregnancy Outcome in Poor Ovarian Responders: A Randomized Study.Asian Pac J Cancer PrevRandom groups2019
Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes.Fertil SterilRandom groups2018
Decorin, a growth hormone-regulated protein in humans.Eur J EndocrinolRandom groups2018
Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women.Physiol RepRandom groups2017
Plasma biomarker proteins for detection of human growth hormone administration in athletes.Sci RepRandom groups2017
Growth hormone therapy, muscle thickness, and motor development in Prader-Willi syndrome: an RCT.PediatricsRandom groups2014
The influence of age and exercise modality on growth hormone bioactivity in women.Growth Horm IGF ResRandom groups2014
Somatropin treatment of spinal muscular atrophy: a placebo-controlled, double-blind crossover pilot study.Neuromuscul DisordRandom groups2014
Effect of growth hormone on aging connective tissue in muscle and tendon: gene expression, morphology, and function following immobilization and rehabilitation.J Appl Physiol (1985)Random groups2014
Effects of growth hormone and testosterone therapy on aerobic and anaerobic fitness, body composition and lipoprotein profile in middle-aged men.Ann Agric Environ MedRandom groups2014
Tendon and skeletal muscle matrix gene expression and functional responses to immobilisation and rehabilitation in young males: effect of growth hormone administration.J PhysiolRandom groups2013
Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging.JAMA NeurolRandom groups2013
Effects of recombinant human growth hormone for 1 year on body composition and muscle strength in children on long-term steroid therapy: randomized controlled, delayed-start study.J Clin Endocrinol MetabRandom groups2013
The effects of two weeks of recombinant growth hormone administration on the response of IGF-I and N-terminal pro-peptide of collagen type III (P-III-NP) during a single bout of high resistance exercise in resistance trained young men.Growth Horm IGF ResRandom groups2013
Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.Arch NeurolRandom groups2012
Tracking growth hormone abuse in sport: a comparison of distinct isoform-based assays.Anal Chim ActaRandom groups2012
Value of measuring muscle performance to assess changes in lean mass with testosterone and growth hormone supplementation.Eur J Appl PhysiolRandom groups2012
Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women.J Nutr Health AgingRandom groups2012
Novel serum protein biomarkers indicative of growth hormone doping in healthy human subjects.ProteomicsRandom groups2011
The effects of short term recombinant human growth hormone (rhGH) on blood rheology in healthy young males.Clin Hemorheol MicrocircRandom groups2011
Effects of short term growth hormone therapy in adult growth hormone deficiency.J Assoc Physicians IndiaRandom groups2010
Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.J Strength Cond ResRandom groups2010
Detection of growth hormone doping by gene expression profiling of peripheral blood.J Clin Endocrinol MetabRandom groups2009
Growth hormone and sex steroid effects on serum glucose, insulin, and lipid concentrations in healthy older women and men.J Clin Endocrinol MetabRandom groups2009
Detecting growth hormone abuse in athletes.Drug Test AnalRandom groups2009
Proteomic profiling of growth hormone-responsive proteins in human peripheral blood leukocytes.J Clin Endocrinol MetabRandom groups2009
Testosterone and growth hormone improve body composition and muscle performance in older men.J Clin Endocrinol MetabRandom groups2009
Effects of an oral growth hormone secretagogue in older adults.J Clin Endocrinol MetabRandom groups2009
Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease.J Alzheimers DisRandom groups2009
The effects of growth hormone and/or testosterone on whole body protein kinetics and skeletal muscle gene expression in healthy elderly men: a randomized controlled trial.J Clin Endocrinol MetabRandom groups2008
Pharmacodynamics of growth hormone abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes.J Clin Endocrinol MetabRandom groups2008
Short-term recombinant human growth hormone administration improves respiratory function in abstinent anabolic-androgenic steroid users.Growth Horm IGF ResRandom groups2007
Increased serum concentration of IGFBP-4 and IGFBP-5 in healthy adults during one month's treatment with supraphysiological doses of growth hormone.Growth Horm IGF ResRandom groups2007
Detection of growth hormone abuse in sport.Growth Horm IGF ResRandom groups2007
Two years of growth hormone therapy in young children with Prader-Willi syndrome: physical and neurodevelopmental benefits.Am J Med Genet ARandom groups2007
The ghrelin response to exercise before and after growth hormone administration.J Clin Endocrinol MetabRandom groups2007
Sleep-related breathing disorders in prepubertal children with Prader-Willi syndrome and effects of growth hormone treatment.J Clin Endocrinol MetabRandom groups2006
Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men.J Clin Endocrinol MetabRandom groups2006
Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients.Ann SurgRandom groups2006
The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial.J Clin Endocrinol MetabRandom groups2006
Novel biomarkers of human growth hormone action from serum proteomic profiling using protein chip mass spectrometry.J Clin Endocrinol MetabRandom groups2006
Effects of high-dose growth hormone on glucose and glycerol metabolism at rest and during exercise in endurance-trained athletes.J Clin Endocrinol MetabRandom groups2006
Effects of growth hormone and/or sex steroid administration on whole-body protein turnover in healthy aged women and men.MetabolismRandom groups2005
Limited efficacy of growth hormone (GH) during transition of GH-deficient patients from adolescence to adulthood: a phase III multicenter, double-blind, randomized two-year trial.J Clin Endocrinol MetabRandom groups2005
Joint mechanisms of impaired growth-hormone pulse renewal in aging men.J Clin Endocrinol MetabRandom groups2005
Short-term administration of supraphysiological recombinant human growth hormone (GH) does not increase maximum endurance exercise capacity in healthy, active young men and women with normal GH-insulin-like growth factor I axes.J Clin Endocrinol MetabRandom groups2005
Supraphysiological growth hormone: less fat, more extracellular fluid but uncertain effects on muscles in healthy, active young adults.Clin Endocrinol (Oxf)Random groups2005
Sustained growth hormone (GH) and insulin-like growth factor I responses to prolonged high-dose twice-daily GH-releasing hormone stimulation in middle-aged and older men.J Clin Endocrinol MetabRandom groups2004
Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth hormone secretion in healthy middle-aged and older adults.J Clin Endocrinol MetabRandom groups2004
Age and secretagogue type jointly determine dynamic growth hormone responses to exogenous insulin-like growth factor-negative feedback in healthy men.J Clin Endocrinol MetabRandom groups2004
Frailty and the biochemical effects of recombinant human growth hormone in women after surgery for hip fracture.Growth Horm IGF ResRandom groups2003
Growth hormone (GH) dose-response in young adults with childhood-onset GH deficiency: a two-year, multicenter, multiple-dose, placebo-controlled study.J Clin Endocrinol MetabRandom groups2003
High dose growth hormone exerts an anabolic effect at rest and during exercise in endurance-trained athletes.J Clin Endocrinol MetabRandom groups2003
Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns.J Appl Physiol (1985)Random groups2003
The insulin-like growth factor-I generation test: peripheral responsiveness to growth hormone is not decreased with ageing.Clin Endocrinol (Oxf)Random groups2003
The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men.Horm ResRandom groups2003
Recombinant human growth hormone treatment in elderly patients undergoing elective total hip replacement.Clin Endocrinol (Oxf)Random groups2003
