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| Comparative Effects of Guanidinoacetic Acid and Creatine on Body Composition, Muscle Strength, and Protein Metabolism Biomarkers in Older Adults: A Randomized Exploratory Pilot Trial.J Nutr Sci Vitaminol (Tokyo) | Random groups | 2026 |
| MyMD-1 Improves Health Span and Prolongs Life Span in Old Mice: A Noninferiority Study to Rapamycin.J Gerontol A Biol Sci Med Sci | Random groups | 2023 |
| Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.Geroscience | Random groups | 2019 |
| Whey Protein Hydrolysate Increases Amino Acid Uptake, mTORC1 Signaling, and Protein Synthesis in Skeletal Muscle of Healthy Young Men in a Randomized Crossover Trial.J Nutr | Random groups | 2019 |
| Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men.J Nutr Health Aging | Random groups | 2019 |
| TORC1 inhibition enhances immune function and reduces infections in the elderly.Sci Transl Med | Random groups | 2018 |
| Neuromuscular Electrical Stimulation Combined with Protein Ingestion Preserves Thigh Muscle Mass But Not Muscle Function in Healthy Older Adults During 5 Days of Bed Rest.Rejuvenation Res | Random groups | 2017 |
| Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localised prostate cancer.BMC Cancer | Random groups | 2017 |
| A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.Geroscience | Random groups | 2017 |
| Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men.J Nutr | Random groups | 2016 |
| Leucine-enriched amino acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino acid transporter expression in older men.J Nutr | Random groups | 2014 |
| Muscle protein synthetic responses to exercise: effects of age, volume, and intensity.J Gerontol A Biol Sci Med Sci | Random groups | 2012 |
| Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men.J Appl Physiol (1985) | Random groups | 2010 |
| Expanded antigen-specific donor regulatory T cells for GVHD prevention.Blood | No random groups | 2026 |
| Nonmyeloablative conditioning combined with the anti-CD117 antibody briquilimab in older adults with high-risk AML and MDS.Blood | No random groups | 2026 |
| Glutamine-stimulated in vitro hypertrophy is preserved in muscle cells from older women.Mech Ageing Dev | No random groups | 2020 |
| Identification of human skeletal muscle miRNA related to strength by high-throughput sequencing.Physiol Genomics | No random groups | 2018 |
| Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.Clin Sci (Lond) | No random groups | 2017 |
| Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age.Poult Sci | No random groups | 2014 |
| Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations.Mech Ageing Dev | No random groups | 2012 |
| Four-year angiographic and intravascular ultrasound follow-up of patients treated with sirolimus-eluting stents.Circulation | No random groups | 2005 |
| Gene expression-based analysis identified NTNG1 and HGF as biomarkers for diabetic kidney disease.Medicine (Baltimore) | Group followed over time | 2020 |
| Outcomes of sirolimus regimens in 65-year-old and older kidney transplant recipients: a registry-based observational study.Int Urol Nephrol | Group followed over time | 2019 |
| Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis.Exp Gerontol | Group followed over time | 2018 |
| Unexpected Increase in Bone Mineral Density With Rapamycin and Low-Dose Naltrexone: A Case Report of a 52-Year-Old Woman With Osteopenia.Cureus | Case reports | 2025 |
| Exploring mTOR inhibition as treatment for mitochondrial disease.Ann Clin Transl Neurol | Case reports | 2019 |
| Pentadecanoic acid as a potential endogenous mTOR modulator for age-related female infertility: Mechanistic insights, molecular docking evidence, and therapeutic perspectives.J Steroid Biochem Mol Biol | Review of studies | 2027 |
| Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss.Med Gas Res | Review of studies | 2027 |
| Mitochondrial Microautophagy: An Emerging Pathway in Maintaining Mitochondrial Homeostasis.Antioxid Redox Signal | Review of studies | 2026 |
| Geroprotective Agents, Including Glucagon-Like Peptide-1 Receptor Agonists, for Ocular Health.J Ocul Pharmacol Ther | Review of studies | 2026 |
| Hemocytes as nutrient-sensing regulators of immune function, lifespan, and intergenerational fitness in Drosophila melanogaster.Dev Biol | Review of studies | 2026 |
| Beyond the cerebrospinal fluid: Preclinical and clinical evidence on central nervous system penetration and functional activity of oral rapamycin (sirolimus).J Alzheimers Dis | Review of studies | 2026 |
| Is there a role for senotherapeutics in the treatment of giant cell arteritis?Ageing Res Rev | Review of studies | 2026 |
