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The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
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MOTS-c

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Scientific papers

StudiesKind of studyYear
Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization.Med Sci Sports ExercRandom groups2025
Circulating levels of MOTS-c in patients with breast cancer treated with metformin.Aging (Albany NY)Random groups2022
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.J Appl Physiol (1985)Random groups2021
Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.Sci RepRandom groups2021
β-Amyloid and mitochondrial-derived peptide-c are additive predictors of adverse outcome to high-on-treatment platelet reactivity in type 2 diabetics with revascularized coronary artery disease.J Thromb ThrombolysisNo random groups2020
Effects of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes.J Am Heart AssocGroup followed over time2025
The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients: A Multicenter Cohort Study.Blood PurifGroup followed over time2024
Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.Curr RadiopharmGroup followed over time2024
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.Physiol IntReview of studies2026
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential.Eur J PharmacolReview of studies2026
Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility.Tissue CellReview of studies2026
Mitochondria-Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes.CellsReview of studies2026
Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.J Bioenerg BiomembrReview of studies2026
Emerging regulators of human physiology and disease; sORF-encoded microproteins.EpigenomicsReview of studies2026
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.Front ImmunolReview of studies2026
Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.Int J Pharm CompdReview of studies2026
MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases.J Transl MedReview of studies2026
Small but mighty: mitochondrial DNA at the centre of retrograde signalling.Cell Commun SignalReview of studies2026
Mitochondrial-derived microproteins in lung disease: insights and implications.Am J Physiol Lung Cell Mol PhysiolReview of studies2026
Next-generation therapies for hepatocellular carcinoma: CAR-T cell and anticancer peptide synergy.Int J Biol MacromolReview of studies2026
Mitochondria-derived peptides in liver disease: Emerging regulators of hepatic metabolism and therapeutic targets.Hepatol CommunReview of studies2026
Mitochondrial-derived microproteins in cancer and neurodegeneration: A new era of cross-disease mechanistic insights.Pathol Res PractReview of studies2026
Mitochondrial-Derived Peptides as Therapeutics and Biomarkers for Combating Vascular Aging and Associated Cardiovascular Diseases.Curr Cardiol RevReview of studies2026
MOTS-c in type 2 diabetes mellitus: From risk factors to cardiac complications and potential treatment.Life SciReview of studies2025
Mitochondrial-Derived Peptides: Implication in the Therapy of Neurodegenerative Diseases.Mol NeurobiolReview of studies2025
The unexplored Nexus: Mitochondria derived microproteins and Parkinson's disease.Pathol Res PractReview of studies2025
Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging.Pharmaceuticals (Basel)Review of studies2025
Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review).Mol Med RepReview of studies2025
The Role of Mitokines in Diabetic Nephropathy.Curr Med ChemReview of studies2025
Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities.J Adv ResReview of studies2024
The correlation between mitochondrial derived peptide (MDP) and metabolic states: a systematic review and meta-analysis.Diabetol Metab SyndrReview of studies2024
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives.PeptidesReview of studies2024
MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria.MitochondrionReview of studies2023
Exercise and vascular function in sedentary lifestyles in humans.Pflugers ArchReview of studies2023
Role of MOTS-c in the regulation of bone metabolism.Front PhysiolReview of studies2023
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.Diabetes Metab JReview of studies2023
Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases.Antioxidants (Basel)Review of studies2023
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.Front Endocrinol (Lausanne)Review of studies2023
Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases.Genes (Basel)Review of studies2023
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.J Transl MedReview of studies2023
MOTS-c Functionally Prevents Metabolic Disorders.MetabolitesReview of studies2023
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.Int J Mol SciReview of studies2022
