# Cardarine

GW501516 · GW1516 · endurobol

https://graded.pl/en/substances/cardarine · Checked: Not yet

Preliminary version. The editors have not finished checking this card, and grades may change.

A substance that changes how muscle and liver use fat (GW501516). In short studies of up to 12 weeks it lowered blood fats. In rats and mice it caused tumours in several organs, and work on it as a medicine stopped. It is not a SARM, no such medicine exists, and sport bans it.

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## Short answers

### Does cardarine work?

A substance that changes how muscle and liver use fat (GW501516). In short studies of up to 12 weeks it lowered blood fats. In rats and mice it caused tumours in several organs, and work on it as a medicine stopped. It is not a SARM, no such medicine exists, and sport bans it. Fat loss: grade C, not clear. In a 2-week study with random groups of 6 people each, liver fat fell by 20%. Nobody reported body fat or weight loss: a company study of body fat in 71 people has no published results. Work on it as a medicine stopped after tumours appeared in rats and mice.

### Is Cardarine legal?

PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. The FDA drug register has no such medicine.

### Is cardarine banned in sport?

Banned in sport, WADA 2026.

### Is Cardarine safe?

Serious warning. In rats and mice given GW501516 daily for two years, tumours appeared in several organs, and work on it as a medicine stopped. In mice with a KRAS gene change, it sped up the path from early lesions to pancreatic cancer. These are animal results, and the longest human study we found lasted 12 weeks.

## What studies show

| | | | |
|---|---|---|---|
| Fat loss | C | Not clear | In a 2-week study with random groups of 6 people each, liver fat fell by 20%. Nobody reported body fat or weight loss: a company study of body fat in 71 people has no published results. Work on it as a medicine stopped after tumours appeared in rats and mice. |

## Studies we have read

- An Exploratory Study To Look At The Effect Of Two Investigational Drugs On Body Fat And Inflammation (ClinicalTrials.gov 2012; Random groups, n=71) https://clinicaltrials.gov/study/NCT00388180
- Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. (Diabetes 2008; Random groups, n=18) https://pubmed.ncbi.nlm.nih.gov/18024853/
- Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. (Arterioscler Thromb Vasc Biol 2007; Random groups, n=24) https://pubmed.ncbi.nlm.nih.gov/17110604/

## Is it legal

- PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- US: No approval. The FDA drug register has no such medicine. https://www.accessdata.fda.gov/scripts/cder/daf/ (Checked: Not yet)

## Doping

Banned in sport, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html

## How much research exists

- Scientific papers: 318
- Studies with random groups: 4
- Registered studies in people: 3
- These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

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Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/