| Caloric restriction mimetics rewire the AMPK-mTOR-ULK1 signaling nexus to restore autophagic proteostasis in the aging brain.Mol Cell Neurosci | Review of studies | 2026 |
| The potential role of the gephyrin-CNTNAP4 interface in brain aging: Mechanisms of inhibitory circuit dysfunction and cognitive decline.Prog Neuropsychopharmacol Biol Psychiatry | Review of studies | 2026 |
| Ginkgolide B as a Candidate Gerotherapeutic: Evidence, Evidentiary Limits, and Translational Requirements.Aging Dis | Review of studies | 2026 |
| Intermittent fasting: Impact, mechanisms and cautions across medical and lifestyle domains.Eur J Clin Nutr | Review of studies | 2026 |
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| Effects of nutritional interventions on biomarkers of cellular senescence in humans: A systematic review.Ageing Res Rev | Review of studies | 2026 |
| The orexinergic crossroads: Bidirectional links between sleep-wake disturbances and the pathogenesis of Alzheimer's disease in the aging brain.Sleep Med | Review of studies | 2026 |
| Metformin, SGLT2 Inhibitors, and Intermittent Fasting: Convergent Pathways to Healthspan Extension, Cardiovascular Longevity, and Cancer Prevention-A Narrative Review.Curr Issues Mol Biol | Review of studies | 2026 |
| Lysosomal Competence in Skeletal Muscle Aging: Autophagic Flux, Measurement Gaps, and Human Translation.Aging Dis | Review of studies | 2026 |
| Rapamycin across biology and medicine: From molecular mechanisms to clinical and translational frontiers.Biochim Biophys Acta Gen Subj | Review of studies | 2026 |
| Therapeutic Targeting of Inflammaging and Emerging Strategies for Managing Age-Related Multimorbidity: A Narrative Review.Clin Interv Aging | Review of studies | 2026 |
| mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes.Aging (Albany NY) | Review of studies | 2026 |
| Mitochondria-targeted therapeutic strategies in assisted reproduction: challenges and potential solutions.Hum Reprod | Review of studies | 2026 |
| Decoding the multidimensional landscape of skin aging: molecular pathways and next-generation diagnostics & therapeutics.Tissue Barriers | Review of studies | 2026 |
| Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy.Int J Mol Sci | Review of studies | 2026 |
| The Coupled Physico-Biochemical Mechanisms of Skin Aging: From Dermal Fluid Dynamics and Mechanotransduction to Nutrient-Sensing Dysfunction.Cureus | Review of studies | 2026 |
| Regulatory T cells in intracerebral hemorrhage: mechanisms of immunomodulation and therapeutic potential.Front Immunol | Review of studies | 2026 |
| Ex-Tregs: From controversial artifact to therapeutic target.Hlife | Review of studies | 2026 |
| Senotherapeutic strategies for ovarian aging: Mechanistic insights and translational perspectives.Curr Opin Pharmacol | Review of studies | 2026 |
| Caloric restriction rejuvenates aged adult stem cells: From mechanisms to interventions.Ageing Res Rev | Review of studies | 2026 |
| Pharmacological targeting of the senescence-associated secretory phenotype in atherosclerosis: therapeutic potential of senolytics and senomorphics.Naunyn Schmiedebergs Arch Pharmacol | Review of studies | 2026 |
| The metabolic-inflammatory axis in aging: A multi-organ framework anchored in Sarcopenia - A review.Arch Gerontol Geriatr | Review of studies | 2026 |
| Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK activation to SASP suppression.Mol Cell Endocrinol | Review of studies | 2026 |
| Mechanistic insights into aging and longevity: Implications for ovarian function and health.Tissue Cell | Review of studies | 2026 |
| A brief history of the hyperfunction theory of aging and future directions.Aging (Albany NY) | Review of studies | 2026 |
| Chasing the FoxO in Metabolic Disorders: Novel Considerations for Oxidative Stress, Programmed Cell Death, Wnt, and the Gut Microbiome.Antioxidants (Basel) | Review of studies | 2026 |
| Mechanistic intersections of empagliflozin and nebivolol in aging-associated redox and inflammatory pathways.Front Pharmacol | Review of studies | 2026 |
| Inflammaging: Experimental Insights and Translational Advances.Eur J Immunol | Review of studies | 2026 |
| Protein arginine methyltransferases coordinate mitochondrial stress adaptation and neuromuscular function.Exp Mol Med | Review of studies | 2026 |
| Targeted Treatment for Hyperuricemia: The Drug Pipeline.Drugs Aging | Review of studies | 2026 |
| Emerging pharmacotherapies for androgenetic alopecia.Expert Opin Pharmacother | Review of studies | 2026 |
| Molecular mechanisms of skeletal muscle atrophy: clinical challenges and future therapeutic strategies.Biochem Pharmacol | Review of studies | 2026 |
