| Peptides in Aesthetic Dermatology: Classification, Fibroblast-Centered Mechanisms, Delivery Technologies, and Clinical Evidence.Life (Basel) | Review of studies | 2026 |
| GHK-Cu as a Bioactive Metallopeptide and Drug-Delivery Cargo: Coordination Chemistry, Formulation Science, Therapeutic Evidence, and a Translational Roadmap.Pharmaceutics | Review of studies | 2026 |
| Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.Curr Pain Headache Rep | Review of studies | 2026 |
| Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.Int J Mol Sci | Review of studies | 2026 |
| Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.Front Aging | Review of studies | 2026 |
| Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res Rev | Review of studies | 2026 |
| Smart Healing for Wound Repair: Emerging Multifunctional Strategies in Personalized Regenerative Medicine and Their Relevance to Orthopedics.Antibiotics (Basel) | Review of studies | 2026 |
| Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.Am J Sports Med | Review of studies | 2026 |
| Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.Bioimpacts | Review of studies | 2025 |
| Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?Molecules | Review of studies | 2025 |
| Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.Int J Mol Sci | Review of studies | 2018 |
| The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.Oxid Med Cell Longev | Review of studies | 2012 |
| The human tri-peptide GHK and tissue remodeling.J Biomater Sci Polym Ed | Review of studies | 2008 |
| A tea exosome-integrated self‑oxygenating cascade chitosan/oxidized alginate hydrogel for remodeling the hyperglycemic and hypoxic microenvironment in diabetic wound healing.Carbohydr Polym | In animals | 2026 |
| Water-Soluble, Enzyme-Degradable, and Hydrolyzable STAR Particles for Enhanced Drug Delivery to Skin.Adv Healthc Mater | In animals | 2026 |
| Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) Attenuates CuSO4 or LPS induced-inflammation in Zebrafish larvae model.Eur J Pharmacol | In animals | 2026 |
| The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways.Biogerontology | In animals | 2026 |
| An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant.Colloids Surf B Biointerfaces | In animals | 2025 |
| Expression and Purification of Recombinant GHK Tripeptides Are Able to Protect against Acute Cardiotoxicity from Exposure to Waterborne-Copper in Zebrafish.Biomolecules | In animals | 2020 |
| Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways.Life Sci | In animals | 2020 |
| Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity.Mater Sci Eng C Mater Biol Appl | In animals | 2019 |
| The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.Oncotarget | In animals | 2016 |
| Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction.J Orthop Res | In animals | 2015 |
| Effects of topical copper tripeptide complex on wound healing in an irradiated rat model.Otolaryngol Head Neck Surg | In animals | 2013 |
| The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures.Life Sci | In animals | 2000 |
| In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds.J Clin Invest | In animals | 1993 |
| Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation.Adv Exp Med Biol | In animals | 1990 |
| Hierarchical regulation and mechanism of "open-hollow-fibrous network" structures: Osteogenic-angiogenic coupling responses of poly(γ-benzyl-L-glutamate) microspheres.Biomater Adv | In a lab dish | 2026 |
| Microneedle-Mediated Delivery of Copper Peptide Through Skin.Pharm Res | In a lab dish | 2015 |
| Effect of GLY-HIS-LYS and its copper complex on TGF-β secretion in normal human dermal fibroblasts.Acta Pol Pharm | In a lab dish | 2014 |
| Characterization of copper tripeptide-loaded lipid carriers and their stability in complex cosmetic matrices.J Chromatogr A | Other paper | 2026 |
| Microenvironment-responsive injectable dynamic hydrogel for sequential antioxidant and tissue regeneration therapy of radiation-induced skin injury.Bioact Mater | Other paper | 2026 |