Effects of ginseng ingestion on growth hormone, testosterone, cortisol, and insulin-like growth factor 1 responses to acute resistance exercise.J Strength Cond ResRandom groups2002
Effect of growth hormone on exercise tolerance in children with cystic fibrosis.Med Sci Sports ExercRandom groups2002
The behavioral impact of growth hormone treatment for children and adolescents with Prader-Willi syndrome: a 2-year, controlled study.PediatricsRandom groups2002
Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men.J Gerontol A Biol Sci Med SciRandom groups2002
Growth hormone improves clinical status in prepubertal children with cystic fibrosis: results of a randomized controlled trial.J PediatrRandom groups2001
Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people.J Am Geriatr SocRandom groups2001
A randomized controlled trial of low-dose recombinant human growth hormone in the treatment of malnourished elderly medical patients.J Clin Endocrinol MetabRandom groups2001
Changes in non-22-kilodalton (kDa) isoforms of growth hormone (GH) after administration of 22-kDa recombinant human GH in trained adult males.J Clin Endocrinol MetabRandom groups2001
Role of body temperature in exercise-induced growth hormone and prolactin release in non-trained and physically fit subjects.Endocr RegulRandom groups2000
Reduction of free fatty acids by acipimox enhances the growth hormone (GH) responses to GH-releasing peptide 2 in elderly men.J Clin Endocrinol MetabRandom groups2000
Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women.J Clin Endocrinol MetabRandom groups2000
Growth hormone (GH) effects on bone and collagen turnover in healthy adults and its potential as a marker of GH abuse in sports: a double blind, placebo-controlled study. The GH-2000 Study Group.J Clin Endocrinol MetabRandom groups2000
Responses of markers of bone and collagen turnover to exercise, growth hormone (GH) administration, and GH withdrawal in trained adult males.J Clin Endocrinol MetabRandom groups2000
Physical effects of growth hormone treatment in children with Prader-Willi syndrome.Acta Paediatr SupplRandom groups1999
Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults.J Clin Endocrinol MetabRandom groups1999
Synthetic somatostatin analog (octreotide) suppresses daytime growth hormone secretion equivalently in young and older men: preserved pituitary responsiveness to somatostatin's inhibition in aging.J Am Geriatr SocRandom groups1999
Effects of growth hormone replacement on physical performance and body composition in GH deficient adults.Clin Endocrinol (Oxf)Random groups1999
Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults. A placebo-controlled trial.Arq NeuropsiquiatrRandom groups1999
Increased serum levels of growth hormone and insulin-like growth factor-I associated with simultaneous decrease of circulating insulin in postmenopausal women receiving hormone replacement therapy.MenopauseRandom groups1999
Perioperative growth hormone treatment and functional outcome after major abdominal surgery: a randomized, double-blind, controlled study.Ann SurgRandom groups1999
Growth hormone improves body composition, fat utilization, physical strength and agility, and growth in Prader-Willi syndrome: A controlled study.J PediatrRandom groups1999
Strength and its relationship to changes in fat-free mass, total body potassium, total body water and IGF-1 in adults with growth hormone deficiency: effect of treatment with growth hormone.Ann Hum BiolRandom groups1999
Effect of low-dosage recombinant human growth hormone therapy on pulmonary function in hypopituitary patients with adult-onset growth hormone deficiency.J Endocrinol InvestRandom groups1998
Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men.Eur J EndocrinolRandom groups1998
Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women.J Clin Endocrinol MetabRandom groups1998
Growth hormone secretagogues: mechanism of action and use in aging.Growth Horm IGF ResRandom groups1998
Administration of growth hormone to underweight patients with chronic obstructive pulmonary disease. A prospective, randomized, controlled study.Am J Respir Crit Care MedRandom groups1997
Effects of growth hormone treatment on growth and body composition in Prader-Willi syndrome: a preliminary report. The Swedish National Growth Hormone Advisory Group.Acta Paediatr SupplRandom groups1997
Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women.J Clin Endocrinol MetabRandom groups1997
Quality of life, body composition and muscle strength in adult growth hormone deficiency: the influence of growth hormone replacement therapy for up to 3 years.Clin Endocrinol (Oxf)Random groups1997
Effect of resistance exercise and growth hormone on bone density in older men.Clin Endocrinol (Oxf)Random groups1997
Leucine supplementation and serum amino acids, testosterone, cortisol and growth hormone in male power athletes during training.J Sports Med Phys FitnessRandom groups1997
Growth hormone versus placebo treatment for one year in growth hormone deficient adults: increase in exercise capacity and normalization of body composition.Clin Endocrinol (Oxf)Random groups1996
Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting. A randomized, double-blind, placebo-controlled trial.Ann Intern MedRandom groups1996
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.J Clin Endocrinol MetabRandom groups1996
A randomized, placebo-controlled trial of combined insulin-like growth factor I and low dose growth hormone therapy for wasting associated with human immunodeficiency virus infection.J Clin Endocrinol MetabRandom groups1996
Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.J Clin Endocrinol MetabRandom groups1996
Lack of effects of recombinant growth hormone on muscle function in patients requiring prolonged mechanical ventilation: a prospective, randomized, controlled study.Crit Care MedRandom groups1996
Resistance exercise and growth hormone administration in older men: effects on insulin sensitivity and secretion during a stable-label intravenous glucose tolerance test.MetabolismRandom groups1996
Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men.J Clin Endocrinol MetabRandom groups1996
Effect of growth hormone and resistance exercise on muscle growth and strength in older men.Am J PhysiolRandom groups1995
Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood.J Clin Endocrinol MetabRandom groups1995
Replacement treatment with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults.Clin Endocrinol (Oxf)Random groups1995
Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects.J Clin Endocrinol MetabRandom groups1994
Regional fat distribution by dual-energy X-ray absorptiometry: comparison with anthropometry and application in a clinical trial of growth hormone and exercise.Clin Sci (Lond)Random groups1994
Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.J Clin Endocrinol MetabRandom groups1994
Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects.J Clin Endocrinol MetabRandom groups1994
Effect of a sustained program of resistance training on the acute growth hormone response to resistance exercise in older adults.Horm Metab ResRandom groups1994
Growth hormone enhances amino acid uptake by the human small intestine.Ann SurgRandom groups1994
Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance.Eur J EndocrinolRandom groups1994
Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.J Clin Endocrinol MetabRandom groups1992
Effect of growth hormone and resistance exercise on muscle growth in young men.Am J PhysiolRandom groups1992
Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study.Clin Endocrinol (Oxf)Random groups1992
Role of aging on growth hormone and prolactin release after growth hormone-releasing hormone and domperidone in man.Horm ResRandom groups1987
Predictors of Insulin-Like Growth Factor-I Responses to Growth Hormone Replacement in Young Adults with Growth Hormone Deficiency.Horm Res PaediatrNo random groups2016