| Orchestration of Autophagy and Senescence: Kinases Take the Center Stage.Cells | Review of studies | 2026 |
| Post-transplant metabolic dysregulation: Insights and implications for kidney graft survival.World J Nephrol | Review of studies | 2026 |
| Unlocking the aging brain: mTORC1 as a convergent integrator for neurodegeneration and therapeutic intervention.Biogerontology | Review of studies | 2026 |
| Cross-Disorder Pruning-Plasticity-Aging Architecture in Substance Use Disorders and Anxiety: Transcriptome-Wide Association Insights and Mechanistic Synthesis.Cureus | Review of studies | 2026 |
| Technological Advances of Cryopreservation in Ovarian Tissue for Female Children: Exploring the Molecular Insights and Mechanisms.Int J Mol Sci | Review of studies | 2026 |
| Agitation, Alzheimer's disease, and autophagy: mechanistic insights into aging pathways, gut microbiome, and artificial intelligence.Front Immunol | Review of studies | 2026 |
| Longevity.Clin Med Res | Review of studies | 2026 |
| Insights into the therapeutic strategies for aging and aging-associated diseases.Signal Transduct Target Ther | Review of studies | 2026 |
| Bench to bedside: is rapamycin headed for the docTOR?Geroscience | Review of studies | 2026 |
| Why dietary interventions fail or succeed in ageing: Metabolic resilience as the missing integrative framework.Clin Nutr ESPEN | Review of studies | 2026 |
| Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans.Front Genet | Review of studies | 2026 |
| Symptom-Level Precision Neurology in Amyotrophic Lateral Sclerosis (ALS): Linking Microglial Pruning, Mitochondrial Nicotinamide Adenine Dinucleotide (NAD+) Compensation, and Autophagy Failure Across the Aging Spectrum.Cureus | Review of studies | 2026 |
| Antagonistic pleiotropy governing reproductive aging: evolutionary regulation of endometrial receptivity.Reproduction | Review of studies | 2026 |
| Control of muscle mass during growth and aging: Clinical targets and pathways.Best Pract Res Clin Endocrinol Metab | Review of studies | 2026 |
| Metformin beyond Glycemic Control: New Mechanistic Insights and Expanding Therapeutic Horizons.Diabetes Metab J | Review of studies | 2026 |
| Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1.Expert Rev Clin Pharmacol | Review of studies | 2026 |
| Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions.Int J Mol Sci | Review of studies | 2026 |
| SASP-driven vascular aging: unraveling the transcriptional nexus in endothelial senescence and cardiovascular disease.Histochem Cell Biol | Review of studies | 2026 |
| Targeting the senescence-autophagy axis for idiopathic pulmonary fibrosis therapy.Trends Pharmacol Sci | Review of studies | 2026 |
| More than Glucose Elimination: Additional Benefits of SGLT2 Inhibitors in Glomerular Diseases.Drugs | Review of studies | 2026 |
| Amino acid metabolism modulates chronic kidney disease progression by mediating the aging process: Mechanistic insights and therapeutic interventions.Diabetes Obes Metab | Review of studies | 2026 |
| The role of amino acid signaling in pathogenesis of chronic kidney disease.Mol Cell Biochem | Review of studies | 2026 |
| Unlocking the Secrets of Nature: Phytochemicals as Key Players in Longevity and Healthy Aging.Cell Biochem Biophys | Review of studies | 2026 |
| Redefining SGLT2 inhibitors through cytoprotective mechanisms.Eur J Pharmacol | Review of studies | 2026 |
| Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung.Eur J Pharmacol | Review of studies | 2026 |
| Dermal Fibroblast Senescence: The Central Hub of Skin Aging-From Intrinsic Dysfunction to Microenvironmental Remodeling.Int J Mol Sci | Review of studies | 2026 |
| Autophagy in kidney physiology: from cellular quality control to organ metabolism.Autophagy Rep | Review of studies | 2026 |
| Responses to nutrient starvation in the fission yeast Schizosaccharomyces pombe.Microbiol Res | Review of studies | 2026 |
| Risks and Benefits for Sirolimus in Aging Prevention.J Clin Pharmacol | Review of studies | 2026 |
| Kidney Disease as a Driver of Immunosenescence: Mechanisms and Potential Interventions.J Am Soc Nephrol | Review of studies | 2026 |
| Thyroid Hormones and Aging: Modulators of Mitochondrial Health, Metabolic Flexibility, and Longevity Pathways.Horm Metab Res | Review of studies | 2026 |
| Mechanistic Links Between the Gut Microbiome and Longevity Therapeutics.Biomedicines | Review of studies | 2026 |
| Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species.Front Genet | Review of studies | 2026 |
| The DNA Methylation-Autophagy Axis: A Driver of MSC Fate Imbalance in Skeletal Aging and Osteoporosis.Biology (Basel) | Review of studies | 2026 |
