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The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
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Semax

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Scientific papers

StudiesKind of studyYear
[The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax].Zh Nevrol Psikhiatr Im S S KorsakovaRandom groups2007
[The efficacy of semax in the tretament of patients at different stages of ischemic stroke].Zh Nevrol Psikhiatr Im S S KorsakovaNo random groups2018
[Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease].Vestn OftalmolNo random groups2000
[Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)].Zh Nevrol Psikhiatr Im S S KorsakovaNo random groups1997
Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.Int J Pharm CompdReview of studies2026
Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.Front AgingReview of studies2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res RevReview of studies2026
Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases.NeuropeptidesReview of studies2025
Pharmacological Aspects of Neuro-Immune Interactions.Curr Pharm DesReview of studies2018
[POSSIBLE ROLE OF TRANSTHYRETIN IN THE BIOLOGICAL MECHANISM OF THE REGULATORY PEPTIDE NEUROPROTECTION.].Mol Gen Mikrobiol VirusolReview of studies2016
Sigmoidal maximal effect modeling of low-density lipoprotein cholesterol concentration and annual incidence of coronary heart disease events in secondary prevention trials.PharmacotherapyReview of studies2014
[Neuroprotective effects of peptides bioregulators in people of various age].Adv GerontolReview of studies2013
[Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats].OntogenezReview of studies2012
[Evolution of the stress concept].Vestn Ross Akad Med NaukReview of studies2008
[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application].Izv Akad Nauk Ser BiolReview of studies2006
Quantitative MRI Pharmacokinetic Modeling and MALDI Mass Spectrometry Imaging Biodistribution of a pH Mapping MRI Contrast Agent.TheranosticsIn animals2026
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.Br J PharmacolIn animals2025
The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.Bull Exp Biol MedIn animals2025
Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage.Int J Mol SciIn animals2025
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.Eur J PharmacolIn animals2024
Changes of Transcriptomic Activity in Rat Brain Cells under the Influence of Synthetic Adrenocorticotropic Hormone-Like Peptides.Biochemistry (Mosc)In animals2024
Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats).F1000ResIn animals2023
Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period.Genes (Basel)In animals2023
Synthetic corticotropins and the GABA-receptor system: Direct and delayed effects.Chem Biol Drug DesIn animals2023
Insight into Glyproline Peptides' Activity through the Modulation of the Inflammatory and Neurosignaling Genetic Response Following Cerebral Ischemia-Reperfusion.Genes (Basel)In animals2022
Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress.Int J Mol SciIn animals2021
Investigation of the effect of a modified fragment of neuropeptide Y on memory phases and extrapolation escape of animals.Ceska Slov FarmIn animals2021
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion.Int J Mol SciIn animals2021
[The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain].Mol Biol (Mosk)In animals2021
Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.NeuropeptidesIn animals2021
Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax).Bull Exp Biol MedIn animals2021
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.Curr Rev Clin Exp PharmacolIn animals2021
Peptide ACTH4-7-PGP: Effects on Various Types of Pain and Pain-Induced Behavior in Rats after Systemic and Central Administration.Bull Exp Biol MedIn animals2020
Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress.Bull Exp Biol MedIn animals2020
Correction of Lipid Metabolism Disorders in Diabetes Mellitus with Peptide Drugs.Bull Exp Biol MedIn animals2020
An integrated approach to study the molecular aspects of regulatory peptides biological mechanism.J Labelled Comp RadiopharmIn animals2019
Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of "Social" Stress.Bull Exp Biol MedIn animals2019
Modulation of GABA- and Glycine-Activated Ionic Currents with Semax in Isolated Cerebral Neurons.Bull Exp Biol MedIn animals2018
Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.Bull Exp Biol MedIn animals2017
Changes in Sympathetic Innervation of the Heart in Rats with Experimental Myocardial Infarction. Effect of Semax.Bull Exp Biol MedIn animals2017
Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats.Mol Genet GenomicsIn animals2017
Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.Dokl Biol SciIn animals2017
Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress.Bull Exp Biol MedIn animals2017
Synacton and individual activity of synthetic and natural corticotropins.J Mol RecognitIn animals2017
Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide.Bull Exp Biol MedIn animals2016
Semax prevents learning and memory inhibition by heavy metals.Dokl Biol SciIn animals2016
[The effect of peptide ACTH4-7-PGP on functional hepatocyte state in rats in acute and chronic foot-shock stress].Ross Fiziol Zh Im I M SechenovaIn animals2015
[THE EFFECT OF ACTH-(4-7)-PGP PEPTIDE ON LIPID PEROXIDATION IN LIVER AND ACTIVITY OF SERUM TRANSAMINASES IN RATS UNDER ACUTE AND CHRONIC IMMOBILIZATION STRESS CONDITIONS].Eksp Klin FarmakolIn animals2015
[EFFECT OF PEPTIDE SEMAX ON SYNAPTIC ACTIVITY AND SHORT-TERM PLASTICITY OF GLUTAMATERGIC SYNAPSES OF CO-CULTURED DORSAL ROOT GANGLION AND DORSAL HORN NEURONS].Fiziol Zh (1994)In animals2015
[Study of neuroprotective, antihypoxic and antiamnesic effects of new mixture of tripeptides].Eksp Klin FarmakolIn animals2015
The action of the peptide drug Semax on the currents of AMPA receptors of rat cerebellar Purkinje cells.Dokl Biochem BiophysIn animals2015
[Effects of neonatal fluvoxamine administration to white rats and their correction by semax treatment].Izv Akad Nauk Ser BiolIn animals2014
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.BMC GenomicsIn animals2014
[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].Mol Biol (Mosk)In animals2014
[Opposite Semax influence on conditioning and functional disturbances of avoidance responses in rats].Zh Vyssh Nerv Deiat Im I P PavlovaIn animals2013
Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats.Dokl Biol SciIn animals2013
[Proteolysis of simple glyprolines by leucine aminopeptidase and enzymes from nasal slime, brain membranes, and rat blood].Bioorg KhimIn animals2013
[The effect of semax and its C-end peptide PGP on Vegfa gene expression in the rat brain during incomplete global ischemia].Mol Biol (Mosk)In animals2013
Study of proteolysis of Semax analogues with different N-terminal amino acids by carboxypeptidases.Dokl Biol SciIn animals2013
Semax corrects brain dysfunction caused by prenatal introduction of valproic acid.Dokl Biol SciIn animals2013
Stability of Semax acetyl to proteolysis in various biological media.Dokl Biol SciIn animals2013
Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.J Mol NeurosciIn animals2013
Semax prevents functional impairments of avoidance response in rats.Dokl Biol SciIn animals2013
Antistress effect of Semax in the course of recovery of spleen lymphoid structures after the stress in rats with different behavioral activity.Bull Exp Biol MedIn animals2012
[The comparison of neuroprotective action of antibodies to glutamate and drug preparation semax in the focal ischemic damage of the brain prefrontal cortex of rats].Patol Fiziol Eksp TerIn animals2012
Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats.Bull Exp Biol MedIn animals2012
[Effects of nootropic drugs on behavior of BALB/c and C57BL/6 mice in the exploratory cross-maze test].Eksp Klin FarmakolIn animals2012
[The effect of semax and its C-end peptide PGP on expression of the neurotrophins and their receptors in the rat brain during incomplete global ischemia].Mol Biol (Mosk)In animals2011
[Proteolysis of semax analogues with different N-terminal amino acids by aminopeptidases].Bioorg KhimIn animals2011
Semax increases erythrocyte deformability in the shearing blood stream in intact rats and rats with cerebral ischemia.Dokl Biol SciIn animals2011
[Studying specific effects of nootropic drugs on glutamate receptors in the rat brain].Eksp Klin FarmakolIn animals2011
[Nootropic and analgesic effects of Semax following different routes of administration].Ross Fiziol Zh Im I M SechenovaIn animals2010
Anticoagulation and antiplatelet effects of semax under conditions of acute and chronic immobilization stress.Bull Exp Biol MedIn animals2010
[Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress].Izv Akad Nauk Ser BiolIn animals2010
Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax.Bull Exp Biol MedIn a lab dish2007
[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].Bioorg KhimIn a lab dish2006
Effects of Semax on Ca2+ responses of human neutrophils.Dokl Biol SciIn a lab dish2000
[Effect of semax and its mixture with heparin on the activity of isolated heart after total ischemia].Biull Eksp Biol MedIn a lab dish1999
Multi-Layer Magnetic Shields Based on Fe-Based Nanocrystalline and Co-Based Amorphous Ribbons.Materials (Basel)Other paper2026
Digitally Guided Hybrid Maxillary Expansion with Supragingival Mandibular Miniplates for Class III Correction in Late Adolescents: A Pilot Clinical Study.J Clin MedOther paper2026
[Expert Council resolution: adjunctive pharmacotherapy for hyperkinetic disorders (attention deficit hyperactivity disorder) in children and adolescents].Zh Nevrol Psikhiatr Im S S KorsakovaOther paper2026
[Changes in retinal light sensitivity and morphometry during surgical treatment of primary glaucoma with physiotherapeutic stimulation].Vestn OftalmolOther paper2026
[Effect of a combined physiotherapeutic approach on changes in functional parameters after endovitreal surgery of rhegmatogenous retinal detachment with a favorable anatomical outcome].Vestn OftalmolOther paper2026