Mitochondria-derived peptides in aging and healthspan.J Clin InvestReview of studies2022
Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c).Diabetes Metab JReview of studies2022
Cardio-protective role of Humanin in myocardial ischemia-reperfusion.Biochim Biophys Acta Gen SubjReview of studies2022
Mitochondrial-derived peptides: New markers for cardiometabolic dysfunction.Arch Cardiovasc DisReview of studies2022
Mitochondrial-Derived Peptides in Diabetes and Its Complications.Front Endocrinol (Lausanne)Review of studies2021
The emerging role of mitochondrial derived peptide humanin in the testis.Biochim Biophys Acta Gen SubjReview of studies2021
Mitochondrial-derived peptides and exercise.Biochim Biophys Acta Gen SubjReview of studies2021
The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets.Int J Mol SciReview of studies2021
[Effects of exercise intervention on mitochondrial-derived peptide MOTS-c in the germ cells of obese men].Zhonghua Nan Ke XueReview of studies2021
Mitochondrial-derived peptides in aging and age-related diseases.GeroscienceReview of studies2021
The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions.Genes (Basel)Review of studies2021
Mitochondrial-derived peptides in energy metabolism.Am J Physiol Endocrinol MetabReview of studies2020
Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.Redox BiolReview of studies2020
Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications.Exp Cell ResReview of studies2020
Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.Arch Cardiovasc DisReview of studies2020
Role of the mitochondrial stress response in human cancer progression.Exp Biol Med (Maywood)Review of studies2020
Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD.CellsReview of studies2020
MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.BioessaysReview of studies2019
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates.Biomed PharmacotherReview of studies2019
Mitochondrial peptides-appropriate options for therapeutic exploitation.Cell Tissue ResReview of studies2019
[The underestimated coding potential of mitochondrial DNA].Med Sci (Paris)Review of studies2019
Mitochondrial-Derived Peptides Exacerbate Senescence.Rejuvenation ResReview of studies2018
Mitochondrially derived peptides as novel regulators of metabolism.J PhysiolReview of studies2017
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.Free Radic Biol MedReview of studies2016
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model.Exp PhysiolIn animals2026
MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction.Life SciIn animals2026
MOTS-c preserves mitochondrial subpopulation bioenergetics and genome integrity to attenuate cardiac ischemia reperfusion injury.Mol Biol RepIn animals2026
Exogenous MOTS-c mitigates myocardial ischemia-reperfusion injury: experimental and in silico evidence from rat heart models.Naunyn Schmiedebergs Arch PharmacolIn animals2026
Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs.BMC Vet ResIn animals2026
A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure.Int J NeurosciIn animals2026
Therapeutic Effects of MOTS-c in the Valproic Acid-Induced Autism Model in Rats: Role of Tetrahydrobiopterin and Brain-Derived Neurotrophic Factor.Mol NeurobiolIn animals2026
MOTS-c primes adrenal cortex metabolism without directly driving steroidogenesis.Folia Histochem CytobiolIn animals2026
MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway.Protein Pept LettIn animals2026
The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension.J Muscle Res Cell MotilIn animals2025
MOTS-c modulates pancreatic islet function in rats and pigs in vitro.Histochem Cell BiolIn animals2025
MOTS-c Peptide Attenuated Diabetic Cardiomyopathy in STZ-Induced Type 1 Diabetic Mouse Model.Cardiovasc Drugs TherIn animals2025
MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3.Sci RepIn animals2025
MOTS-c Impact on Muscle Cell Differentiation and Metabolism Across Fiber Types.Cell Physiol BiochemIn animals2025
MOTS-c regulates the ROS/TXNIP/NLRP3 pathway to alleviate diabetic cardiomyopathy.Biochem Biophys Res CommunIn animals2024
Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.Reprod ToxicolIn animals2024
Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses.Drug Des Devel TherIn animals2024
An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand rats.Diabetes Res Clin PractIn animals2024
MOTS-c regulates pancreatic alpha and beta cell functions in vitro.Histochem Cell BiolIn animals2024
Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats.Neurosci LettIn animals2024
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.Am J Physiol Endocrinol MetabIn animals2024
The DNA-dependent protein kinase catalytic subunit exacerbates endotoxemia-induced myocardial microvascular injury by disrupting the MOTS-c/JNK pathway and inducing profilin-mediated lamellipodia degradation.TheranosticsIn animals2024