| The mTOR Pathway in Hearing Disorders: Mechanistic Links to Aging, Regeneration, and Neurodegeneration.Mol Neurobiol | Review of studies | 2026 |
| [Acquired pure red cell aplasia].Rinsho Ketsueki | Review of studies | 2026 |
| [The effect of geroprotectors on life expectancy: Mechanisms of action and clinical potential.].Adv Gerontol | Review of studies | 2026 |
| Aging reimagined: Bridging clinical modulation and scientific breakthroughs.Biol Sport | Review of studies | 2026 |
| Progress in anti-ageing drug research for age-related diseases: A review.Ageing Res Rev | Review of studies | 2026 |
| mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics.Signal Transduct Target Ther | Review of studies | 2025 |
| Clinical Strategies for Counteracting Human Ovarian Aging: Molecular Background, Update, and Outlook.Int J Mol Sci | Review of studies | 2025 |
| Drug-induced cutaneous toxicities in solid tumor oncology: mechanisms, manifestations, and management.Med Oncol | Review of studies | 2025 |
| The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity.Cureus | Review of studies | 2025 |
| Technology, pharmacology, and clinical outcomes of sirolimus coated balloons for peripheral arterial interventions.Expert Rev Med Devices | Review of studies | 2025 |
| Decoding ovarian aging in women: Cellular damage, signaling networks, and treatment frontiers.Reprod Biol | Review of studies | 2025 |
| Pathogens accelerate features of human aging: A review of molecular mechanisms.Ageing Res Rev | Review of studies | 2025 |
| AMPK/mTOR balance during exercise: implications for insulin resistance in aging muscle.Mol Cell Biochem | Review of studies | 2025 |
| The Role of Mammalian Target of Rapamycin (mTOR) and Adenosine Monophosphate-Activated Protein Kinase (AMPK) Signaling in Skeletal Muscle Hypertrophy: A Literature Review With Implications for Health and Disease.Cureus | Review of studies | 2025 |
| Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging.Inflammopharmacology | Review of studies | 2025 |
| Cardiac aging: Molecular mechanisms and therapeutic interventions.Pharmacol Res | Review of studies | 2025 |
| Cardiovascular Aging: From Molecular Mechanisms to Targeted Therapies.Mol Diagn Ther | Review of studies | 2025 |
| Antiaging agents: pharmacological therapy targeted at preserving skeletal muscle size and function in aging adults.Curr Opin Clin Nutr Metab Care | Review of studies | 2025 |
| Glucagon-like peptide-1 receptor agonists and muscle health: potential role in sarcopenia prevention and treatment.Eur J Endocrinol | Review of studies | 2025 |
| The role of the SIRT1 and mTOR pathways in exercise-induced β-cell senescence reduction in type 2 diabetes mellitus.Cell Mol Life Sci | Review of studies | 2025 |
| Adenosine Monophosphate-Activated Protein Kinase Activation and Mammalian Target of Rapamycin Complex 1 Inhibition: A Mechanistic Rationale for Anti-Aging Therapy in Type 2 Diabetes.J Clin Med Res | Review of studies | 2025 |
| Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.Int J Mol Sci | Review of studies | 2025 |
| Dietary and Pharmacological Modulation of Aging-Related Metabolic Pathways: Molecular Insights, Clinical Evidence, and a Translational Model.Int J Mol Sci | Review of studies | 2025 |
| Geroscience: A Translational Review.JAMA | Review of studies | 2025 |
| Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics.Drug Des Devel Ther | Review of studies | 2025 |
| Intensity, Duration, and Context Dependency of the Responses to Nutrient Surplus and Deprivation Signaling in the Heart: Insights Into the Complexities of Cardioprotection.Circulation | Review of studies | 2025 |
| Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1-Dependent Suppression of ROMK.Acta Physiol (Oxf) | In animals | 2026 |
| Tbx20 and Sirt1 synergize to ameliorate cardiac aging through enhanced autophagy.Tissue Cell | In animals | 2026 |
| Sodium arsenite accelerates aging of Caenorhabditis elegans parents and offspring through the insulin signaling pathway, oxidative stress, and autophagy.Ecotoxicol Environ Saf | In animals | 2026 |
| Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions.Biogerontology | In animals | 2026 |
| Dietary CoQ10 Ameliorates Age-Related Megakaryocyte Dysfunction via COPS3-Mediated Activation of Autophagy.Aging Cell | In animals | 2026 |
| Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila.Nature | In animals | 2026 |
| Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice.Aging Cell | In animals | 2026 |
| Evaluation the role of quinoa seeds in attenuation the brain cellular senescence and aging induced by D-galactose and γ-radiation in rats: insights into autophagy, telomerase activity, amyloid-β and tau proteins.Inflammopharmacology | In animals | 2026 |
