| Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.Urology | Random groups | 2000 |
| Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.Int J Impot Res | No random groups | 2000 |
| Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.J Urol | No random groups | 1998 |
| Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.Life Sci | No random groups | 1996 |
| A glimpse into the underground market of melanotan.Dermatol Online J | Group followed over time | 2018 |
| Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report.Life (Basel) | Case reports | 2026 |
| Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?Int J Oral Maxillofac Surg | Case reports | 2025 |
| [The risks of tanning with the Barbie drug].Ned Tijdschr Geneeskd | Case reports | 2022 |
| Melanotan Tanning Injection: A Rare Cause of Priapism.Sex Med | Case reports | 2021 |
| Melanotan II: a possible cause of renal infarction: review of the literature and case report.CEN Case Rep | Case reports | 2020 |
| [Eruptive nevi after injection of drugs marketed as melanotan II. The first two Swedish cases described].Lakartidningen | Case reports | 2013 |
| [Dermoscopic changes in melanocytic nevi during use of melanotan II].Hautarzt | Case reports | 2012 |
| Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.Sex Med Rev | Review of studies | 2026 |
| Falsification of biotechnology drugs: current dangers and/or future disasters?J Pharm Biomed Anal | Review of studies | 2018 |
| Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies.Expert Opin Investig Drugs | Review of studies | 2014 |
| Recent advances in porous silicon technology for drug delivery.Ther Deliv | Review of studies | 2013 |
| Sympathetic and sensory innervation of brown adipose tissue.Int J Obes (Lond) | Review of studies | 2010 |
| Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.Peptides | Review of studies | 2006 |
| Discovery that a melanocortin regulates sexual functions in male and female humans.Peptides | Review of studies | 2005 |
| Central nervous system agents in the treatment of erectile dysfunction: how do they work?Curr Urol Rep | Review of studies | 2001 |
| Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.Eur J Pharmacol | In animals | 2024 |
| Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.Mol Cell Endocrinol | In animals | 2024 |
| Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.Endocrinology | In animals | 2024 |
| Melanotan-II reverses memory impairment induced by a short-term HF diet.Biomed Pharmacother | In animals | 2023 |
| Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.Neuropeptides | In animals | 2022 |
| Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus.Peptides | In animals | 2021 |
| The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections.Nutrients | In animals | 2021 |
| Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice.Exp Physiol | In animals | 2021 |
| Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.Am J Physiol Endocrinol Metab | In animals | 2021 |
| CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice.Neurosci Lett | In animals | 2020 |
| Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II.Anal Chim Acta | In animals | 2020 |
| Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.Mol Metab | In animals | 2020 |
| Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors.Mol Metab | In animals | 2020 |
| Sites and sources of sympathoexcitation in obese male rats: role of brain insulin.Am J Physiol Regul Integr Comp Physiol | In animals | 2020 |
| Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism.PLoS One | In animals | 2019 |
| Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss.Am J Physiol Regul Integr Comp Physiol | In animals | 2018 |
| Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.Am J Physiol Endocrinol Metab | In animals | 2018 |
| The stimulatory G protein Gsα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.J Biol Chem | In animals | 2018 |
| Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors.Obesity (Silver Spring) | In animals | 2018 |
| Control of appetite, blood glucose, and blood pressure during melanocortin-4 receptor activation in normoglycemic and diabetic NPY-deficient mice.Am J Physiol Regul Integr Comp Physiol | In animals | 2018 |
| Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.Can J Physiol Pharmacol | In animals | 2018 |
| AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting.Endocrinology | In animals | 2017 |
| Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.Can J Physiol Pharmacol | In animals | 2017 |
| Effect of Melanotan-II on Brain Fos Immunoreactivity and Oxytocin Neuronal Activity and Secretion in Rats.J Neuroendocrinol | In animals | 2017 |
| Ventromedial hypothalamic melanocortin receptor activation: regulation of activity energy expenditure and skeletal muscle thermogenesis.J Physiol | In animals | 2016 |
| Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.J Clin Invest | In animals | 2016 |
| Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice.Addict Biol | In animals | 2016 |
| Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria.Diabetes | In animals | 2016 |
| [STUDYING THE ROLE OF BRAIN MELANOCORTIN RECEPTORS IN THE SUPPRESSING OF FOOD INTAKE UNDER ETHER STRESS IN MICE].Ross Fiziol Zh Im I M Sechenova | In animals | 2015 |
| Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.Mol Endocrinol | In animals | 2015 |
| Role of the Paraventricular Nucleus of the Hypothalamus in the Sympathoexcitatory Effects of Leptin.Hypertension | In animals | 2015 |
| Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice.Physiol Behav | In animals | 2015 |
| Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus.PLoS One | In animals | 2015 |
| Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice.Alcohol Clin Exp Res | In animals | 2015 |
| The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles.Transl Psychiatry | In animals | 2015 |
| Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole.Neuropsychopharmacology | In animals | 2015 |
| Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin.Protein Pept Lett | In animals | 2015 |
| Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes.Endocrinology | In animals | 2014 |
| Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner.Neuropharmacology | In animals | 2014 |
| Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.J Neurosci | In animals | 2014 |
| The PVH as a site of CB1-mediated stimulation of thermogenesis by MC4R agonism in male rats.Endocrinology | In animals | 2014 |
