# Sermorelin

GRF(1-29) · GHRH(1-29) · Geref

https://graded.pl/en/substances/sermorelin · Checked: Not yet

Preliminary version. The editors have not finished checking this card, and grades may change.

A fragment of the hormone that tells the body to release growth hormone. It was sold in the US as Geref, which has since been withdrawn.

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## Short answers

### Does sermorelin work?

A fragment of the hormone that tells the body to release growth hormone. It was sold in the US as Geref, which has since been withdrawn. Muscle mass: grade D, conflicting results. One small study of 19 people aged 55 to 71, without random groups: everyone got placebo first, then the drug. Body mass without fat rose in men but not in women. No study tested people who train.

### Is Sermorelin legal?

PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. The FDA register marks Geref as withdrawn.

### Is sermorelin banned in sport?

Banned in sport, WADA 2026.

### Is Sermorelin safe?

Little data. Described as a test and a treatment for children short of growth hormone. That says nothing about adults using it for muscle or ageing.

## What studies show

| | | | |
|---|---|---|---|
| Muscle mass | D | Conflicting results | One small study of 19 people aged 55 to 71, without random groups: everyone got placebo first, then the drug. Body mass without fat rose in men but not in women. No study tested people who train. |

## Studies we have read

- Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. (J Clin Endocrinol Metab 1997; No random groups, n=19) https://pubmed.ncbi.nlm.nih.gov/9141536/

## Is it legal

- PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- US: No approval. The FDA register marks Geref as withdrawn. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019863 (Checked: Not yet)

## Doping

Banned in sport, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html

## How much research exists

- Scientific papers: 366
- Studies with random groups: 34
- Registered studies in people: 27
- These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

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Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/