# 5-amino-1MQ

5-amino-1-methylquinolinium · NNMT inhibitor

https://graded.pl/en/substances/5-amino-1mq · Checked: Not yet

Preliminary version. The editors have not finished checking this card, and grades may change.

A small molecule, not a peptide, that blocks a metabolism enzyme (NNMT). There are three scientific papers and no study in people.

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## Short answers

### Does 5-amino-1MQ work?

A small molecule, not a peptide, that blocks a metabolism enzyme (NNMT). There are three scientific papers and no study in people. Fat loss: grade D, not clear. Weight and fat fell in obese mice. There are three papers and no study in people.

### Is 5-amino-1MQ legal?

PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. The FDA drug register has no such medicine.

### Is 5-amino-1MQ banned in sport?

May be banned, WADA 2026. It is not on the WADA list, but WADA also bans substances that no health authority has approved, so it may be banned.

### Is 5-amino-1MQ safe?

Not known. Studied in mice. There are three papers and no study in people.

## What studies show

| | | | |
|---|---|---|---|
| Fat loss | D | Not clear | Weight and fat fell in obese mice. There are three papers and no study in people. |

## Studies we have read

- Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. (Scientific reports 2022; In animals) https://pubmed.ncbi.nlm.nih.gov/35013352/

## Is it legal

- PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- US: No approval. The FDA drug register has no such medicine. https://www.accessdata.fda.gov/scripts/cder/daf/ (Checked: Not yet)

## Doping

May be banned, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html

## How much research exists

- Scientific papers: 3
- Studies with random groups: 0
- Registered studies in people: 0
- These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

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Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/