Central and peripheral mechanism of MOTS-c attenuates pain hypersensitivity in a mice model of inflammatory pain.Neurol ResIn animals2024
Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial biogenesis.Mol PainIn animals2024
The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury.Sci RepIn animals2023
The Mitochondrial-Derived Peptide (MOTS-c) Interacted with Nrf2 to Defend the Antioxidant System to Protect Dopaminergic Neurons Against Rotenone Exposure.Mol NeurobiolIn animals2023
Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.Sci RepIn animals2023
Β-GPA administration activates slow oxidative muscle signaling pathways and protects soleus muscle against the increased fatigue under 7-days of rat hindlimb suspension.Arch Biochem BiophysIn animals2023
Mitochondrial-Derived Peptide MOTS-c Ameliorates Spared Nerve Injury-Induced Neuropathic Pain in Mice by Inhibiting Microglia Activation and Neuronal Oxidative Damage in the Spinal Cord via the AMPK Pathway.ACS Chem NeurosciIn animals2023
Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins.Biol FuturIn animals2023
The specific mitochondrial unfolded protein response in fast- and slow-twitch muscles of high-fat diet-induced insulin-resistant rats.Front Endocrinol (Lausanne)In animals2023
MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats.Life SciIn animals2023
Orally administered MOTS-c analogue ameliorates dextran sulfate sodium-induced colitis by inhibiting inflammation and apoptosis.Eur J PharmacolIn animals2023
Mitochondrial derived peptide MOTS-c prevents the development of heart failure under pressure overload conditions in mice.J Cell Mol MedIn animals2022
The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways.Cardiovasc Eng TechnolIn animals2022
MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose.Physiol RepIn animals2022
MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.Front Endocrinol (Lausanne)In animals2022
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.Pharmacol ResIn animals2022
Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM2.5.Front Endocrinol (Lausanne)In animals2021
The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats.Sci RepIn animals2021
MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway.Biochim Biophys Acta Mol Basis DisIn animals2021
MOTS-c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice.EMBO Mol MedIn animals2021
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism.Cell MetabIn animals2021
Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1-SIRT1-PGC-1α.DiabetologiaIn animals2020
Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice.Int ImmunopharmacolIn animals2020
Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway.Cardiorenal MedIn animals2020
MOTS-c accelerates bone fracture healing by stimulating osteogenesis of bone marrow mesenchymal stem cells via positively regulating FOXF1 to activate the TGF-β pathway.Eur Rev Med Pharmacol SciRetractedIn animals2019
MOTS-c inhibits Osteolysis in the Mouse Calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation.Pharmacol ResIn animals2019
The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.Physiol RepIn animals2019
Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c.Biochem Biophys Res CommunIn animals2019
Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation.Int J Mol SciIn animals2019
MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway.Eur Rev Med Pharmacol SciIn animals2018
MOTS-c peptide increases survival and decreases bacterial load in mice infected with MRSA.Mol ImmunolIn animals2017
Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation.Biochem Biophys Res CommunIn animals2016
The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro.MitochondrionIn a lab dish2021
Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction.Int J CardiolIn a lab dish2018
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.Bioact MaterOther paper2027
MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study.Int Urol NephrolOther paper2026
Mots-c attenuates diabetic nephropathy by downregulating LARS1 to promote lipophagy and suppress tubular senescence.Biochem PharmacolOther paper2026
Integrative transcriptomic and computational analysis associates Ms4a6c+ macrophages with fibrosis in radiation proctitis and computationally nominates MOTS-c as a candidate modulator.Front ImmunolOther paper2026
Associations of Serum MOTS-c with Exercise Capacity and Antioxidant Markers in Young Males: A Cross-Sectional Study.Antioxidants (Basel)Other paper2026
The mitochondrial-derived peptide MOTS-c improves bioenergetics in aging-associated granulosa cells and oocytes.Reprod FertilOther paper2026
MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.AutophagyOther paper2026
MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis.Chin Med J (Engl)Other paper2026
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.ElifeOther paper2026
Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.Exp PhysiolOther paper2026
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.Antioxidants (Basel)Other paper2026
MOTS-c attenuates placental vascular endothelial cell apoptosis in intrahepatic cholestasis of pregnancy by inhibiting K33-linked deubiquitination of BACH1.Cell Commun SignalOther paper2026
LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation and mitochondrial protection.Redox BiolOther paper2026
Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis.Free Radic Biol MedOther paper2026
Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells.Inflamm RegenOther paper2026
MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia.Front Med (Lausanne)Other paper2026
Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study.J Clin MedOther paper2026
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.BiomedicinesOther paper2026
The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study.BiomedicinesOther paper2026
Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?Arch Endocrinol MetabOther paper2026
MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy.Free Radic Biol MedOther paper2026
Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway.Eur J PharmacolOther paper2026
MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.Free Radic Biol MedOther paper2026
Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.Sci RepOther paper2026
Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway.Front Endocrinol (Lausanne)Other paper2026
Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.Physiol RepOther paper2026
Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss.J Clin Transl EndocrinolOther paper2026
Muscle-Targeted Nanocomposite Therapy Alleviates Age-Related Sarcopenia via Antioxidant and Metabolic Reprogramming.ACS NanoOther paper2026
Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients.Kidney Blood Press ResOther paper2026
MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice.Int J Mol MedOther paper2026
Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.J Am Heart AssocOther paper2025
MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent Mechanism.Free Radic Biol MedOther paper2025
Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis.CureusOther paper2025
Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.Int J Mol SciOther paper2025
Hierarchical random forest model, inflammation and oxidative stress as predictors of the atherogenic index of plasma and diabetes progression.Sci RepOther paper2025
MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction.Arch Endocrinol MetabOther paper2025
MOTS-c Promotes Glycolysis via AMPK-HIF-1α-PFKFB3 Pathway to Ameliorate Cardiopulmonary Bypass-induced Lung Injury.Am J Respir Cell Mol BiolOther paper2025
MOTS-c attenuates airway barrier dysfunction in allergic asthma by inhibiting epithelial apoptosis via Nrf2 pathway.Int ImmunopharmacolOther paper2025
Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.Clin Exp MedOther paper2025
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes.Exp Mol MedOther paper2025
Characterization of the Avian Mitochondrial-Derived Peptide MOTS-c and Its Potential Role as a Metabolic Regulator.Animals (Basel)Other paper2025
Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea.Sleep Biol RhythmsOther paper2025
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.Redox BiolOther paper2025
Mitochondria-derived peptide MOTS-c restores mitochondrial respiration in type 2 diabetic heart.Front PhysiolOther paper2025
MOTS-c-modified functional self-assembly peptide hydrogels enhance the activity of nucleus pulposus-derived mesenchymal stem cells of intervertebral disc degeneration.Mater Today BioOther paper2025
Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD.JHEP RepOther paper2025
Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?J Clin Res Pediatr EndocrinolOther paper2025
Circulating mitochondrial biomarkers in acute coronary syndrome.Front Med (Lausanne)Other paper2025
Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement.BiologicsOther paper2025
MOTS-c mimics remote ischemic preconditioning in protecting against lung ischemia-reperfusion injury by alleviating endothelial barrier dysfunction.Free Radic Biol MedOther paper2025
Exploring the therapeutic potential of MOTS-c in age-related macular degeneration: from cellular responses to patient-derived cybrids.Hum CellOther paper2025
MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study.Medicina (Kaunas)Other paper2025
Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion.Free Radic Biol MedOther paper2025
MOTS-c as a Potential Diagnostic-prognostic Biomarker for Myocardial Infarction.Cardiovasc Hematol Agents Med ChemOther paper2025

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Registered studies in people (4)