| The Regenerative Potential of GHK-Cu in Aesthetic Medicine.Aesthet Surg J | Other paper | 2026 |
| Peptide Supplements and Their Therapeutic Applications in Sports Medicine.Am J Sports Med | Other paper | 2026 |
| Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu.Skin Res Technol | Other paper | 2026 |
| Copper peptide activated cascade catalysis for glucose regulation and hypoxia reversing in infected diabetic wound healing.Mater Today Bio | Other paper | 2026 |
| A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials.Arch Intern Med Res | Other paper | 2026 |
| A Torilis japonica Extract-GHK-Cu Complex Attenuates Th2 Cytokines and Promotes Keratinocyte Recovery: A Potential Antioxidant Strategy for Atopic Dermatitis.Antioxidants (Basel) | Other paper | 2026 |
| Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs.Res Sq | Other paper | 2026 |
| Copper(II)-Tripeptide Complexes as Potential Skin Healing Agents: Synthesis, Characterization, and Wound Repair Ability.ChemMedChem | Other paper | 2026 |
| Multi-Target Restoration of Dermal Elastic Fibers Through Elastin Upregulation, Elastase Suppression, and Scaffold Reinforcement.Curr Issues Mol Biol | Other paper | 2026 |
| The Laccase-like Property of GHK-Cu and Its Applications in Colorimetric Sensing of Phenolic Compounds.Biosensors (Basel) | Other paper | 2026 |
| Golgi-targeted copper delivery strategy via enhancing copper-dependent proteins' activity for fascia regeneration.J Control Release | Other paper | 2026 |
| Efficacy and Safety Assessment of ThriveCo Scar Fader Gel With Scarcede™ in the Treatment of Skin Scars.Cureus | Other paper | 2025 |
| Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms.Front Pharmacol | Other paper | 2025 |
| Intramolecular Charge Transfer-Induced Fluorescent Probe for the Sensitive Detection of Copper Tripeptide.J Phys Chem B | Other paper | 2025 |
| Copper Complexes with New Glycyl-l-histidyl-l-lysine-Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects.Bioconjug Chem | Other paper | 2025 |
| Food-Derived Tripeptide-Copper Self-Healing Hydrogel for Infected Wound Healing.Biomater Res | Other paper | 2025 |
| Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines.Biochem Biophys Res Commun | Other paper | 2025 |
| Novel Applications of CE-ICP-MS/MS: Monitoring of Antiaging GHK-Cu Cosmetic Component Encapsulation in Liposomes.Electrophoresis | Other paper | 2024 |
| An Assessment of the Safety, Efficacy, and Tolerability of a Novel Scalp Treatment Regimen Combining a Hydroxy Acid-Based Scrub and Copper Tripeptide Serum in the Management of Seborrheic Dermatitis in Adults.Cureus | Other paper | 2024 |
| The glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6.Redox Biol | Other paper | 2024 |
| Rigid-flexible nanocarriers loaded with active peptides for antioxidant and anti-inflammatory applications in skin.Colloids Surf B Biointerfaces | Other paper | 2024 |
| Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application.Bioact Mater | Other paper | 2024 |
| Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide.Aging Pathobiol Ther | Other paper | 2024 |
| Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide.bioRxiv | Other paper | 2023 |
| Intranasal GHK peptide enhances resilience to cognitive decline in aging mice.bioRxiv | Other paper | 2023 |
| Phenothiazine-Based Cu(II)-Selective Fluorescent Sensor: GHK-Cu Sensing Applications.J Org Chem | Other paper | 2023 |
| Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.Pharmaceutics | Other paper | 2023 |
| Effect of Peptides on the Synthesis, Properties and Wound Healing Capacity of Silver Nanoparticles.Pharmaceutics | Other paper | 2023 |
| Ultrasensitive and Label-Free Detection of Copper Ions by GHK-Modified Asymmetric Nanochannels.Anal Chem | Other paper | 2023 |
| Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.J Cosmet Dermatol | Other paper | 2023 |
| Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex via activation of SIRT1 in airway epithelial cells.Biomed Pharmacother | Other paper | 2023 |
| Multi working mode SPR chip laboratory for high refractive index detection.Opt Express | Other paper | 2023 |
| Glycyl-l-histidyl-l-lysine-Cu2+ rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.J Cachexia Sarcopenia Muscle | Other paper | 2023 |
| Improved laccase production by Trametes versicolor using Copper-Glycyl-L-Histidyl-L-Lysine as a novel and high-efficient inducer.Front Bioeng Biotechnol | Other paper | 2023 |
| Differential Effects of Histidine and Histidinamide versus Cysteine and Cysteinamide on Copper Ion-Induced Oxidative Stress and Cytotoxicity in HaCaT Keratinocytes.Antioxidants (Basel) | Other paper | 2023 |
| Glycyl-L-histidyl-L-lysine-Cu2+ attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway.Front Mol Biosci | Other paper | 2022 |
| Polyaspartic acid, 2-acrylamido-2-Methyl propane sulfonic acid and sodium alginate based biocompatible stimuli responsive polymer gel for controlled release of GHK-Cu peptide for wound healing.J Biomater Appl | Other paper | 2022 |
| Cutaneous Delivery of Cosmeceutical Peptides Enhanced by Picosecond- and Nanosecond-Domain Nd:YAG Lasers with Quick Recovery of the Skin Barrier Function: Comparison with Microsecond-Domain Ablative Lasers.Pharmaceutics | Other paper | 2022 |
| Efficient Ternary Polymer Solar Cells with Tunable Crystallinity and Phase Separation of Active Layers via Incorporating GHK-Cu.ACS Appl Mater Interfaces | Other paper | 2021 |
| One-Pot Synthesis-Biocompatible Copper-Tripeptide Complex as a Nanocatalytic Medicine to Enhance Chemodynamic Therapy.ACS Biomater Sci Eng | Other paper | 2021 |
| Coassemble dopamine and GHK tripeptide into fluorescent nanoparticles for pH sensing.Luminescence | Other paper | 2021 |
| Enhanced angiogenic effects of RGD, GHK peptides and copper (II) compositions in synthetic cryogel ECM model.Mater Sci Eng C Mater Biol Appl | Other paper | 2021 |
| Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.Int J Mol Sci | Other paper | 2020 |
| QR678 & QR678 Neo Hair Growth Formulations: A Cellular Toxicity & Animal Efficacy Study.Plast Reconstr Surg Glob Open | Other paper | 2020 |
| Enhanced biological properties of collagen/chitosan-coated poly(ε-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass.Prog Biomater | Other paper | 2020 |
| Copper-tripeptides (cuzymes) with peroxidase-mimetic activity.RSC Adv | Other paper | 2020 |
| The potential of GHK as an anti-aging peptide.Aging Pathobiol Ther | Other paper | 2020 |
| Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide.J Pept Sci | Other paper | 2020 |
| In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer.ACS Omega | Other paper | 2019 |
| Chelating Surfaces for Oriented Human Serum Albumin Molecules.Langmuir | Other paper | 2019 |
| Intradermal injections of a hair growth factor formulation for enhancement of human hair regrowth - safety and efficacy evaluation in a first-in-man pilot clinical study.J Cosmet Laser Ther | Other paper | 2018 |
| Androgenetic Alopecia Treatment in Asian Men.J Clin Aesthet Dermatol | Other paper | 2018 |
| GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.Wound Repair Regen | Other paper | 2017 |
| Selected Biomarkers Revealed Potential Skin Toxicity Caused by Certain Copper Compounds.Sci Rep | Other paper | 2016 |
| Physicochemical characterization of native glycyl-l-histidyl-l-lysine tripeptide for wound healing and anti-aging: a preformulation study for dermal delivery.Pharm Dev Technol | Other paper | 2016 |
| In vitro evaluation of compression-coated glycyl-L-histidyl-L-lysine-Cu(II) (GHK-Cu2+)-loaded microparticles for colonic drug delivery.Drug Dev Ind Pharm | Other paper | 2011 |
| Human skin penetration of a copper tripeptide in vitro as a function of skin layer.Inflamm Res | Other paper | 2011 |
| Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy.Inflamm Res | Other paper | 2010 |