Low-dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults.Growth Horm IGF ResNo random groups2008
Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage.J Appl Physiol (1985)No random groups2008
Tripartite control of growth hormone secretion in women during controlled estradiol repletion.J Clin Endocrinol MetabNo random groups2007
A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults.J Clin Endocrinol MetabNo random groups2007
Growth hormone releasing hormone improves the cognition of healthy older adults.Neurobiol AgingNo random groups2006
The effects of five-year growth hormone replacement therapy on muscle strength in elderly hypopituitary patients.Clin Endocrinol (Oxf)No random groups2005
Physiological testosterone replenishment in healthy elderly men does not normalize pituitary growth hormone output: evidence against the connection between senile hypogonadism and somatopause.J Clin Endocrinol MetabNo random groups2004
Growth hormone substitution titrated to obtain IGF-I levels in the physiological range in hypopituitary adults: effects upon dynamic strength, endurance and EMG.Eur J Appl PhysiolNo random groups2003
Influence of muscle strength and total work on exercise-induced plasma growth hormone isoforms in women.J Sci Med SportNo random groups2003
Growth hormone, somatomedins and men's health.Aging MaleNo random groups2002
Effect of low-dose of recombinant human growth hormone on bone metabolism in elderly women with osteoporosis.Eur J EndocrinolNo random groups2002
Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: differential effects on protein, glucose, lipid, and calcium metabolism.J Clin Endocrinol MetabNo random groups2000
Growth hormone responses to continuous and intermittent exercise in females under oral contraceptive therapy.Eur J Appl Physiol Occup PhysiolNo random groups1998
[The effect of growth hormone replacement therapy on markers of bone formation and bone mineral density in elderly men].Pol Arch Med WewnNo random groups1998
Growth hormone improves weight velocity and height velocity in prepubertal children with cystic fibrosis.Horm Metab ResNo random groups1998
Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.NeuroendocrinologyNo random groups1997
Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly.Neurobiol AgingNo random groups1997
Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults.J Clin Endocrinol MetabNo random groups1997
Longtime administration of growth hormone-releasing hormone (GHRH) does not restore the reduced efficiency of GHRH on sleep endocrine activity in 2 old-aged subjects--a preliminary study.PharmacopsychiatryNo random groups1997
Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.MetabolismNo random groups1997
Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging.Eur J EndocrinolNo random groups1996
Use of growth hormone for postoperative respiratory failure.Am J SurgNo random groups1996
Testosterone, growth hormone and IGF-I responses to acute and chronic resistive exercise in men aged 55-70 years.Int J Sports MedNo random groups1995
Serum testosterone and growth hormone/insulin-like growth factor-I in adults with spinal cord injury.Horm Metab ResNo random groups1995
Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging.Eur J EndocrinolNo random groups1994
Growth hormone (GH) treatment in GH-deficient adults: effects on muscle size, strength and neural activation.Clin PhysiolNo random groups1994
Growth hormone and insulin-like growth factor I in athletes performing a marathon at 4000 m of altitude.Growth RegulNo random groups1994
Arginine enhances the growth hormone-releasing activity of a synthetic hexapeptide (GHRP-6) in elderly but not in young subjects after oral administration.J Endocrinol InvestNo random groups1994
Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects.J Endocrinol InvestNo random groups1994
Oral arginine-lysine does not increase growth hormone or insulin-like growth factor-I in old men.J GerontolNo random groups1993
Effect of growth hormone treatment on hormonal parameters, body composition and strength in athletes.Acta Endocrinol (Copenh)No random groups1993
The effect of a met-enkephalin analogue on growth hormone, prolactin, gonadotropins, cortisol and thyroid stimulating hormone in healthy elderly men.Acta Endocrinol (Copenh)No random groups1992
Growth hormone secretion in aging. Effect of pyridostigmine on growth hormone responsiveness to growth hormone-releasing hormone.Recenti Prog MedNo random groups1991
Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency.Acta Endocrinol (Copenh)No random groups1990
Repetitive growth hormone-releasing hormone administration restores the attenuated growth hormone (GH) response to GH-releasing hormone testing in normal aging.J Clin Endocrinol MetabNo random groups1989
Impaired growth hormone response to sodium valproate in normal aging.Psychopharmacology (Berl)No random groups1987
Metabolic and muscular effects of switching from somatropin to somapacitan in adults with growth hormone deficiency.J Clin Endocrinol MetabGroup followed over time2026
Positive effect of growth hormone treatment in maternal uniparental disomy chromosome 14.Clin Endocrinol (Oxf)Group followed over time2015
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.Front SurgCase reports2026
Case Report: Efficacy and safety of recombinant growth hormone therapy in a girl with Loeys-Dietz syndrome.Front Cardiovasc MedCase reports2024
Little League Shoulder and Subsequent Proximal Humeral Fracture in the Setting of Human Growth Hormone Use: A Case Report.JBJS Case ConnectCase reports2023
Fatal overdose from injection of human growth hormone; a case report and review of the literature.BMC Endocr DisordCase reports2022
Isoflurane Induced Malignant Hyperthermia in a Patient with Glucose 6-Phosphate Dehydrogenase Deficiency and Growth Hormone Abuse.Case Rep AnesthesiolCase reports2020
Growth hormone deficiency with late-onset hypothalamic hypoadrenocorticism associated with respiratory and renal dysfunction: a case report.BMC Endocr DisordCase reports2020
Sternoclavicular Joint Septic Arthritis and Anterior Mediastinal Mass in a Young Athlete: Possible Immune-modulatory Effect of Growth Hormone.CureusCase reports2019
Short stature in a boy with atypical progeria syndrome due to LMNA c.433G>A [p.(Glu145Lys)]: apparent growth hormone deficiency but poor response to growth hormone therapy.J Pediatr Endocrinol MetabCase reports2019
Growth Hormone and ACTH Deficiency in a Diabetic Adult.J Coll Physicians Surg PakCase reports2019
The potential effects of anabolic-androgenic steroids and growth hormone as commonly used sport supplements on the kidney: a systematic review.BMC NephrolCase reports2019
Human growth hormone stabilizes walking and improves strength in a patient with dominantly inherited calpainopathy.Neuromuscul DisordCase reports2017
Agenesis of internal carotid artery associated with isolated growth hormone deficiency: a case report and literature review.BMC Endocr DisordCase reports2015
Growth hormone deficiency in a patient with mitochondrial disease.J Pediatr Endocrinol MetabCase reports2015
New onset diabetes associated with bovine growth hormone and testosterone abuse in a young body builder.Hum Exp ToxicolCase reports2011
Respiratory failure was improved by growth hormone substitution in a patient with hypopituitarism.BMJ Case RepCase reports2010
Effect of recombinant growth hormone replacement in a growth hormone deficient subject recovering from mild traumatic brain injury: A case report.Brain InjCase reports2010
Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis.Clin Gastroenterol HepatolCase reports2008
Growth hormone therapy in progeria.J Pediatr Endocrinol MetabCase reports2007
Growth hormone and insulin-like growth factor I in a Sydney Olympic gold medallist.Br J Sports MedCase reports2002
Effective growth hormone therapy in a growth hormone deficient patient with Duchenne muscular dystropy without evidence of acceleration of the dystrophic process.J Pediatr Endocrinol MetabCase reports2001