| The medial preoptic nucleus as a site of the thermogenic and metabolic actions of melanotan II in male rats.Am J Physiol Regul Integr Comp Physiol | In animals | 2014 |
| Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice.Arterioscler Thromb Vasc Biol | In animals | 2014 |
| Central mechanisms of adiposity in adult female mice with androgen excess.Obesity (Silver Spring) | In animals | 2014 |
| Pain reduces sexual motivation in female but not male mice.J Neurosci | In animals | 2014 |
| The protective effects of the melanocortin receptor (MCR) agonist, melanotan-II (MTII), against binge-like ethanol drinking are facilitated by deletion of the MC3 receptor in mice.Neuropeptides | In animals | 2014 |
| Melanocortin 4 receptors in the paraventricular nucleus modulate the adipose afferent reflex in rat.PLoS One | In animals | 2013 |
| Adolescent binge-like ethanol exposure reduces basal α-MSH expression in the hypothalamus and the amygdala of adult rats.Pharmacol Biochem Behav | In animals | 2013 |
| Melanocortin signaling in the brainstem influences vagal outflow to the stomach.J Neurosci | In animals | 2013 |
| Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.Exp Physiol | In animals | 2013 |
| Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.Am J Physiol Regul Integr Comp Physiol | In animals | 2012 |
| Hemodynamic actions and mechanisms of systemically administered α-MSH analogs in mice.Peptides | In animals | 2012 |
| Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.Am J Physiol Endocrinol Metab | In animals | 2012 |
| Region-specific differences in brain melanocortin receptors in rats of the lean phenotype.Neuroreport | In animals | 2012 |
| Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.Obesity (Silver Spring) | In animals | 2012 |
| The anorectic effect of GLP-1 in rats is nutrient dependent.PLoS One | In animals | 2012 |
| CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.Diabetes | In animals | 2011 |
| Anatomical dissociation of melanocortin receptor agonist effects on taste- and gut-sensitive feeding processes.Am J Physiol Regul Integr Comp Physiol | In animals | 2011 |
| Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis.Brain Res | In animals | 2011 |
| Assessment of voluntary ethanol consumption and the effects of a melanocortin (MC) receptor agonist on ethanol intake in mutant C57BL/6J mice lacking the MC-4 receptor.Alcohol Clin Exp Res | In animals | 2011 |
| Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons.J Neurosci | In a lab dish | 2008 |
| Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons.J Neurosci | In a lab dish | 2008 |
| Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO.Br J Pharmacol | In a lab dish | 2001 |
| A comparison of HPLC and bioassay methods for plasma melanotan-II (MT-II) determination: application to a pharmacokinetic study in rats.Biopharm Drug Dispos | In a lab dish | 1994 |
| Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).ACS Pharmacol Transl Sci | Other paper | 2024 |
| 5-Hydroxypyrroloindoline Affords Tryptathionine and 2,2'-bis-Indole Peptide Staples: Application to Melanotan-II.Chemistry | Other paper | 2024 |
| Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner.Neuropharmacology | Other paper | 2024 |
| Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.Mol Metab | Other paper | 2023 |
| Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons.Curr Biol | Other paper | 2022 |
| CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.J Med Chem | Other paper | 2022 |
| A sentinel population: The public health benefits of monitoring enhanced body builders.Int J Drug Policy | Other paper | 2021 |
| Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity.Int J Mol Sci | Other paper | 2021 |
| Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish.Biomedicines | Other paper | 2021 |
| LC-HRMS characterization of the skin pigmentation and sexual enhancers melanotan II and bremelanotide sold on the black market of performance and image enhancing drugs.Drug Test Anal | Other paper | 2021 |
| Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.JCI Insight | Other paper | 2021 |
| Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System.JACC Basic Transl Sci | Other paper | 2021 |
| Melanotan II User Experience: A Qualitative Study of Online Discussion Forums.Dermatology | Other paper | 2021 |
| Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.ACS Pharmacol Transl Sci | Other paper | 2020 |
| Application of Dimedone Enamines as Protecting Groups for Amines and Peptides.Org Lett | Other paper | 2020 |
| Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition.Int J Mol Sci | Other paper | 2020 |
| Glucose-regulated protein 78 binds to and regulates the melanocortin-4 receptor.Exp Mol Med | Other paper | 2018 |
| Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe.Drug Test Anal | Other paper | 2016 |
| Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.Front Behav Neurosci | Other paper | 2015 |
| Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons.Eur J Neurosci | Other paper | 2014 |
| Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area.J Comp Neurol | Other paper | 2012 |
| Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.Peptides | Other paper | 2010 |
| I. Slow oscillations in vaginal blood flow: alterations during sexual arousal in rodents and humans.J Sex Med | Other paper | 2010 |
| Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.Peptides | Other paper | 2009 |
| Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells.Anal Biochem | Other paper | 2009 |
| The first preparative solution phase synthesis of melanotan II.Beilstein J Org Chem | Other paper | 2008 |
| Interconnection between orexigenic neuropeptide Y- and anorexigenic alpha-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus.Brain Res | Other paper | 2006 |
| Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.Endocrinology | Other paper | 2005 |
| Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity.J Clin Endocrinol Metab | Other paper | 2005 |
| Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides.Eur J Pharmacol | Other paper | 2004 |
| [Therapy of erectile dysfunction in 2005].Urologe A | Other paper | 2003 |
| Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.Eur J Pharmacol | Other paper | 1999 |
| American Urological Association--94th annual meeting. 1-6 May 1999, Dallas, USA.IDrugs | Other paper | 1999 |