| Pharmacological Activation of Autophagy Ameliorates Neuromuscular-Associated Defects and Extends Lifespan in a Caenorhabditis elegans Model of Spinal Muscular Atrophy.ACS Chem Neurosci | In animals | 2026 |
| LivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation.Aging Cell | In animals | 2026 |
| Effects of two longevity interventions, calorie restriction and rapamycin treatment, on the kynurenine-aryl hydrocarbon receptor pathway in aging skeletal muscle.Biochimie | In animals | 2026 |
| [Angelica sinensis promotes thymic cortical regeneration in mice with acute thymic involution induced by short-term rapamycin treatment].Zhejiang Da Xue Xue Bao Yi Xue Ban | In animals | 2026 |
| Constitutive mTORC1 activation in skeletal muscle increases inflammation but is not sufficient to impair glucose tolerance.Function (Oxf) | In animals | 2026 |
| The pyruvate transporter hermes regulates autophagy and health by modulating ROS production.Cell Rep | In animals | 2026 |
| Cell-based screen identifies translation state modulators that extend lifespan in Drosophila melanogaster and Caenorhabditis elegans.J Gerontol A Biol Sci Med Sci | In animals | 2026 |
| Cestode infection is linked to transcriptional shifts in neuropeptide signalling and caste-specific ageing pathways in a social insect.BMC Genomics | In animals | 2026 |
| Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.Nat Commun | In animals | 2026 |
| Leonurine-Standardized Leonurus japonicus Extract Promotes Recovery from Immobilization-Induced Muscle Atrophy via PI3K/Akt/mTOR Signaling in Mice.J Microbiol Biotechnol | In animals | 2026 |
| IPMK-1 governs C. elegans physiology through ceTOR but lifespan via a distinct IP3-dependent pathway.Mech Ageing Dev | In animals | 2026 |
| Fluphenazine, an antipsychotic compound, ameliorates Alzheimer's disease by clearing amyloid beta accumulation in C. elegans.Geroscience | In animals | 2026 |
| Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging.PLoS One | In animals | 2026 |
| Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice.J Gerontol A Biol Sci Med Sci | In animals | 2026 |
| 5-Hydroxytryptamine 2B receptor antagonism restores ATP and reduces tubulointerstitial fibrosis in the renal cortices of aged mice.J Pharmacol Exp Ther | In animals | 2026 |
| Hyperactive muscle mTORC1 attenuates functional adaptations to endurance training despite alterations in mitochondrial and lipid profiles.J Appl Physiol (1985) | In animals | 2026 |
| Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans.J Biomed Sci | In animals | 2026 |
| SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways.Drug Des Devel Ther | In animals | 2026 |
| Estradiol enhances influenza vaccine responses through B cell metabolic reprogramming in female mice.mBio | In animals | 2026 |
| Platelet mTOR Is a Regulator of Sterile Immunothrombosis.Arterioscler Thromb Vasc Biol | In animals | 2026 |
| Treatment of age-related decreases in GTP levels restores endocytosis and autophagy.Geroscience | In animals | 2026 |
| Cell-intrinsic mTOR/LET-363 influences morphological aging of the ALM touch receptor neuron in Caenorhabditis elegans.PLoS One | In animals | 2026 |
| Lung mTOR activation leads to lung fibrosis or emphysema via senescence of specific lung cells.Sci Rep | In animals | 2026 |
| Short-Term Rapamycin Mitigates the Senescence of Ovaries and Somatic Stem Cells in Multiple Organs in Reproductively Aged Mice.FASEB J | In animals | 2026 |
| No evidence for squaring the survival curve: lifespan-extending treatments increase variation in age- at-death.Biol Lett | In animals | 2026 |
| Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by Aging.Aging Cell | In animals | 2026 |
| Bioconverted Red Ginseng Protects Liver Functions and Alters Insulin Homeostasis-Associated Gut Microbiome Composition in Aged Mice.J Nutr | In animals | 2026 |
| Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models.J Adv Res | In animals | 2026 |
| Macelignan, a lignan from Myristica fragrans Houtt., rescues mitochondrial homeostasis and prevents cognitive decline in vascular dementia by modulating the mTOR-Mitophagy axis.J Ethnopharmacol | In animals | 2026 |
| Cellular survivorship bias as a mechanistic driver of muscle stem cell aging.Science | In animals | 2026 |
| CD36 regulates myogenic differentiation via chronic integrated stress response - implications for muscle aging.J Muscle Res Cell Motil | In animals | 2026 |
| Development of Insulin and Leptin Resistance in the Mouse Brainstem with Age.Mol Neurobiol | In animals | 2026 |