The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease.Acta NaturaeOther paper2025
Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.Bioinorg Chem ApplOther paper2025
Robust Multifunctional Films with Excellent EMI Shielding, Anti-Peeling, and Joule Heating Performances Enabled by an Encapsulated Highly Conductive Fabric Strategy.SmallOther paper2025
ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke.BiomedicinesOther paper2024
Diagnostic Value of Different 3-D Shear Wave Elastography Sections in the Diagnosis of Thyroid Nodules.Ultrasound Med BiolOther paper2022
Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.ACS Chem NeurosciOther paper2022
[Results of the application of complex physiotherapeutic neurostimulation in optical neuropathies of various genesis].Vopr Kurortol Fizioter Lech Fiz KultOther paper2022
A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors.Acta NaturaeOther paper2021
Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis.Brain SciOther paper2021
Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.Genes (Basel)Other paper2020
Functional Connectomic Approach to Studying Selank and Semax Effects.Dokl Biol SciOther paper2020
The Use of Human Induced Pluripotent Stem Cells for Testing Neuroprotective Activity of Pharmacological Compounds.Biochemistry (Mosc)Other paper2019
Effects of Semax on the Default Mode Network of the Brain.Bull Exp Biol MedOther paper2018
Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology.Beilstein J NanotechnolOther paper2017
Risk Assessment of Florists Exposed to Pesticide Residues through Handling of Flowers and Preparing Bouquets.Int J Environ Res Public HealthOther paper2017
[A comparative chemoreactome analysis of mexidol].Zh Nevrol Psikhiatr Im S S KorsakovaOther paper2017
Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.J Inorg BiochemOther paper2016
[POSSIBLE DRUG CORRECTION OF LIPID METABOLISM DISTURBANCES ASSOCIATED WITH METABOLIC SYNDROME IN PATIENTS WITH PSORIASIS].Eksp Klin FarmakolOther paper2015
Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity.J Inorg BiochemOther paper2015
Optimizing entropy bounds for macroscopic systems.Phys Rev E Stat Nonlin Soft Matter PhysOther paper2014
[Antiaggregation activity of arachidonic acid conjugates with neurotropic peptides proglyprol and semax].Eksp Klin FarmakolOther paper2014
[The results of the application of the pre-formed physical factors and neuroprotective therapy for the rehabilitative treatment of the patients with diabetic retinopathy].Vopr Kurortol Fizioter Lech Fiz KultOther paper2013
Correction of long-lasting negative effects of neonatal isolation in white rats using semax.Acta NaturaeOther paper2012
The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.J Mol NeurosciOther paper2011
Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action.J Mol NeurosciOther paper2010
The use of phospholipid nanoparticles for increasing Semax resistance in various proteolytic biological media.Dokl Biol SciOther paper2009
Audiogenic epilepsy in young mice of different strains after neonatal semax treatment.Bull Exp Biol MedOther paper2008
Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome.Med HypothesesOther paper2007
Gateways to clinical trials.Methods Find Exp Clin PharmacolOther paper2005
Natural and hybrid ("chimeric") stable regulatory glyproline peptides.PathophysiologyOther paper2005
[Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency].Zh Nevrol Psikhiatr Im S S KorsakovaOther paper2005
Respiratory acoustic thoracic imaging (RATHI): assessing deterministic interpolation techniques.Med Biol Eng ComputOther paper2004
Therapy of peptic ulcer with semax peptide.Bull Exp Biol MedOther paper2002
Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions.Bull Exp Biol MedOther paper2001
[Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmic tone].Vestn OftalmolOther paper2001
Effects of Semax, a peptide ACTH4-10 analogue, on the respiratory burst in human neutrophils.Dokl Biol SciOther paper2001
[Semax and selank inhibit the enkephalin-degrading enzymes from human serum]].Bioorg KhimOther paper2001
[Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke].Zh Nevrol Psikhiatr Im S S KorsakovaOther paper1999
[Use of semax at a follow-up of patients with posthypoxic encephalopathy].Anesteziol ReanimatolOther paper1999
[A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study)].Zh Vyssh Nerv Deiat Im I P PavlovaOther paper1997
[Study of the analgesic effect of the semax preparation].Biull Eksp Biol MedOther paper1996
[Effect of the heptapeptide Semax on the human electroencephalogram].Biull Eksp Biol MedOther paper1996
[Increased resistance to hypoxia effected by the neuropeptide preparation SEMAX].Fiziol ChelovekaOther paper1992
[On dose-response curves and the receptor interaction of nondepolarizing neuromuscular blocking drugs (author's transl)].AnaesthesistOther paper1981

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