# NMN

nicotinamide mononucleotide · β-NMN

https://graded.pl/en/substances/nmn · Checked: Not yet

Preliminary version. The editors have not finished checking this card, and grades may change.

A substance the body turns into NAD+. Sold as a dietary supplement.

> This site is for information and education only. It does not promote or encourage the use or purchase of the substances described and is not medical advice. Many are not authorised as medicines and their safety has not been established. We sell nothing and have no ties to sellers. For health decisions, consult a doctor.

## Short answers

### Does NMN work?

A substance the body turns into NAD+. Sold as a dietary supplement. Longer life: grade C, not clear. Studies are short and measure NAD in blood or fitness tests, not ageing. One found better muscle response to insulin and another found no change.

### Is NMN legal?

PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. This covers medicines, not supplements. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). This covers medicines, not supplements. US: No approval. The FDA drug register has no such medicine.

### Is NMN banned in sport?

Not on the list, WADA 2026.

### Is NMN safe?

Little data. Studies last weeks, not years. A consulting firm reports that the EU food safety agency EFSA gave one NMN product a positive safety opinion on 11 May 2026, for adults, excluding pregnancy and breastfeeding. We have not read the opinion itself.

## What studies show

| | | | |
|---|---|---|---|
| Longer life | C | Not clear | Studies are short and measure NAD in blood or fitness tests, not ageing. One found better muscle response to insulin and another found no change. |

## Studies we have read

- Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. (GeroScience 2024; Random groups, n=60) https://pubmed.ncbi.nlm.nih.gov/38789831/
- The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. (GeroScience 2023; Random groups, n=80) https://pubmed.ncbi.nlm.nih.gov/36482258/
- Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study. (The Journal of clinical endocrinology and metabolism 2023; Random groups, n=30) https://pubmed.ncbi.nlm.nih.gov/36740954/
- Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. (Scientific reports 2023; Random groups, n=36) https://pubmed.ncbi.nlm.nih.gov/36797393/
- Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. (Science (New York, N.Y.) 2021; Random groups) https://pubmed.ncbi.nlm.nih.gov/33888596/

## Is it legal

- PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. This covers medicines, not supplements. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). This covers medicines, not supplements. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- US: No approval. The FDA drug register has no such medicine. https://www.accessdata.fda.gov/scripts/cder/daf/ (Checked: Not yet)

## Doping

Not on the list, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html

## How much research exists

- Scientific papers: 1555
- Studies with random groups: 17
- Registered studies in people: 33
- These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

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Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/