| Single-cell RNA sequencing analysis combined with bulk RNA sequencing revealed changes in the micro-environment of bone marrow aging.J Gerontol A Biol Sci Med Sci | In animals | 2026 |
| Integrative Omics Reveal Female-Specific Benefits of p16+ Cell Clearance in Aging Mice.Adv Sci (Weinh) | In animals | 2026 |
| Environmental factors accelerate epigenetic aging of sperm via mechanistic target of rapamycin/blood-testis barrier mechanism.F S Sci | In animals | 2026 |
| Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice.J Physiol | In animals | 2026 |
| Body-wide multi-omic counteraction of aging with GLP-1R agonism.Cell Metab | In animals | 2025 |
| Tetrahydroxy stilbene glucoside for alleviating osteoporosis: Elevating autophagy to attenuate osteoblast dysfunction mediated by the AMPK/mTOR/ULK1 pathway.Toxicol Appl Pharmacol | In animals | 2025 |
| Paternal iron deficiency and rapamycin supplementation influence antioxidants status, autophagy and lifespan in Drosophila melanogaster.J Trace Elem Med Biol | In animals | 2025 |
| The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection in Drosophila.Autophagy | In animals | 2025 |
| Rapamycin and Post-Deficiency Dietary Recovery Reshape Antioxidant Response and Survival in Offspring of Iron-Deficient Mothers.Biol Trace Elem Res | In animals | 2025 |
| Therapeutic potential of xanthohumol in senile osteoporosis: mTOR-driven regulation of AKT/mTOR/p70S6K autophagy axis in D-galactose models.Phytomedicine | In animals | 2025 |
| Aging influences nucleolar responses to traumatic brain injury in Drosophila.PLoS One | In animals | 2025 |
| Rescue of Aging-Dependent Reduction of Claudin-10b Expression by Glutamate in Mouse Intestinal MCE301 Cells.J Cell Biochem | In animals | 2025 |
| Tryptophan supplementation and high-intensity interval training prevent muscle atrophy and adipose tissue inflammation in high-fat-fed aged rats.Exp Gerontol | In animals | 2025 |
| Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice.Front Immunol | In animals | 2025 |
| Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice.Aging Cell | In animals | 2025 |
| Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways.Mol Neurobiol | In animals | 2025 |
| Lysosomes signal through the epigenome to regulate longevity across generations.Science | In animals | 2025 |
| Kinetics of thymic regeneration in female mice following short-term rapamycin administration.Eur J Pharmacol | In animals | 2025 |
| Impacts of a high-glucose diet or starvation on microRNA-transcription factor networks in Caenorhabditis elegans through Boolean mathematical modeling.Biosystems | In animals | 2025 |
| AKT2/mTOR/VEGF Signaling Attenuates Aging-Related Male Infertility by Suppressing Epididymal Autophagy and Apoptosis via Extracellular Vesicle-Mediated Sperm Rescue.FASEB J | In animals | 2025 |
| Sestrins regulate muscle stem cell metabolic homeostasis.Stem Cell Reports | In a lab dish | 2021 |
| Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture.J Ovarian Res | In a lab dish | 2021 |
| CREB activity is required for mTORC1 signaling-induced primordial follicle activation in mice.Histochem Cell Biol | In a lab dish | 2020 |
| The Effects of IL-1β on Astrocytes are Conveyed by Extracellular Vesicles and Influenced by Age.Neurochem Res | In a lab dish | 2020 |
| Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation.Aging (Albany NY) | In a lab dish | 2019 |
| Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells.PLoS One | In a lab dish | 2019 |
| Knockdown of insulin-like growth factor 1 exerts a protective effect on hypoxic injury of aged BM-MSCs: role of autophagy.Stem Cell Res TherRetracted | In a lab dish | 2018 |
| Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training.J Nutr | In a lab dish | 2018 |
| mTOR pathway activation drives lung cell senescence and emphysema.JCI Insight | In a lab dish | 2018 |
| MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling.J Cell Physiol | In a lab dish | 2018 |
| Celastrol alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy.Mol Med Rep | In a lab dish | 2017 |
| Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro.Biogerontology | In a lab dish | 2017 |
| Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.Aging Cell | In a lab dish | 2017 |
| Inhibition of mTOR induces a paused pluripotent state.Nature | In a lab dish | 2016 |
| Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts.Free Radic Biol Med | In a lab dish | 2016 |
| Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis.J Invest Dermatol | In a lab dish | 2016 |
| Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion.Theranostics | In a lab dish | 2016 |
| Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.Nat Commun | In a lab dish | 2015 |
| Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.J Gerontol A Biol Sci Med Sci | In a lab dish | 2015 |
| Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium.Exp Gerontol | In a lab dish | 2014 |
| Rapamycin induces pluripotent genes associated with avoidance of replicative senescence.Cell Cycle | In a lab dish | 2013 |
| Autophagy and apoptosis of recombinant Chinese hamster ovary cells during fed-batch culture: effect of nutrient supplementation.Biotechnol Bioeng | In a lab dish | 2011 |
| Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol.PLoS One | In a lab dish | 2011 |
| Autophagy impairment induces premature senescence in primary human fibroblasts.PLoS One | In a lab dish | 2011 |
| Acetaminophen improves protein translational signaling in aged skeletal muscle.Rejuvenation Res | In a lab dish | 2010 |
| Monitoring mammalian target of rapamycin (mTOR) activity.Methods Enzymol | In a lab dish | 2009 |
| Aging increases pulmonary veins arrhythmogenesis and susceptibility to calcium regulation agents.Heart Rhythm | In a lab dish | 2007 |
| Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice.J Gerontol A Biol Sci Med Sci | In a lab dish | 2005 |
| Rapamycin attenuates age-related atrial remodeling and fibrillation by targeting HIF-1α-mediated metabolic dysregulation.Biochim Biophys Acta Mol Basis Dis | Other paper | 2027 |
| Survey of the human proteostasis network: the autophagy-lysosome pathway.Autophagy | Other paper | 2026 |
| Ginsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation.Signal Transduct Target Ther | Other paper | 2026 |
| Human serum collected after fermented whey protein supplementation stimulates myocellular growth and protein synthesis: A randomized, double-blind, active-controlled crossover trial.Exp Gerontol | Other paper | 2026 |
| S-adenosyl-L-homocysteine triggers an adaptive response that extends lifespan through the YBT1 ABC transporter.Proc Natl Acad Sci U S A | Other paper | 2026 |
| Senescent cardiac cells promote thrombus formation and impair fibrinolysis.Geroscience | Other paper | 2026 |
| Feedback loops between DNMT1 and autophagy as well as senescence promotes organ aging and canities.Autophagy | Other paper | 2026 |
| Tissue-specific aging clocks map structured aging-modulatory drug-score patterns across 49 human tissue and cell-line categories.Biogerontology | Other paper | 2026 |
| Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis.Geroscience | Other paper | 2026 |
| Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.Signal Transduct Target Ther | Other paper | 2026 |
| Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans.MicroPubl Biol | Other paper | 2026 |
| Silibinin ameliorated lipid accumulation through insulin/IGF-1 signaling pathway in HGI Caenorhabditis elegans.J Nutr Biochem | Other paper | 2026 |
| Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: A pilot single-arm trial.J Cereb Blood Flow Metab | Other paper | 2026 |
| Activation of aryl hydrocarbon receptor by cigarette smoke induces oxidative stress, autophagy impairment and cellular senescence.Tob Induc Dis | Other paper | 2026 |
| Copper and iron engage distinct metabolic programs for cellular survival.Geroscience | Other paper | 2026 |
| mTOR drives cerebrovascular dysfunction and blood-brain barrier breakdown in a model of Alzheimers disease with cerebral amyloid angiopathy.bioRxiv | Other paper | 2026 |
| Exercise-Induced Activation of IGF-1/mTOR Signaling and Hippocampal BDNF/PGC-1α Expression Reverses Age-Related Motor Decline.Int Neurourol J | Other paper | 2026 |
| Plasma as Proxy for Tissue Metabolism When Extending Lifespan in Mice.Metabolites | Other paper | 2026 |
| Evaluation of Human Serum Albumin Nanoparticles for Rapamycin Delivery.ACS Omega | Other paper | 2026 |
| Pseudomonas aeruginosa infection causes lysosomal dysfunction in the cystic fibrosis bronchial epithelium.Infect Immun | Other paper | 2026 |
| Diet-dependent, beneficial and adverse effects of rapamycin on life span of Drosophila melanogaster.Geroscience | Other paper | 2026 |
| A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health.CPT Pharmacometrics Syst Pharmacol | Other paper | 2026 |
| Early life sugar rationing and ageing related diseases, biological ageing and mortality.Nat Commun | Other paper | 2026 |
| Apelin-13 prevents GATA4-mediated neuronal senescence by restoring autophagy through mTORC1 inhibition.Cell Death Dis | Other paper | 2026 |
| Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.Cureus | Other paper | 2026 |