Bilateral median neuropathy and growth hormone use: a case report.Arch Phys Med RehabilCase reports2000
Clinical and reimbursement issues in growth hormone use in adults.Am J Manag CareCase reports2000
The regulatory effects of growth hormone on adipose tissue at physiological and pathological levels and its relationship with obesity.Int J Obes (Lond)Review of studies2026
Treatment of growth hormone deficiency with long-acting growth hormones in children, adolescents and adults: Clinical evidence and practical considerations.Ann Endocrinol (Paris)Review of studies2026
[Growth hormone and fertility: molecular mechanisms and experience of adjuvant therapy in reproductology].Probl Endokrinol (Mosk)Review of studies2026
Growth Hormone and Brain Regeneration: Evidence from Clinical Studies in Dementia, Traumatic Brain Injury, and Stroke: A Systematic Review.Int J Mol SciReview of studies2026
Endocrine-informed monitoring of scoliosis in Prader-Willi syndrome: integrating neuroendocrine pathophysiology, growth hormone therapy, and pubertal transition.Front Endocrinol (Lausanne)Review of studies2026
Human Growth Hormone as a Therapeutic Treatment Option in Orthopaedics: A Systematic Review of Dosing, Side Effects, and Clinical Outcomes.JBJS RevReview of studies2026
Growth hormone treatment in adults with Prader-Willi syndrome: an update.Expert Rev Endocrinol MetabReview of studies2025
Growth hormone deficiency in Cushing's syndrome: an update on diagnosis and management.Expert Rev Endocrinol MetabReview of studies2025
The Role of Growth Hormone-Releasing Hormone and the Hypothalamic-Pituitary-Somatotropic Axis in Aging: Potential Therapeutic Applications and Risks.Horm Metab ResReview of studies2025
Biological effects of recombinant human growth hormone therapy on metabolism in children with growth hormone deficiency: a review.J Pediatr Endocrinol MetabReview of studies2025
[Expert consensus on the treatment of aging related to growth hormone deficiency].Zhonghua Yi Xue Za ZhiReview of studies2025
The role of growth hormone in assisted reproductive technology for patients with diminished ovarian reserve: from signaling pathways to clinical applications.Front Endocrinol (Lausanne)Review of studies2025
Growth hormone and aging: a clinical review.Front AgingReview of studies2025
Growth Hormone, Hypothalamic Inflammation, and Aging.J Obes Metab SyndrReview of studies2024
Common and Uncommon Mouse Models of Growth Hormone Deficiency.Endocr RevReview of studies2024
Policy for transitioning childhood-onset growth hormone deficiency from pediatric to adult endocrine care in Belgium.Front Endocrinol (Lausanne)Review of studies2024
Growth hormone treatment in aged patients with comorbidities: A systematic review.Growth Horm IGF ResReview of studies2024
Growth Hormone and Aging.Endocrinol Metab Clin North AmReview of studies2023
Mechanisms of ageing: growth hormone, dietary restriction, and metformin.Lancet Diabetes EndocrinolReview of studies2023
Doping and sports endocrinology: growth hormone, IGF-1, insulin, and erythropoietin.Rev Clin Esp (Barc)Review of studies2023
Understanding the role of growth hormone in situations of metabolic stress.J EndocrinolReview of studies2023
Regulation of ovarian function by growth hormone: Potential intervention of ovarian aging.Front Endocrinol (Lausanne)Review of studies2022
Somapacitan: a long-acting growth hormone derivative for treatment of growth hormone deficiency.Drugs Today (Barc)Review of studies2022
Skeletal disorders associated with the growth hormone-insulin-like growth factor 1 axis.Nat Rev EndocrinolReview of studies2022
Procollagen type III amino-terminal propeptide and insulin-like growth factor I as biomarkers of growth hormone administration.Drug Test AnalReview of studies2022
Growth Hormone and Aging: New Findings.World J Mens HealthReview of studies2021
Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age.PituitaryReview of studies2021
Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers.Front Cell Dev BiolReview of studies2021
The Complex World of Regulation of Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It.Front Endocrinol (Lausanne)Review of studies2021
Mouse models of growth hormone insensitivity.Rev Endocr Metab DisordReview of studies2021
Mouse models of growth hormone deficiency.Rev Endocr Metab DisordReview of studies2021
Individual sensitivity to growth hormone replacement in adults.Rev Endocr Metab DisordReview of studies2021
Growth hormone and aging.Rev Endocr Metab DisordReview of studies2021
Links Between Testosterone, Oestrogen, and the Growth Hormone/Insulin-Like Growth Factor Axis and Resistance Exercise Muscle Adaptations.Front PhysiolReview of studies2020
Growth Hormone Receptor Regulation in Cancer and Chronic Diseases.Front Endocrinol (Lausanne)Review of studies2020
Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise.Front Endocrinol (Lausanne)Review of studies2020
Rhythmic growth hormone secretion in physiological and pathological conditions: Lessons from rodent studies.Mol Cell EndocrinolReview of studies2019
The enigmatic role of growth hormone in age-related diseases, cognition, and longevity.GeroscienceReview of studies2019
The promise of growth hormone in sport: doped or duped.Arch Endocrinol MetabReview of studies2019
[The physiological role of growth hormone and insulin-like growth factors].Orv HetilReview of studies2019
The Use and Abuse of Growth Hormone in Sports.Endocr RevReview of studies2019
Growth Hormone Deficiency: Health and Longevity.Endocr RevReview of studies2019
From White to Brown - Adipose Tissue Is Critical to the Extended Lifespan and Healthspan of Growth Hormone Mutant Mice.Adv Exp Med BiolReview of studies2019
Growth Hormone and Aging: Updated Review.World J Mens HealthReview of studies2019
Impact of Growth Hormone-Related Mutations on Mammalian Aging.Front GenetReview of studies2018
The Use and Abuse of Human Growth Hormone in Sports.Sports HealthReview of studies2018
MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?Eur J EndocrinolReview of studies2018
Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects.Mol Cell EndocrinolReview of studies2018
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.Front Endocrinol (Lausanne)Review of studies2018
The Safety and Efficacy of Growth Hormone Secretagogues.Sex Med RevReview of studies2018
Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging.Stem Cell Rev RepReview of studies2017
Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats.Arq NeuropsiquiatrReview of studies2017
The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.Clin ProteomicsReview of studies2017
Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.AdipocyteReview of studies2017
The Somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor-1 Axis in Immunoregulation and Immunosenescence.Front Horm ResReview of studies2017
The Longevity Hormone Klotho is a New Player in the Interacion of the Growth Hormone/Insulin-Like Growth Factor 1 Axis.Pediatr Endocrinol RevReview of studies2016
Healthspan and longevity can be extended by suppression of growth hormone signaling.Mamm GenomeReview of studies2016
Neuroendocrine Regulation of Growth Hormone Secretion.Compr PhysiolReview of studies2016
Growth Hormone and Insulin-Like Growth Factor-1.Front Horm ResReview of studies2016
Klotho and the Growth Hormone/Insulin-Like Growth Factor 1 Axis: Novel Insights into Complex Interactions.Vitam HormReview of studies2016
Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.Ann N Y Acad SciReview of studies2016
Growth hormone, insulin-like growth factor-1 and the aging brain.Exp GerontolReview of studies2015
Growth Hormone Therapy in Adults with Prader-Willi Syndrome.DiseasesReview of studies2015
Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention: do we really have an antiaging drug?Interdiscip Top GerontolReview of studies2015
Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency.DiabetologiaReview of studies2015
Can anabolic steroids or human growth hormone affect the growth and maturation of adolescent athletes?Pediatr Exerc SciReview of studies2014
[Benefits and risks of growth hormone in adults with growth hormone deficiency].Med Clin (Barc)Review of studies2014
Mass spectrometry - an alternative in growth hormone measurement.BioanalysisReview of studies2014
Protective actions of melatonin and growth hormone on the aged cardiovascular system.Horm Mol Biol Clin InvestigReview of studies2014
Growth hormone and Klotho.J EndocrinolReview of studies2013
Detecting growth hormone misuse in athletes.Indian J Endocrinol MetabReview of studies2013
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.Crit Rev Oncol HematolReview of studies2013
Growth hormone and growth?Gen Comp EndocrinolReview of studies2013
Growth hormone in the aging male.Best Pract Res Clin Endocrinol MetabReview of studies2013
Growth hormone axis and aging.Endocrinol Metab Clin North AmReview of studies2013
Idiopathic adult growth hormone deficiency.J Clin Endocrinol MetabReview of studies2013
Mouse models of growth hormone action and aging: a proteomic perspective.ProteomicsReview of studies2013
Links between growth hormone and aging.Endokrynol PolReview of studies2013
Effects of growth hormone on heart structure and function in adolescence.Georgian Med NewsReview of studies2012
Possible usefulness of growth hormone/insulin-like growth factor-I axis in Alzheimer's disease treatment.Endocr Metab Immune Disord Drug TargetsReview of studies2012
Growth hormone and the cardiovascular system.Cardiol RevReview of studies2012
Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.J Gerontol A Biol Sci Med SciReview of studies2012
Growth hormone doping in sports: a critical review of use and detection strategies.Endocr RevReview of studies2012
Mapping the growth hormone--Stat5b--IGF-I transcriptional circuit.Trends Endocrinol MetabReview of studies2012
New detection methods of growth hormone and growth factors.Endocr DevReview of studies2012
The growth hormone secretagogue receptor (Ghs-R).Curr Pharm DesReview of studies2012
History of growth hormone therapy.Indian J PediatrReview of studies2012
Pleiotropic effects of growth hormone signaling in aging.Trends Endocrinol MetabReview of studies2011
Growth hormone deficiency in the transition period: body composition and gonad function.J Endocrinol InvestReview of studies2011
Detecting growth hormone abuse in athletes.Anal Bioanal ChemReview of studies2011
Growth hormone doping: a review.Open Access J Sports MedReview of studies2011
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.Endocr RevReview of studies2011
Growth hormone and physical performance.Trends Endocrinol MetabReview of studies2011
Growth hormone, insulin and aging: the benefits of endocrine defects.Exp GerontolReview of studies2011
Hepatocyte Growth Hormone Receptor Ablation Is Associated With Aging Phenotypes and Hepatic Mitochondrial Dysfunction.Aging CellIn animals2026
Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex-Specific Hepatic Transcriptional Changes at Single-Cell Resolution.Aging CellIn animals2026
Active immunization against myostatin and activin A improves skeletal muscle performance in growth hormone-deficient mice.GeroscienceIn animals2026
The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells.PituitaryIn animals2026
Sex-Specific transcriptomic changes in adipose tissue following adult-onset disruption of growth hormone receptor.PituitaryIn animals2025
Growth hormone excess drives liver aging via increased glycation stress.Aging (Albany NY)In animals2025
Aging Effects on Absolute and Relative Estrogen Receptor Variant Gene Expression Levels in Male Versus Female Rat Ventromedial Hypothalamic Nucleus Growth Hormone-Releasing Hormone Neurons.J Integr NeurosciIn animals2025
Growth hormone-deficient Ames dwarf mice resist sarcopenia and exhibit enhanced endurance running performance at 24 months.GeroscienceIn animals2025
Growth Hormone Alters Remapping in the Hippocampal Area CA1 in a Novel Environment.eNeuroIn animals2025
Isolating the direct effects of growth hormone on lifespan and metabolism in mice.Aging CellIn animals2024
Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy.GeroscienceIn animals2024
Growth hormone-releasing hormone deficiency confers extended lifespan and metabolic resilience during high-fat feeding in mid and late life.Aging CellIn animals2024
Unveiling ceramide dynamics: Shedding light on healthy aging in growth hormone-releasing hormone knockout mice.Aging CellIn animals2024
Growth hormone reduces aneuploidy and improves oocytes quality by JAK2-MAPK3/1 pathway in aged mice.J Transl MedIn animals2023
Efficacy of a growth hormone-releasing hormone agonist in a murine model of cardiometabolic heart failure with preserved ejection fraction.Am J Physiol Heart Circ PhysiolIn animals2023
Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner.GeroscienceIn animals2023
microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling.Proc Natl Acad Sci U S AIn animals2023
Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle.J Mol Med (Berl)In animals2022
Disruption of Growth Hormone Receptor in Adipocytes Improves Insulin Sensitivity and Lifespan in Mice.EndocrinologyIn animals2022
Characterization of growth hormone secretagogue small molecule ibutamoren (MK-0677) and its possible metabolites in thoroughbred horses for doping control.Rapid Commun Mass SpectromIn animals2022
Excess Growth Hormone Alters the Male Mouse Gut Microbiome in an Age-dependent Manner.EndocrinologyIn animals2022
Equine metabolism of the growth hormone secretagogue MK-0677 in vitro and in urine and plasma following oral administration.Drug Test AnalIn animals2022
Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries.GeroscienceIn animals2022
Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice.Aging (Albany NY)In animals2022
Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan.Aging CellIn animals2021
Improvement of cardiac and systemic function in old mice by agonist of growth hormone-releasing hormone.J Cell PhysiolIn animals2021
Growth hormone secretagogue receptor-1a mediates ghrelin's effects on attenuating tumour-induced loss of muscle strength but not muscle mass.J Cachexia Sarcopenia MuscleIn animals2021
Growth Hormone As Antiaging Factor in Old Bones.Rejuvenation ResIn animals2021
Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.AutophagyIn animals2021
Growth hormone ameliorates the age-associated depletion of ovarian reserve and decline of oocyte quality via inhibiting the activation of Fos and Jun signaling.Aging (Albany NY)In animals2021
The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice.Aging (Albany NY)In animals2020
Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.Aging (Albany NY)In animals2020
Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone.Aging (Albany NY)In animals2020
Lifespan of long-lived growth hormone receptor knockout mice was not normalized by housing at 30°C since weaning.Aging CellIn animals2020
Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.Aging (Albany NY)In animals2020
Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1.Learn MemIn animals2020
17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.Exp GerontolIn animals2020
Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor.MoleculesIn animals2019
Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation.Ann N Y Acad SciIn animals2018
Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.Mech Ageing DevIn animals2017
A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.J Gerontol A Biol Sci Med SciIn animals2017
Longevity is impacted by growth hormone action during early postnatal period.ElifeIn animals2017
Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses.EndocrinologyIn animals2017
Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.J Gerontol A Biol Sci Med SciIn animals2017
