# Epitalon epithalon · Ala-Glu-Asp-Gly · AEDG https://graded.pl/en/substances/epitalon · Checked: Not yet Preliminary version. The editors have not finished checking this card, and grades may change. A short lab-made peptide sold for longevity. Nearly all studies come from one research group in St Petersburg, in flies, mice, rats and cells in a dish. There is no study with random groups in people and no approved medicine in the EU or US. > This site is for information and education only. It does not promote or encourage the use or purchase of the substances described and is not medical advice. Many are not authorised as medicines and their safety has not been established. We sell nothing and have no ties to sellers. For health decisions, consult a doctor. ## Short answers ### Does epitalon work? A short lab-made peptide sold for longevity. Nearly all studies come from one research group in St Petersburg, in flies, mice, rats and cells in a dish. There is no study with random groups in people and no approved medicine in the EU or US. Longer life: grade D, not clear. Fruit flies lived 11% to 16% longer. In mice, one study found no change in average life span and another a 5% longer one. In rats on a normal day and night rhythm nothing changed. Every animal study we found comes from one research group. There are no studies with random groups in people, and none of life span. ### Is Epitalon legal? PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. No approved medicine. On 30 October 2026 the US health department (HHS) published a draft policy: it does not plan to act against pharmacies and doctors that make it on a prescription for a named patient, from an FDA-registered maker, until the FDA decides by rule. The draft is not binding, and comments close on 13 November 2026. ### Is epitalon banned in sport? May be banned, WADA 2026. It is not on the WADA list, but WADA also bans substances that no health authority has approved, so it may be banned. ### Is Epitalon safe? Not known. There are no studies with random groups, and we found no safety study in people. ## What studies show | | | | | |---|---|---|---| | Longer life | D | Not clear | Fruit flies lived 11% to 16% longer. In mice, one study found no change in average life span and another a 5% longer one. In rats on a normal day and night rhythm nothing changed. Every animal study we found comes from one research group. There are no studies with random groups in people, and none of life span. | ## Studies we have read - Epitalon and Epithalamin: A Narrative Review of Mechanistic, Preclinical, and Clinical Evidence. (Int J Mol Sci 2026; Review of studies) https://pubmed.ncbi.nlm.nih.gov/42884164/ - Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. (Bull Exp Biol Med 2007; In animals) https://pubmed.ncbi.nlm.nih.gov/18856211/ - Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. (Biogerontology 2003; In animals, n=108) https://pubmed.ncbi.nlm.nih.gov/14501183/ - Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. (Mech Ageing Dev 2001; In animals) https://pubmed.ncbi.nlm.nih.gov/11163623/ - Effect of epitalon on the lifespan increase in Drosophila melanogaster. (Mechanisms of ageing and development 2000; In animals) https://pubmed.ncbi.nlm.nih.gov/11087911/ ## Is it legal - PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet) - EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet) - US: No approval. No approved medicine. On 30 October 2026 the US health department (HHS) published a draft policy: it does not plan to act against pharmacies and doctors that make it on a prescription for a named patient, from an FDA-registered maker, until the FDA decides by rule. The draft is not binding, and comments close on 13 November 2026. https://www.federalregister.gov/documents/2026/10/30/2026-22192/enforcement-discretion-policy-regarding-503a-compounding-using-certain-peptide-bulk-drug-substances (Checked: Not yet) ## Doping May be banned, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html ## How much research exists - Scientific papers: 123 - Studies with random groups: 0 - Registered studies in people: 1 - These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026. --- Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/