| SELENOT, a Key Membrane-Bound Selenoprotein, Mediates Selenium's Protection Against Lead-Induced Renal Aging in Chickens by Modulating Inflammation and Autophagy.Biology (Basel) | Other paper | 2026 |
| The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities.Bioorg Chem | Other paper | 2026 |
| Multi-Tissue Metabolomic Signatures of Five Longevity Interventions Converge on Ergothioneine and Lipid Remodeling in Male UM-HET3 Mice.bioRxiv | Other paper | 2026 |
| Inhibitory effect of standardized Kaempferia parviflora extract on sarcopenia by improving protein metabolism pathways in aged C57BL/6J mice.J Tradit Complement Med | Other paper | 2026 |
| Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways.Aging Adv | Other paper | 2026 |
| An aging hallmark, Alzheimer's disease, and APOE nexus.J Alzheimers Dis | Other paper | 2026 |
| Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling.Phytomedicine | Other paper | 2026 |
| Matrix stiffness disrupts tight junction integrity in retinal pigment epithelial cells via YAP1-mediated autophagy suppression.Exp Cell Res | Other paper | 2026 |
| Mammalian aging involves genome-wide splicing degeneration leading to functional decline.bioRxiv | Other paper | 2026 |
| Chondroprotective Effects of Enzyme-Treated Extract from Cervus elaphus L. in a Rat Model of Osteoarthritis.Int J Mol Sci | Other paper | 2026 |
| Time-Restricted Feeding/Eating and Muscle Aging: Research Progress from Molecular Mechanisms to Personalized Intervention Strategies.Nutr Rev | Other paper | 2026 |
| YIF1A activates mTORC1 signaling to promote cellular senescence.Cell Death Dis | Other paper | 2026 |
| Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging.Aging Dis | Other paper | 2026 |
| Opposing Ageing-Related Transcriptomic Profiles Distinguish Opioid Exposure Liability From Dependence Liability.Cureus | Other paper | 2026 |
| Dark side of glial talk: Role of neuroinflammation in neurodegeneration.Neural Regen Res | Other paper | 2026 |
| Geroprotective interventions preserve trabecular bone during ageing in female mice.bioRxiv | Other paper | 2026 |
| Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions.Front Aging | Other paper | 2026 |
| Combined leucine supplementation and exercise to counteract sarcopenia in patients with end-stage kidney disease undergoing maintenance hemodialysis: a single-center randomized pilot study.Kidney Res Clin Pract | Other paper | 2026 |
| Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes.Elife | Other paper | 2026 |
| Short-term mTOR inhibition by rapamycin improves cardiac and endothelial function in older men: a proof-of concept pilot study.Geroscience | Other paper | 2026 |
| Effect of Branched-Chain Amino Acid Supplementation Alone or Combined With Tryptophan or Methionine on Appetite Control and Related Health Outcomes in Older Adults: Protocol for a Randomized Controlled Trial.JMIR Res Protoc | Other paper | 2026 |
| Type 2C protein phosphatases (PP2Cs) regulate cell proliferation in the yeast Saccharomyces cerevisiae.Mol Biol Rep | Other paper | 2026 |
| Descriptive Analysis of Adverse Drug Events of Three mTOR Inhibitors Using WHO-VigiAccess.Curr Drug Saf | Other paper | 2026 |
| Regulation of survival, growth, and metabolism by neuronal mTOR.Geroscience | Other paper | 2026 |
| Fisetin Attenuates D-Gal-Induced Ovarian Aging by Modulating Mitophagy via the AMPK/mTOR Pathway.Antioxidants (Basel) | Other paper | 2026 |
| Rapalink-1 Attenuates Oxidative-Stress-Induced Senescence in Vascular Cells in Association with Reduced NF-κB and MAPK Signaling.Biology (Basel) | Other paper | 2026 |
| Transcriptomics analyses reveal microgravity triggers estrogen synthesis amidst degeneration and aging in human ovarian granulosa cells.Life Sci Space Res (Amst) | Other paper | 2026 |
| Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β-TFEB signaling axis.Pharmacol Res | Other paper | 2026 |
| Novel Rapamycin Derivative With Lower Immunosuppressive Activity and Cytotoxicity Extends Lifespan of Caenorhabditis elegans.J Appl Toxicol | Other paper | 2026 |
| Smoke Condensate-Induced Vascular Senescence and SASP Are Attenuated by Dual mTORC1/2 Inhibition with Rapalink-1.Int J Mol Sci | Other paper | 2026 |
| Sirolimus and Mimetics: Modulator Sine Qua Non for Cardiac Xenotransplantation?FASEB J | Other paper | 2026 |
| A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket.bioRxiv | Other paper | 2026 |
| Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice.bioRxiv | Other paper | 2026 |
| Investigation of the Molecular Signature of Senescence in Mesenchymal Stem Cells.Avicenna J Med Biotechnol | Other paper | 2026 |
| The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset.J Alzheimers Dis Rep | Other paper | 2026 |