Growth hormone actions during development influence adult phenotype and longevity.Exp GerontolIn animals2016
Ginkgoghrelins, unique acylated flavonoid diglycosides in Folium Ginkgo, stimulate growth hormone secretion via activation of the ghrelin receptor.J EthnopharmacolIn animals2016
Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling.Aging (Albany NY)In animals2016
Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.Cell RepIn animals2016
Influence of aging and growth hormone on different members of the NFkB family and IkB expression in the heart from a murine model of senescence-accelerated aging.Exp GerontolIn animals2016
Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.Aging CellIn animals2015
Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1.Folia Histochem CytobiolIn animals2015
Correlation of ghrelin concentration and ghrelin, ghrelin-O-acetyltransferase (GOAT) and growth hormone secretagogue receptor 1a mRNAs expression in the proventriculus and brain of the growing chicken.PeptidesIn animals2015
Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging.Aging CellIn animals2014
Growth hormone receptor signaling is dispensable for HSC function and aging.BloodIn animals2014
Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.J Gerontol A Biol Sci Med SciIn animals2014
Advances in the detection of growth hormone releasing hormone synthetic analogs.Drug Test AnalIn a lab dish2021
Impact of the Transfersome Delivered Human Growth Hormone on the Dermal Fibroblast Cells.Curr Pharm BiotechnolIn a lab dish2019
The effect of recombinant human growth hormone and insulin-like growth factor-1 on the mitochondrial function and viability of peripheral blood mononuclear cells in vitro.Appl Physiol Nutr MetabIn a lab dish2015
Melatonin, and to a lesser extent growth hormone, restores colonic smooth muscle physiology in old rats.J Pineal ResIn a lab dish2011
Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning.NeuroscienceIn a lab dish2004
Body composition and vascular effects of growth hormone administration in old female rats.Exp GerontolIn a lab dish2003
Cortical elasticity in aging rats with and without growth hormone treatments.J Med Eng TechnolIn a lab dish1996
Growth hormone administration to aged rats improves membrane electrical properties of skeletal muscle fibers.J Pharmacol Exp TherIn a lab dish1994
Relationship between growth hormone-releasing hormone and somatostatin in the rat: effects of age and sex on content and in-vitro release from hypothalamic explants.J EndocrinolIn a lab dish1989
Growth hormone and aging cardiomyocytes.Cardiovasc ResOther paper2026
Local growth hormone promotes benign prostatic hyperplasia.JCI InsightOther paper2026
Sex-specific circadian and behavioral phenotypes in aged growth hormone receptor knockout mice.GeroscienceOther paper2026
Effects of Growth Hormone (GH) Deficiency and GH Replacement Therapy on Health-Related Physical Fitness in Children.J Clin Endocrinol MetabOther paper2026
Growth Hormone-Releasing Peptides: Investigation of Their Secondary Structure, Thermal Stability, and Model Membrane Interactions.ChiralityOther paper2026
Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.J Pharm Biomed AnalOther paper2026
Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue.Clin Chim ActaOther paper2026
Comparison of ventromedial hypothalamic nucleus growth hormone-releasing hormone neuron counterregulatory neurochemical marker gene expression in young adult versus middle-aged male and female rats.IBRO Neurosci RepOther paper2025
Impact of Growth Hormone on Skeletal Muscle Strength, Power, Endurance, and Agility in Prepubertal Boys With Short Stature.J Clin Endocrinol MetabOther paper2025
The Impact of K-1 Kickboxing Tournament Fights on Growth Hormone, IGF-1, and Insulin Levels: Preliminary Findings from a Pilot Study in Elite Athletes.J Clin MedOther paper2025
Administration study of somapacitan, a long-acting growth hormone derivative, in horse for doping control purpose.Growth Horm IGF ResOther paper2025
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment.Aging CellOther paper2025
Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs.Front Vet SciOther paper2025
Growth hormone treatment associates with improved circulating anti-aging protein Klotho and reduced arterial stiffness in children with CKD.Clin Kidney JOther paper2025
Circulating growth hormone, cortisol and testosterone in relation to vitamin D status: influence of lower and upper body wingate anaerobic test in elite artistic gymnasts.BMC Sports Sci Med RehabilOther paper2025
Development of Competitive ELISAs Suitable for Detection of Recombinant Human Growth Hormone in Illegal Nutritional Supplements.J Anal Methods ChemOther paper2025
Evaluation of Epigenetic Age Acceleration in Growth Hormone (GH)-Deficient Children After 6 Months of Recombinant Human GH Replacement Therapy: Anti-Ageing GH vs. Pro-Ageing Insulin-like Growth Factor 1 (IGF-1)?J Clin MedOther paper2025
Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease.Arch ToxicolOther paper2025
Identification and differentiation of somapacitan, a long-acting growth hormone derivative, and recombinant human growth hormone in equine plasma by LC-HRMS for doping control purpose.Growth Horm IGF ResOther paper2025
Growth Hormone Excess Drives Liver Aging via increased Glycation stress.bioRxivOther paper2025
Isolating the Direct Effects of Growth Hormone on Lifespan and Metabolism.bioRxivOther paper2024
The protection role of human growth hormone on skin cells following ultraviolet B exposure.J Photochem Photobiol BOther paper2024
Non-pituitary growth hormone enables colon cell senescence evasion.Aging CellOther paper2024
Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency.MedOther paper2024
Development of nano-liposomal human growth hormone as a topical formulation for preventing uvb-induced skin damage.Int J Biol MacromolOther paper2024
Metabolic Consequences of Anabolic Steroids, Insulin, and Growth Hormone Abuse in Recreational Bodybuilders: Implications for the World Anti-Doping Agency Passport.Sports Med OpenOther paper2024
Medical Costs Associated with High/Moderate/Low Likelihood of Adult Growth Hormone Deficiency: A Healthcare Claims Database Analysis.Clinicoecon Outcomes ResOther paper2024
Production and engineering of nanobody-based quenchbody sensors for detecting recombinant human growth hormone and its isoforms.Drug Test AnalOther paper2023
A cluster of X-linked miRNAs are de-repressed with age in mouse liver and target growth hormone signaling.Front AgingOther paper2023
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum.Growth Horm IGF ResOther paper2023
Can Growth Hormone Lead to a Faster Recovery from Guillain-Barré Syndrome? Case Report of the First Therapeutic Use in One Patient.Case Rep NeurolOther paper2023
The effect of growth hormone-induced cellular behavior and signaling properties on induced cellular senescence in human mesenchymal stem cells.Tissue CellOther paper2022
Growth Hormone Stimulates Murine Macrophage Migration during Aging.Curr Aging SciOther paper2022
Delayed Recovery after Nonoperative Treatment of an Avulsion Fracture of the Ischial Tuberosity in an Adolescent Gymnast with a History of Growth Hormone Deficiency: A Case Report.Int J Sports Phys TherOther paper2022
Combined statistical decision limits based on two GH-2000 scores for the detection of growth hormone misuse.Stat Methods Med ResOther paper2022
Growth hormone isoform testing in capillary dried blood spots: Results from single and multiple dose administration studies and large-scale field collections.Drug Test AnalOther paper2022
Development of a Novel Algorithm to Identify People with High Likelihood of Adult Growth Hormone Deficiency in a US Healthcare Claims Database.Int J EndocrinolOther paper2022
An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS.J Pharm Biomed AnalOther paper2022
Development of a microplate duplex immunoassay to simplify detection of growth hormone doping: Proof of concept.Drug Test AnalOther paper2022
Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations.Front Sports Act LivingOther paper2022
Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage.Cell RepOther paper2021
The Proteomic Signature of Recombinant Growth Hormone in Recreational Athletes.J Endocr SocOther paper2021
An exercise "sweet spot" reverses cognitive deficits of aging by growth-hormone-induced neurogenesis.iScienceOther paper2021
A retrospective analysis of growth hormone therapy in children with Schaaf-Yang syndrome.Clin GenetOther paper2021
Delaying Effects of Prolactin and Growth Hormone on Aging Processes in Bovine Oocytes Matured In Vitro.Pharmaceuticals (Basel)Other paper2021
Coupling Complete Blood Count and Steroidomics to Track Low Doses Administration of Recombinant Growth Hormone: An Anti-Doping Perspective.Front Mol BiosciOther paper2021
Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension.Aging (Albany NY)Other paper2021
Growth Hormone as a Potential Mediator of Aerobic Exercise-Induced Reductions in Visceral Adipose Tissue.Front PhysiolOther paper2021
Impact of Long-Term Growth Hormone Replacement Therapy on Metabolic and Cardiovascular Parameters in Adult Growth Hormone Deficiency: Comparison Between Adult and Elderly Patients.Front Endocrinol (Lausanne)Other paper2021
Comparison of normal distribution-based and nonparametric decision limits on the GH-2000 score for detecting growth hormone misuse (doping) in sport.Biom JOther paper2021
Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.J Chromatogr AOther paper2020
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.Mol MedOther paper2020
Insulin sensitivity in long-lived growth hormone-releasing hormone knockout mice.Aging (Albany NY)Other paper2020
Applying metabolomics to detect growth hormone administration in athletes: Proof of concept.Drug Test AnalOther paper2020
Longitudinal studies of putative growth hormone (GH) biomarkers and hematological and steroidal parameters in relation to 2 weeks administration of human recombinant GH.Drug Test AnalOther paper2020
OFF-LABEL USE AND MISUSE OF TESTOSTERONE, GROWTH HORMONE, THYROID HORMONE, AND ADRENAL SUPPLEMENTS: RISKS AND COSTS OF A GROWING PROBLEM.Endocr PractOther paper2020
Early Detection of Growth Hormone Secretagogue Receptor Antagonists Exploiting Their Atypical Behavior in Competitive Assays.Anal ChemOther paper2019
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.Endocr PractOther paper2019
Combined administration of microdoses of growth hormone and erythropoietin: Effects on performance and evaluation of GH detection capability using anti-doping methods.Drug Test AnalOther paper2019

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Registered studies in people (129)

StudiesStageStatusPeople taking partUpdated
Severe Decrease of Growth Velocity in Children With Anorexia Nervosa.Therapeutic Trial of Growth HormoneStage 2, Stage 3Finished152026-10-27
Growth Hormone Administration and the Human Immune SystemStage 1Finished662026-10-26
A Research Study in Children Born Small and Who Stayed Small. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a DayStage 2Running, no new people622026-10-06
Charactertizing Growth Hormone Deficiency in Traumatic Brain Injury–Looking for people2002026-08-31
A Study to Learn How Different Injector Pens Affect the Study Medicine Called Genotropin (Somatropin) Delivery and Taken up Into the Blood in Healthy AdultsStage 1Finished272026-08-10
Growth Hormone Resistance of Beta-cells–Not started102026-08-06
A Study of GS3-007a for Oral Suspension in the Diagnosis of Adult Growth Hormone Deficiency (AGHD)Stage 2Stopped early1202026-05-22
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIVStage 2Looking for people1002026-05-19
Growth Hormone Resistance of Beta-cells A–Looking for people302026-05-11
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes–Looking for people302026-05-11
Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes–By invitation602026-05-06
Growth Hormone for the Treatment of GastroparesisEarly stage 1Looking for people102026-04-16
A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD)Stage 1Looking for people642026-04-14
Effects of GH and Lirglutide on AgRPStage 4Looking for people402026-03-04
Effects of Ketone Bodies on Insulin Sensitivity–Looking for people102026-01-22
Chromosome 18 Clinical Research Center–Looking for people40002026-01-06
Growth and Asymmetric diMethylArginine–Finished232025-12-16
Growth Hormone in Decompensated Liver CirrhosisStage 2, Stage 3Finished962025-12-16
Reproducibility and Utility of OGTT in Acromegaly–Finished1092025-11-24
Skeletal Muscle Effects of GH in Boys–Finished452025-11-04
Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy–Finished102025-09-03
A Prospective Study of Outcome After Therapy for Acromegaly–Finished2802025-08-26
A Bioequivalence Study of Two Different PEG-rhGH PreparationsStage 1Finished872025-08-08
Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy–Finished72025-05-13
Adipose Tissue and Serum Inflammation in GH Deficiency–Finished192025-05-13
A Clinical Trial to Compare Pharmacokinetics of Two Different PEG-rhGH PreparationsStage 1Finished482025-04-03
A Clinical Trail to Compare Pharmacokinetics of Two PEG-rhGH Injections With Different PreparationsStage 1Finished602025-04-03
A Bioavailability Study of Two Different PEG-rhGH Preparations.Stage 1Finished162025-04-03
Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact–Finished1012025-04-01
Bone Structure in Patients With Adult Onset Growth Hormone Deficiency Assessed Using High Resolution Peripheral Quantitative Computed Tomography–Finished452025-03-21
A Bioequivalence Study of Two Different Processes of PEG-rhGH PreparationsStage 1Not started872025-02-21
Co-Feedback Action of Growth Hormone, PP and PYY on Ghrelin in BulimiaStage 2By invitation242025-02-19
Effects of Growth Hormone (GH) Deficiency and Growth Hormone Replacement on Serum Fibroblast Growth Factor 21 (FGF21)–Withdrawn02024-12-18
A Bioequivalence Study of Two Different PEG-rhGH Preparations.Stage 1Finished872024-11-08
Novel Predictors of Premature Aging in COPD Patients–Unknown1002023-08-31
Low Load Resistance Exercises With Blood Flow Restriction Versus High Load Resistance Exercises–Finished222023-08-16
The Effects of Growth Hormone Treatment Discontinuation in Adults on Metabolic Profile, Body Composition and Quality Of Life (GAMBOL Study)–Unknown252023-08-07
Growth Hormone, IGF-1 and Medical Treatment in Acromegaly: Are There Effects on Gut Hormone Physiology and Postprandial Substrate Metabolism?–Finished212022-12-29
The Impact of the Use of Recombinant Human Growth Hormone on ADHD Characteristics in Children and Adolescents–Unknown1002022-08-09
In Vivo Assessment of Cellular Metabolism in HumansStage 1Finished172022-08-03
Effect of Exogenous Growth Hormone on Ocular Findings–Unknown902022-04-21
A Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar TendinopathyStage 2Withdrawn02022-03-31
Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin ResistanceStage 1, Stage 2Withdrawn02021-01-08
Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency–Finished752020-09-02
Exploring Interactions Between Growth Hormone and the Microbiome–Unknown2002020-07-22
Gene Expression in Monocytes of Growth Hormone Deficient Children–Unknown402020-05-14
6x3 Crossover, Bioavailability, Safety and Tolerability Among Different Eutropin Formulations in Healthy VolunteersStage 1Finished242020-03-24
Generation of Biological Samples Positive to Somatropin for Anti-doping ControlStage 1Finished62020-02-12
The Effect of Growth Hormone Releasing Hormone on Cognitive Function in Individuals With Mild Cognitive ImpairmentStage 1Finished222019-11-04
MOD-4023 Study in Healthy Male VolunteersStage 1Finished242019-09-30
Pharmacokinetics and Pharmacodynamics of Long Acting Human Growth Hormone (hGH) Product (MOD-4023) in Healthy Caucasian and Japanese VolunteersStage 1Finished422019-09-30
Long-term Safety Follow-up After Growth Hormone Treatment of Short Children Born Small for Gestational Age–Stopped early1302019-08-14
Investigation of a New, Oral Growth Hormone Secretagogue, AEZS-130 as a Growth Hormone Stimulation Test.Stage 3Finished1012019-07-23
The Effect of GHRH Therapy on Myocardial Structure and Function in Congestive Heart FailureStage 2Finished32019-07-09
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)–Finished282019-07-09
Assessment of the Acute Effect of IP–Finished322019-05-31
Three Month Treatment of Growth Hormone Releasing Hormone (GHRH) in the ElderlyStage 2Stopped early132019-05-24
Single Low-Dose of Supplement Amino Acid–Finished162018-10-22
Fitness Level in Short Stature Children and After Growth Hormone Treatment–Unknown502018-10-05
Non-inferiority Evaluation of Pain Intensity After Biomatrop (Somatropin) Application in Relation to Hormotrop (Somatropin), in Healthy SubjectsStage 4Unknown682018-08-17
Effect of DPP4 Inhibition on Growth Hormone SecretionStage 4Finished442018-05-29
Evalutation of Insulin Sensitivity Through Hyperinsulinemic Clamp in Children With GH Deficiency–Finished232018-05-15
Effects of Growth Hormone Supplementation to Adults With Growth Hormone Deficient on Metabolism and Adipose Tissue Molecular Phenotype–Finished442018-04-17
Validation of Macimorelin as a Test for Adult Growth Hormone DeficiencyStage 3Finished1572018-04-10
Progesterone Amplifies Estrogen-stimulated Growth Hormone Secretion in Older WomenStage 1Finished472018-03-22
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine–Finished162018-02-08
Substrate Metabolism, Growth Hormone Signaling (GH), and Insulin Sensitivity During GH and Ketone Bodies Infusion–Finished102017-11-01
Role of Nutrition and Hormones in Boys With Disordered GrowthStage 2Finished202017-07-02
The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis–Finished432017-05-17
Study of Intranasal Octreotide (DP1038) in Healthy Adult VolunteersStage 1Finished322017-05-12
Six Month Treatment of Growth Hormone Releasing Hormone (GHRH) in the ElderlyStage 2Stopped early52017-04-27
304-C03/L3301n: Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency–Unknown202017-04-12
A Single Dose Trial in Healthy Caucasians and Japanese Subjects Investigating the Pharmacokinetics of SomatropinStage 1Finished862017-02-27
Bioequivalence of Two Somatropin Products (Norditropin® Versus Genotropin®) in Healthy Adult VolunteersStage 1Finished302017-02-24
Dose Study in Healthy Males Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083 Compared to Norditropin® SimpleXx®Stage 1Finished562017-02-09
Pharmacokinetics of Somatropin in Patients With End Stage Renal Disease Receiving Chronic HaemodialysisStage 1Finished212017-01-24
Diagnosing Adult Growth Hormone Deficiency–Finished1602017-01-12
Substrate Metabolism, Growth Hormone Signaling, and Insulin Sensitivity During Fasting–Finished102016-11-23
Impact of Endogenous E2 on SSI and GH ReboundStage 1Finished622016-03-16
Growth Hormone as a Determinant of Weight Regulation–Finished242016-01-01
Growth Hormone Releasing Hormone (GHRH) Treatment for Age-Related Sleep Disturbances–Finished–2015-12-03
Role of Endogenous Estrogen in Growth-Hormone Regulation in Postmenopausal WomenStage 1Finished302015-03-27
A Trial to Investigate the Bioequivalence of Norditropin® (Somatropin) Versus Genotropin® (Somatropin) in Healthy Adult SubjectsStage 1Finished322015-03-19
Growth Hormone Evaluation in the Elderly People–Finished482014-09-15
Effects of Growth Hormone Administration on Muscle Strength and Body Composition in Men Over 50 Years OldStage 4Finished132014-09-03
Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone DeficiencyStage 3Finished692014-08-05
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity–Finished192014-05-26
Abdominal Obesity, Cardiovascular Inflammation, and Effects of Growth Hormone Releasing Hormone Analogue–Withdrawn02014-01-24
SMART: Somatotrophics, Memory, and Aging Research TrialStage 2Finished1512013-12-19
r-hGH Liquid Multidose Versus Freeze-dried Multidose Bioequivalence TrialStage 1Finished302013-10-23
ATS-1 Needle Free Injection Device Study-a Device for Administering r-hGH (Saizen) to Treat Growth Hormone DeficiencyStage 1Finished382013-10-22
Bioequivalence of Two Products (Norditropin® Versus Nutropin AQ®) in Healthy Adult VolunteersStage 1Withdrawn02013-09-16
Effect of Fasting on Ghrelin and Growth Hormone in Healthy Young and Older Adults–Finished212013-08-14
The Effects of Growth Hormone (GH) on Lipid Depots–Finished342013-08-13
Study of Glucagon, Ghrelin and Growth Hormone as Counterregulatory Hormones–Unknown62013-02-20
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Pegylated-Somatropin in Healthy VolunteersStage 1Finished362013-02-04
Metabolic Studies- Interactions Between GH and Insulin in GHDA–Finished82013-01-21
Safety, Pharmacokinetics and Pharmacodynamics Study of HL-032 in Healthy Male VolunteersStage 1Finished402012-10-16
Evaluation of Pharmacokinetic and Pharmacodynamic Parameters of Somatropin Produced by Laboratory Blausiegel Indústria e Comércio Ltda., Compared to Saizen® From Laboratory Merck Serono S.A.Stage 1Unknown322012-09-25
Testosterone-Driven Growth-Hormone (GH) Secretion in Aging MenStage 1Finished802012-07-31
Safety Study of Syntropin (Human Growth Hormone) for the Treatment of Growth Hormone DeficiencyStage 1Finished202012-03-12
Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited AdultsStage 2Stopped early3962012-02-02
Evaluate the Effect of Growth Hormone (GH) Treatment on Fibroblast Growth Factor 23, a Known Phosphaturic Agent–Finished352011-11-16
Growth Hormone Treatment of Women With Turner Syndrome–Finished242011-11-08
The Effect of Local Injectet GH on the Collagen Synthesis in the Ligamentum Patella–Finished122011-11-07
Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction–Finished102011-09-13
Effect of Short Term Growth Hormone Releasing Hormone in Healthy Men–Finished152011-04-19
Consequence of Lifetime Isolated Growth Hormone Deficiency–Finished4002010-06-15
Pharmacokinetics and Pharmacodynamics of ACP-001 (TransCon PEG hGH)Stage 1Finished442010-06-08
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing–Finished902010-03-05
Ghrelin, Growth Hormone and Growth Factors at High Altitude–Finished–2010-02-23
Induction and Expansion of T Cell Repertoire Using Growth Hormone and Vaccination in HIV-1 Infected PatientsStage 4Finished332009-11-04
Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency–Finished242009-10-22
The Relationship Between the Growth Hormone (GH)- Insulin Like Growth Factor I (IGF-I) System and the Inflammatory System in Healthy Normal Persons–Unknown122009-09-01
Effects of Donepezil on Deficits Associated With Age-Related Decrease of Growth Hormone–Finished802009-08-07
HORMA: Hormonal Regulators of Muscle and Metabolism in AgingStage 2Finished1082009-06-02
Effect of Growth Hormone on Insulin Signaling in Muscle Tissue–Finished82009-04-21
Cardiovascular Risk in Growth Hormone Deficient Young Adult Males After Completing Growth Hormone Therapy–Finished242009-02-10
Pioglitazone Treatment in Polycystic Ovary SyndromeStage 4Finished302008-09-26
Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content–Finished102008-08-12
Evaluation the Growth Factors(IGF-1,IGFBP-3and HGH)in Patients With Chronic Liver Disease–Finished2102008-05-19
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With EtanerceptStage 2Finished362008-03-04
Growth Hormone Administration and Its Effects on Cardiovascular Risk Factors in Growth Hormone Deficient Women–Finished632008-02-18
Effect of 5 Years of GH Replacement on Atherosclerosis–Finished202007-10-16
Growth Hormone's Effect on the Cardiovascular System–Stopped early262007-07-03
Growth Hormone's Effect on Endothelial Progenitor Cells–Finished182007-07-03
Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older AdultsStage 1, Stage 2Finished722007-05-16
Effects of Growth Hormone on the Nitric Oxide PathwayStage 1Finished162007-05-07
Growth Hormone and Heart Failure–Stopped early1802005-09-19